Stefano Negrini

Dr. Stefano Negrini

1. Department of Biomedical, Surgical and Dental Sciences, University "La Statale", Milan, Italy
+3
orcid

Research Focus & Metrics

Academic Career Length

37Years (1990-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
10 January 2018 in Scoliosis and Spinal Disorders
Verified
Journal Article
Open access
PDF file
Stefano NegriniStefano Negrini
Stefano Negrini
SDSabrina Donzelli
Sabrina Donzelli
Angelo Gabriele AulisaAngelo Gabriele Aulisa
Angelo Gabriele Aulisa
DCDariusz Czaprowski
Dariusz Czaprowski
SSSanja Schreiber
Sanja Schreiber
FZFabio Zaina
Fabio Zaina
The International Scientific Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT) produced its first guidelines in 2005 and renewed them in 2011. Recently published high-quality clinical trials on the effect of conservative treatment approaches (braces and exercises) for idiopathic scoliosis prompted us to update the last guidelines’ version. The objective was to align the guidelines with the new scientific evidence to assure faster knowledge transfer into clinical practice of conservative treatment for idiopathic scoliosis (CTIS). Physicians, researchers and allied health practitioners working in the area of CTIS were involved in the development of the 2016 guidelines. Multiple literature reviews reviewing the evidence on CTIS (assessment, bracing, physiotherapy, physiotherapeutic scoliosis-specific exercises (PSSE) and other CTIS) were conducted. Documents, recommendations and practical approach flow charts were developed using a Delphi procedure. The process was completed with the Consensus Session held during the first combined SOSORT/IRSSD Meeting held in Banff, Canada, in May 2016. The contents of the new 2016 guidelines include the following: background on idiopathic scoliosis, description of CTIS approaches for various populations with flow-charts for clinical practice, as well as literature reviews and recommendations on assessment, bracing, PSSE and other CTIS. The present guidelines include a total of 68 recommendations divided into following topics: bracing (n = 25), PSSE to prevent scoliosis progression during growth (n = 12), PSSE during brace treatment and surgical therapy (n = 6), other conservative treatments (n = 2), respiratory function and exercises (n = 3), general sport activities (n = 6); and assessment (n = 14). According to the agreed strength and level of evidence rating scale, there were 2 recommendations on bracing and 1 recommendation on PSSE that reached level of recommendation “I” and level of evidence “II”. Three recommendations reached strength of recommendation A based on the level of evidence I (2 for bracing and one for assessment); 39 recommendations reached strength of recommendation B (20 for bracing, 13 for PSSE, and 6 for assessment).The number of paper for each level of evidence for each treatment is shown in Table 8. The 2016 SOSORT guidelines were developed based on the current evidence on CTIS. Over the last 5 years, high-quality evidence has started to emerge, particularly in the areas of efficacy of bracing (one large multicentre trial) and PSSE (three single-centre randomized controlled trials). Several grade A recommendations were presented. Despite the growing high-quality evidence, the heterogeneity of the study protocols limits generalizability of the recommendations. There is a need for standardization of research methods of conservative treatment effectiveness, as recognized by SOSORT and the Scoliosis Research Society (SRS) non-operative management Committee.

20 January 2012 in Scoliosis and Spinal Disorders
Verified
Journal Article
Open access
PDF file
Stefano NegriniStefano Negrini
Stefano Negrini
Angelo Gabriele AulisaAngelo Gabriele Aulisa
Angelo Gabriele Aulisa
LALorenzo Aulisa
Lorenzo Aulisa
ACAlin B Circo
Alin B Circo
JMJean Claude De Mauroy
Jean Claude De Mauroy
FZFabio Zaina
Fabio Zaina
The International Scientific Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT), that produced its first Guidelines in 2005, felt the need to revise them and increase their scientific quality. The aim is to offer to all professionals and their patients an evidence-based updated review of the actual evidence on conservative treatment of idiopathic scoliosis (CTIS). All types of professionals (specialty physicians, and allied health professionals) engaged in CTIS have been involved together with a methodologist and a patient representative. A review of all the relevant literature and of the existing Guidelines have been performed. Documents, recommendations, and practical approach flow charts have been developed according to a Delphi procedure. A methodological and practical review has been made, and a final Consensus Session was held during the 2011 Barcelona SOSORT Meeting. The contents of the document are: methodology; generalities on idiopathic scoliosis; approach to CTIS in different patients, with practical flow-charts; literature review and recommendations on assessment, bracing, physiotherapy, Physiotherapeutic Specific Exercises (PSE) and other CTIS. Sixty-five recommendations have been given, divided in the following topics: Bracing (20 recommendations), PSE to prevent scoliosis progression during growth (8), PSE during brace treatment and surgical therapy (5), Other conservative treatments (3), Respiratory function and exercises (3), Sports activities (6), Assessment (20). No recommendations reached a Strength of Evidence level I; 2 were level II; 7 level III; and 20 level IV; through the Consensus procedure 26 reached level V and 10 level VI. The Strength of Recommendations was Grade A for 13, B for 49 and C for 3; none had grade D. These Guidelines have been a big effort of SOSORT to paint the actual situation of CTIS, starting from the evidence, and filling all the gray areas using a scientific method. According to results, it is possible to understand the lack of research in general on CTIS. SOSORT invites researchers to join, and clinicians to develop good research strategies to allow in the future to support or refute these recommendations according to new and stronger evidence.

