In this paper, the facile synthesis of graphene oxide and MOF based composite material for the demanded adsorption of leading antibiotic is reported. The adsorbent showed good results for removal of norfloxacin with high adsorption capacity (1114.82 mg/g) and removal efficiency (93.61 %). In addition, Langmuir model proved most suitable with highest value of R² = 0.99929 among three applied isothermal models. The thermodynamic study showed spontaneous and exothermic (ΔH = −1.1×10⁻⁵ Kj/ mol, ΔG = −13324.33 Kj/ mol) nature of adsorption process with reusability of 88.4 % after several cycles. Moreover, statistical analysis and mechanistic study were also performed.