Attentional bias toward negative stimuli has been observed in major depression disorders (MDD). Imaging studies suggest the engagement of fronto-limbic regions like amygdala, anterior cingulate cortex (ACC), and lateral prefrontal cortex, is related to negatively biased attention. However, neural correlates of attentional bias for negative stimuli in individuals with subthreshold depression (SubD), that is individuals who have clinically relevant depressive symptoms but do not fulfill the criteria for MDD, remain unclear. Here, we used functional neuroimaging and the dot-probe task to elucidate the neural substrates of negatively biased attention among individuals with SubD. Behavioral results found that individuals with SubD allocated more attention toward negative stimuli relative to neutral stimuli, which were not observed among non-depressed controls (NCs). Imaging results found greater amygdala and rostral ACC activity in attentional bias toward negative stimuli among participants with SubD compared to NCs; Additionally, participants with SubD showed reduced engagement of bilateral inferior frontal gyrus (IFG) compared with NCs in the attentional processing of negative stimuli. Together, these results suggest that alteration of fronto-limbic systems relative to controls, known to be related to negative detection and attentional control, is associated with negatively biased attention in individuals with subthreshold depression.

Imaging studies of subthreshold depression (StD) have reported structural and functional abnormalities in a variety of spatially diverse brain regions. However, there is no consensus among different studies. In the present study, we applied a multimodal meta‐analytic approach, the Activation Likelihood Estimation (ALE), to test the hypothesis that StD exhibits spatially convergent structural and functional brain abnormalities compared to healthy controls. A total of 31 articles with 25 experiments were included, collectively representing 1001 subjects with StD. We found consistent differences between StD and healthy controls mainly in the left insula across studies with various neuroimaging methods. Further exploratory analyses found structural atrophy and decreased functional activities in the right pallidum and thalamus in StD, and abnormal spontaneous activity converged to the middle frontal gyrus. Coordinate‐based meta‐analysis found spatially convergent structural and functional impairments in StD. These findings provide novel insights for understanding the neural underpinnings of subthreshold depression and enlighten the potential targets for its early screening and therapeutic interventions in the future.

Previous studies have shown that forgiveness is associated with the ability of self-control. However, whether self-control can modulate interpersonal forgiveness remains unclear. In the current study, we aimed to explore the relationship between self-control and the process of forgiveness using a behavioral measure of forgiveness during which participants distributed money between themselves and unknown others who had previously treated them fairly or unfairly in an adapted decision-making task. Seventy-two participants with low or high self-control were recruited based on their scores on the self-control scale (SCS). Results showed that participants exhibited increased anger and decreased happiness after experiencing unfair treatment. Participants with high self-control distributed more money to opponents who previously treated them unfairly compared with those with low self-control, whereas no such difference was observed to opponents who previously treated them fairly between the two groups. A significantly positive correlation was also found between the forgiveness rates and participants’ self-control scores. These findings suggest that self-control modulates interpersonal forgiveness responses. Individuals with high self-control expressed an increased prosocial response toward people who previously offended them, which is similar to the process of forgiveness.