1 January 2002 in Spine
Verified
Journal Article
Closed access
Stefano NegriniStefano Negrini
Stefano Negrini
RCRoberta Carabalona
Roberta Carabalona
A cross-sectional study was conducted. To investigate schoolchildren’s subjective perceptions of their daily backpack loads, to ascertain whether an association exists between these sensations or the load itself and back pain, and to identify the school, family, and personal factors that determine the backpack load, and that might, with a view to primary prevention, be addressed with specific interventions. Backpack carrying has been shown to constitute a considerable daily “occupational” load of the spine in schoolchildren. Although society perceives backpack carrying as a problem, the scientific community currently offers very few answers. The backpack load borne by schoolchildren exceeds, proportionally, the legal load-bearing limits set for adults, and the association with low back pain is questioned. All the backpacks of the 237 year 6 children in a school catchment area of Milan were weighed on six school days. The data were analyzed in groups according to the schools and classes involved, the single children, and the days of the week. A validated questionnaire also was administered to 115 schoolchildren (54 boys and 61 girls; average age, 11.7 years) whose anthropometric characteristics and loads carried daily were known. The associations among features of backpack carrying, subjective perceptions of the load (fatigue, feeling it to be heavy, pain) and back pain (point and life prevalence) were assessed and verified. School backpacks are felt to be heavy by 79.1% of children, to cause fatigue by 65.7%, and to cause back pain by 46.1%. Fatigue during and time spent backpack carrying, but not the backpack’s weight, are associated with back pain. The determining factors were found to be classes (e.g., range, 8.87–10.59 kg), days of the week (e.g., range, 5.75–12.74 kg.), and single students (e.g., range, 4.2–9.5 kg.), but not individual schools. Daily backpack carrying is a frequent cause of discomfort for schoolchildren. There is an association between this load and back pain, although the relationship is not direct. The results suggest the existence of personal physical and psychological factors that need to be investigated. Reduction of the daily backpack load borne by schoolchildren is recommended both on the basis of the current results and because it exceeds, proportionally, the legal load limits set for adults. All the different parties involved (school system, parents, children) play a role, and if the aim is to reduce this “weight of culture,” all should be targeted through specific interventions. Recommendations are supplied for the achievement of this aim.

