Dr. Yana Gocheva
The Stephan Angeloff Institute of Microbiology, Bulgarian Ac...
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Academic Career Length
26Years (2001-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications17 December 2008 in Extremophiles
Journal Article
Yana GochevaSTSolveig Tosi
Solveig TosiEKEkaterina Tz. Krumova
Ekaterina Tz. Krumova
LSLyudmila S. Slokoska
Lyudmila S. Slokoska
JMJeny G. Miteva
Jeny G. Miteva
MAMaria Angelova
Maria Angelova +1
1 November 2006 in Mycological Research
Journal Article
Yana GochevaEKEkaterina Tz. Krumova
Ekaterina Tz. Krumova
LSLyudmila S. Slokoska
Lyudmila S. Slokoska
JMJeny G. Miteva
Jeny G. Miteva
SVSpassen V. Vassilev
Spassen V. Vassilev
MAMaria B. Angelova
Maria B. Angelova
1 June 2006 in Biosensors and Bioelectronics
Journal Article
BBBogdan Bucur
Bogdan BucurEMElena Mallat
Elena Mallat
AGAna-Maria Gurban
Ana-Maria GurbanYana GochevaCVCarine Velasco
Carine Velasco
TNThierry Noguer
Thierry Noguer
+1
Journal Article
LYLuydmila Yovchevska
Luydmila YovchevskaYana GochevaGSGalina Dinkova Stoyancheva
Galina Dinkova StoyanchevaJMJeny Miteva-Staleva
Jeny Miteva-StalevaVDVladislava Dishliyska
Vladislava DishliyskaEKEkaterina Tz Krumova
Ekaterina Tz Krumova +3
Extremophiles are of significant scientific interest due to their unique adaptation to harsh environmental conditions and their potential for diverse biotechnological applications. Among these extremophiles, filamentous fungi adapted to high-salt environments represent a new and valuable source of enzymes, biomolecules, and biomaterials. While most studies on halophiles have focused on bacteria, reports on filamentous fungi remain limited. This review compiles information about salt-adapted fungi and details their distribution, adaptation mechanisms, and potential applications in various societal areas. Understanding the adaptive mechanisms of halophilic fungi not only sheds light on the biology of extremophilic fungi but also leads to promising biotechnological applications, including the development of salt-tolerant enzymes and strategies for bioremediation of saline habitats. To fully realize this potential, a comprehensive understanding of their ecology, diversity and physiology is crucial. In addition, understanding their survival mechanisms in saline environments is important for the development of astrobiology. The significant potential of applications of halophilic fungi is highlighted.
4 March 2010 in Cellular and Molecular Life Sciences
Journal Article
OVOlga Voloshin
Olga Voloshin
Yana GochevaMGMarina Gutnick
Marina Gutnick
NMNatalia Movshovich
Natalia Movshovich
ABAnya Bakhrat
Anya Bakhrat
DRDina Raveh
Dina Raveh +4
Mutation of tubulin chaperone E (TBCE) underlies hypoparathyroidism, retardation, and dysmorphism (HRD) syndrome with defective microtubule (MT) cytoskeleton. TBCE/yeast Pac2 comprises CAP-Gly, LRR (leucine-rich region), and UbL (ubiquitin-like) domains. TBCE folds α-tubulin and promotes α/β dimerization. We show that Pac2 functions in MT dynamics: the CAP-Gly domain binds α-tubulin and MTs, and functions in suppression of benomyl sensitivity of pac2Δ mutants. Pac2 binds proteasomes: the LRR binds Rpn1, and the UbL binds Rpn10; the latter interaction mediates Pac2 turnover. The UbL also binds the Skp1-Cdc53-F-box (SCF) ubiquitin ligase complex; these competing interactions for the UbL may impact on MT dynamics. pac2Δ mutants are sensitive to misfolded protein stress. This is suppressed by ectopic PAC2 with both the CAP-Gly and UbL domains being essential. We propose a novel role for Pac2 in the misfolded protein stress response based on its ability to interact with both the MT cytoskeleton and the proteasomes.
Journal Article
ECElena Chorukova
Elena ChorukovaVHVenelin Hubenov
Venelin HubenovYana GochevaISIvan Simeonov Simeonov
Ivan Simeonov SimeonovExperimental studies of two-phase anaerobic digestion of corn steep liquor in semi-continuous automatic and semi-automatic modes of operation of a cascade of two anaerobic bioreactors with monitoring and control systems were performed. Corn steep liquor—a waste product from the process of treating corn grain for starch extraction—was used as a substrate in the process of anaerobic digestion with simultaneous hydrogen and methane production. The daily yields of biohydrogen in bioreactor 1 of the cascade (with a working volume of 8 dm3) are variable. In good operation, they are in the range of 0.7 to 1.0 L of biogas from a 1 dm3 working volume of the bioreactor, and the optimal pH is in the range of 5.0–5.5. The concentration of hydrogen in the biogas from the hydrogen bioreactor 1 is in the range of 14–34.7%. The daily yields of biomethane in bioreactor 2 of the cascade (with a working volume of 80 dm3) vary in the range 0.4 to 0.85 L of biogas from a 1 dm3 working volume of the bioreactor, and the concentration of methane in the biogas from bioreactor 2 is high and remains practically constant (in the range 65–69%). At a dilution rate of 0.4 day−1 and an organic loading rate of 20 gL for bioreactor 1, respectively, and a dilution rate of 0.05 day−1 for bioreactor 2, the best results were obtained. The computer control system is presented. Some energetical considerations were discussed.
About Me
Dr. Yana Gocheva is an Associate Professor at the Department of General Microbiology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences. She holds an MSc in Biotechnology and a PhD in Microbiology from Sofia University “St. Kliment Ohridsky”, and an MSc in Economics with specialization in International Project Management from the University of National and World Economy, Sofia.
Her academic background is complemented by postdoctoral research at Ben-Gurion University of the Negev (Israel) and GTP Technology (France).
Dr. Gocheva has research expertise in microbial biochemistry and biotechnology, with a focus on the production, purification, and characterization of microbial enzymes, including sialidases and phytases. She also studies bioactive components with antimicrobial activity, and microbial biodegradation of lignocellulosic waste. Dr. Gocheva has authored 41 peer-reviewed publications, 30 of which are in journals with impact factor, and her work has received over 200 citations indexed in Scopus.
She has actively participated in and contributed to multiple research projects funded by the Bulgarian National Science Fund, addressing innovative topics such as novel microbial enzymes, biofuels, antimicrobial and photocatalytic materials, and microbial biodegradation under terrestrial and spaceflight-related conditions. Society. Keywords: Batreria; Fungi; Microbial enzymes; Sialidases; Phytases; Microbial biotechnology; Antimicrobial activity.
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