Recently, graphene-based nanomaterials, in the form of two dimensional substrates or three dimensional foams, have attracted considerable attention as bioactive scaffolds to promote the differentiation of various stem cells towards specific lineages. On the other hand, the potential advantages of using graphene-based hybrid composites directly as factors inducing cellular differentiation as well as tissue regeneration are unclear. This study examined whether nanocomposites of reduced graphene oxide (rGO) and hydroxyapatite (HAp) (rGO/HAp NCs) could enhance the osteogenesis of MC3T3-E1 preosteoblasts and promote new bone formation. When combined with HAp, rGO synergistically promoted the spontaneous osteodifferentiation of MC3T3-E1 cells without hindering their proliferation. This enhanced osteogenesis was corroborated from determination of alkaline phosphatase activity as early stage markers of osteodifferentiation and mineralization of calcium and phosphate as late stage markers. Immunoblot analysis showed that rGO/HAp NCs increase the expression levels of osteopontin and osteocalcin significantly. Furthermore, rGO/HAp grafts were found to significantly enhance new bone formation in full-thickness calvarial defects without inflammatory responses. These results suggest that rGO/HAp NCs can be exploited to craft a range of strategies for the development of novel dental and orthopedic bone grafts to accelerate bone regeneration because these graphene-based composite materials have potentials to stimulate osteogenesis.

Structurally stabilized Na₃V₂(PO₄)₃/C composite cathode materials with excellent electrochemical performance can be obtained by incorporating functional pillar ions into the structure. As pillar ions, K-ions have a larger ionic radius compared to Na-ions, and play an important role in enlarging the Na-ion diffusion pathway and in increasing the lattice volume by elongating the c-axis, thereby improving the rate performance. Furthermore, since the incorporated K-ions rarely participate in the electrochemical extraction/insertion reactions, they can stabilize the Na₃V₂(PO₄)₃ structure by suppressing significant lattice volume changes or structural distortion, even in a wide range of voltage windows accompanying multiple transitions of V ions and phase distortions. We investigated how the K-ion doping level affected the crystal structure and electrochemical properties of Na₃V₂(PO₄)₃ cathode materials for Na-ion batteries.

As lithium-ion batteries have been the state-of-the-art electrochemical energy storage technology, the overwhelming demand for energy storage on a larger scale has triggered the development of next-generation battery technologies possessing high energy density, longer cycle lives, and enhanced safety. However, commercial liquid electrolytes have been plagued by safety issues due to their flammability and instability in contact with electrodes. Efforts have focused on developing such electrolytes by covalently immobilizing anionic groups onto a polymer backbone, which only allows Li⁺ cations to be mobile through the polymer matrix. Such ion-selective polymers provide many advantages over binary ionic conductors in battery operation, such as minimization of cell polarization and dendrite growth. In this review, the design, synthesis, fabrication, and class are reviewed to give insight into the physicochemical properties of single-ion conducting polymer electrolytes. The standard characterization method and remarkable electrochemical properties are further highlighted, and perspectives on current challenges and future directions are also discussed.