Objectives: Multiple clinical trials have been conducted to investigate the therapeutic effects of blinatumomab on acute lymphoblastic leukemia (ALL) and non-Hodgkin’s lymphoma (NHL). We did a meta-analysis including 8 clinical trials to verify the efficacy and safety of blinatumomab in patients with relapsed/refractory ALL and NHL. Methods: We searched and investigated all relevant publications from PubMed, Web of Science, Embase, and ClinicalTrials.gov. The primary endpoint was complete remission (CR). The secondary end points were the minimal residual disease (MRD) response, and the adverse effects including cytokine release syndrome (CRS) and grade ≥ 3 neurological events. Results: Our study showed that the pooled CR rate was 0.45 (95% CI: 0.37–0.53) in ALL and 0.20 (0.12–0.27) in NHL respectively. The pooled CR rate is higher in ALL patients with BM blasts <50% than that of patients with BM blasts ≥50% (0.75 versus 0.33). A history of allo-HSCT has no effect on the CR rate. The pooled MRD response rate was 0.42 (95% CI: 0.29–0.54) in ALL. For adverse effects, the pooled occurrence rate of grade ≥3 CRS was 0.04 (95% CI: 0.01–0.06), and the pooled occurrence rate of grade ≥ 3 neurological events was 0.12 (95% CI: 0.08–0.16). Discussion: Blinatumomab is effective in treating relapsed/refractory ALL and NHL. ALL patients manifested better therapeutic response than NHL patients and a reduced tumor load favored the clinical response. For adverse effects, severe CRS and neurological events did not happen very often. Conclusion: Blinatumomab shows valid therapeutic effects and limited adverse response in treating relapsed/refractory ALL and NHL in our meta-analysis

Myelodysplastic syndromes (MDS) are clonal hematopoietic neoplasms characterized by chronic cytopenias and abnormal cell morphology, with a propensity to progress to bone marrow failure or acute myeloid leukemia. Behcet’s syndrome is a systemic vasculitis distinguished by recurrent oral ulcers, skin lesions, and ocular inflammation. In recent years, an increasing number of clinical cases have reported the coexistence of MDS and Behcet’s syndrome, suggesting a potential pathological relationship between these conditions. Abnormal immune cell activation, dysregulated cytokine secretion, and cytogenetic alterations are thought to play critical roles in the pathogenesis of MDS combined with Behcet’s syndrome. Currently, treatment strategies for MDS combined with Behcet’s syndrome are primarily individualized and include immunosuppressive therapy, cytotoxic drug therapy, and targeted therapy. However, due to the limited number of case reports and insufficient research on the underlying mechanisms, selecting appropriate treatment options remains challenging. This article reviews the pathogenesis and interrelationships of MDS combined with Behcet’s syndrome and summarizes recent advancements in treatment strategies, providing a reference for clinical diagnosis and management.