10 April 2006 in Scoliosis and Spinal Disorders
Verified
Journal Article
Open access
PDF file
Stefano NegriniStefano Negrini
Stefano Negrini
Theodoros GrivasTheodoros Grivas
Theodoros Grivas
TKTomasz Kotwicki
Tomasz Kotwicki
TMToru Maruyama
Toru Maruyama
MRManuel Rigo
Manuel Rigo
T(the members of the Scientific society On Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT)
the members of the Scientific society On Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT)
Background: Medicine is a scientific art: once science is not clear, choices are made according to individual and collective beliefs that should be better understood. This is particularly true in a field like adolescent idiopathic scoliosis, where currently does not exist definitive scientific evidence on the efficacy either of conservative or of surgical treatments.Aim of the study: To verify the philosophical choices on the final outcome of a group of people believing and engaged in a conservative treatment of idiopathic scoliosis.Methods: We performed a multifaceted study that included a bibliometric analysis, a questionnaire, and a careful Consensus reaching procedure between experts in the conservative treatment of scoliosis (SOSORT members).Results: The Consensus reaching procedure has shown to be useful: answers changed in a statistically significant way, and 9 new outcome criteria were included. The most important final outcomes were considered Aesthetics (100%), Quality of life and Disability (more than 90%), while more than 80% of preferences went to Back Pain, Psychological well-being, Progression in adulthood, Breathing function, Scoliosis Cobb degrees (radiographic lateral flexion), Needs of further treatments in adulthood.Discussion: In the literature prevail outcome criteria driven by the contingent treatment needs or the possibility to have measurement systems (even if it seems that usual clinical and radiographic methods are given much more importance than more complex Disability or Quality of Life instruments). SOSORT members give importance to a wide range of outcome criteria, in which clinical and radiographic issues have the lowest importance.Conclusion: We treat our patients for what they need for their future (Breathing function, Needs of further treatments in adulthood, Progression in adulthood), and their present too (Aesthetics, Disability, Quality of life). Technical matters, such as rib hump or radiographic lateral alignment and rotation, but not lateral flexion, are secondary outcomes and only instrumental to previously reported primary outcomes. We advocate a multidimensional, comprehensive evaluation of scoliosis patients, to gather all necessary data for a complete therapeutic approach, that goes beyond x-rays to reach the person and the family.

7 March 2015 in Scoliosis
Verified
Journal Article
Open access
PDF file
SBSosort Boards
Sosort Boards
Stefano NegriniStefano Negrini
Stefano Negrini
Theodoros GrivasTheodoros Grivas
Theodoros Grivas
MHM. Timothy Hresko
M. Timothy Hresko
JOJoseph P O’brien
Joseph P O’brien
NPNigel Price
Nigel Price
The two main societies clinically dealing with idiopathic scoliosis are the Scoliosis Research Society (SRS), founded in 1966, and the international Society on Scoliosis Orthopedic and Rehabilitation Treatment (SOSORT), started in 2004. Inside the SRS, the Non-Operative Management Committee (SRS-NOC) has the same clinical interest of SOSORT, that is the Orthopaedic and Rehabilitation (or Non-Operative, or conservative) Management of idiopathic scoliosis patients. The aim of this paper is to present the results of a Consensus among the best experts of non-operative treatment of Idiopathic Scoliosis, as represented by SOSORT and SRS, on the recommendation for research studies on treatment of Idiopathic Scoliosis. The goal of the consensus statement is to establish a framework for research with clearly delineated inclusion criteria, methodologies, and outcome measures so that future meta- analysis or comparative studies could occur. A Delphi method was used to generate a consensus to develop a set of recommendations for clinical studies on treatment of Idiopathic Scoliosis. It included the development of a reference scheme, which was judged during two Delphi Rounds; after this first phase, it was decided to develop the recommendations and 4 other Delphi Rounds followed. The process finished with a Consensus Meeting, that was held during the SOSORT Meeting in Wiesbaden, 8–10 May 2014, moderated by the Presidents of SOSORT (JP O’Brien) and SRS (SD Glassman) and by the Chairs of the involved Committees (SOSORT Consensus Committee: S Negrini; SRS Non-Operative Committee: MT Hresko). The Boards of the SRS and SOSORT formally accepted the final recommendations. The 18 Recommendations focused: Research needs (3), Clinically significant outcomes (4), Radiographic outcomes (3), Other key outcomes (Quality of Life, adherence to treatment) (2), Standardization of methods of non-operative research (6).

8 May 2006 in Scoliosis and Spinal Disorders
Verified
Journal Article
Open access
PDF file
SCSOSORT guideline committee
SOSORT guideline committee
HWHans-Rudolf Weiss
Hans-Rudolf Weiss
Stefano NegriniStefano Negrini
Stefano Negrini
MRManuel Rigo
Manuel Rigo
TKTomasz Kotwicki
Tomasz Kotwicki
FLFranz Landauer
Franz Landauer
This guideline has been discussed by the SOSORT guideline committee prior to the SOSORT consensus meeting in Milan, January 2005 and published in its first version on the SOSORT homepage: http://www.sosort.org/meetings.php. After the meeting it again has been discussed by the members of the SOSORT guideline committee to establish the final 2005 version submitted to Scoliosis, the official Journal of the society, in December 2005.