Dr. H. Douglas Morris
Radiology and Bioengineering, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Academic Career Length
38Years (1989-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 April 2003 in Neuroscience
Journal Article
RSRodney Swain
Rodney SwainAHA.B Harris
A.B Harris
EWE.C Wiener
E.C Wiener
MDM.V Dutka
M.V Dutka
H. Douglas MorrisWGW.T Greenough
W.T Greenough
+4
20 April 2011 in Lab Animal
Journal Article
TYTal Yardeni
Tal Yardeni
MEMichael Eckhaus
Michael Eckhaus
H. Douglas MorrisMHMarjan Huizing
Marjan Huizing
SHShelley Hoogstraten-Miller
Shelley Hoogstraten-Miller30 September 2015 in Science Translational Medicine
Journal Article
WLWenxue Li
Wenxue Li
MLMyoung-Hwa Lee
Myoung-Hwa Lee
LHLisa Henderson
Lisa Henderson
RTRicha Tyagi
Richa Tyagi
MBMuzna Bachani
Muzna Bachani
ANAvindra Nath
Avindra Nath +12
The role of human endogenous retroviruses (HERVs) in disease pathogenesis is unclear. We show that HERV-K is activated in a subpopulation of patients with sporadic amyotrophic lateral sclerosis (ALS) and that its envelope (env) protein may contribute to neurodegeneration. The virus was expressed in cortical and spinal neurons of ALS patients, but not in neurons from control healthy individuals. Expression of HERV-K or its env protein in human neurons caused retraction and beading of neurites. Transgenic animals expressing the env gene developed progressive motor dysfunction accompanied by selective loss of volume of the motor cortex, decreased synaptic activity in pyramidal neurons, dendritic spine abnormalities, nucleolar dysfunction, and DNA damage. Injury to anterior horn cells in the spinal cord was manifested by muscle atrophy and pathological changes consistent with nerve fiber denervation and reinnervation. Expression of HERV-K was regulated by TAR (trans-activation responsive) DNA binding protein 43, which binds to the long terminal repeat region of the virus. Thus, HERV-K expression within neurons of patients with ALS may contribute to neurodegeneration and disease pathogenesis.
15 February 2016 in Journal of Experimental Medicine
Journal Article
VPVladislav Pokatayev
Vladislav Pokatayev
NHNaushaba Hasin
Naushaba Hasin
HCHyongi Chon
Hyongi Chon
SCSusana M. Cerritelli
Susana M. Cerritelli
KSKiran Sakhuja
Kiran Sakhuja
RCRobert Crouch
Robert Crouch +3
The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops from mutations in genes encoding several nucleotide-processing proteins, including RNase H2. Defective RNase H2 may induce accumulation of self-nucleic acid species that trigger chronic type I interferon and inflammatory responses, leading to AGS pathology. We created a knock-in mouse model with an RNase H2 AGS mutation in a highly conserved residue of the catalytic subunit, Rnaseh2aG37S/G37S (G37S), to understand disease pathology. G37S homozygotes are perinatal lethal, in contrast to the early embryonic lethality previously reported for Rnaseh2b- or Rnaseh2c-null mice. Importantly, we found that the G37S mutation led to increased expression of interferon-stimulated genes dependent on the cGAS–STING signaling pathway. Ablation of STING in the G37S mice results in partial rescue of the perinatal lethality, with viable mice exhibiting white spotting on their ventral surface. We believe that the G37S knock-in mouse provides an excellent animal model for studying RNASEH2-associated autoimmune diseases.
1 December 2017 in Biological Psychiatry
Journal Article
TSTimothy J. Schoenfeld
Timothy J. SchoenfeldHMHayley C. McCausland
Hayley C. McCausland
H. Douglas MorrisVPVarun Padmanaban
Varun Padmanaban
HCHeather A. Cameron
Heather A. Cameron
16 November 2010 in Magnetic Resonance in Medicine
Journal Article
SDSam E. Day
Sam E. Day
MKMikko I. Kettunen
Mikko I. KettunenMCMurali Krishna Cherukuri
Murali Krishna Cherukuri
JMJames B. Mitchell
James B. Mitchell
MLMartin J. Lizak
Martin J. Lizak
KBKevin Brindle
Kevin Brindle +3
We show here that hyperpolarized [1‐13C]pyruvate can be used to detect treatment response in a glioma tumor model; a tumor type where detection of response with 18fluoro‐2‐deoxyglucose, using positron emission tomography, is limited by the high background signals from normal brain tissue. 13C chemical shift images acquired following intravenous injection of hyperpolarized [1‐13C]pyruvate into rats with implanted C6 gliomas showed significant labeling of lactate within the tumors but comparatively low levels in surrounding brain.Labeled pyruvate was observed at high levels in blood vessels above the brain and from other major vessels elsewhere but was detected at only low levels in tumor and brain.The ratio of hyperpolarized 13C label in tumor lactate compared to the maximum pyruvate signal in the blood vessels was decreased from 0.38 ± 0.16 to 0.23 ± 0.13, (a reduction of 34%) by 72 h following whole brain irradiation with 15 Gy. Magn Reson Med, 2011.
About Me
My work focuses on magnetic resonance imaging of changes in anatomy and physiology with application to the brain and other markers in neuroarchitecture. As a physicist, chemist, and engineer I use these tools in devising new MRI methods to reveal changes in the microscopic structure of the brain and correlate with functional and psychological effects on the mind and emotions.
Disciplines
Neuroradiology - Medical Technology - Radiology - Biomedical Engineering - Biosystems Engineering - Instrumentation - Engineering - Spectroscopy - Medicinal Chemistry -Nanotechnology
Skills and expertise
Medical Imaging - Micro-CT - NMR Spectroscopy - Medical Technology - Medical Imaging Physics - Magnetic Resonance Imaging - MRI Engineering - Remote Instrument control -Image Reconstruction - Solid State NMR - RF Engineering - Image Analysis - Computed Tomography - Image Segmentation - Biomedical Engineering - Signal Processing Hyperpolarized NMR - Diffusion Magnetic Resonance Imaging - RF Electronics - Hyperpolarized 13C MRI - MRI Receiver Design - Contrast Agents - RF Coil Design - Pulse Sequence Programming - Facility Design and Construction - Imaging - MRS - Medical and Biomedical Image Processing - Biomedical Imaging - Medical Image Analysis - Magnetic Resonance - Small Animal Imaging
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