Hugh Byrne

Prof. Hugh Byrne

Technological University Dublin
orcid

Research Focus & Metrics

Academic Career Length

42Years (1985-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2007 in Toxicology in Vitro
Verified
Journal Article
Closed access
MDMaria Davoren
Maria Davoren
EHEva Herzog
Eva Herzog
ACAlan Casey
Alan Casey
BCBenjamin Cottineau
Benjamin Cottineau
GCGordon Chambers
Gordon Chambers
Fiona LyngFiona Lyng
Fiona Lyng

15 December 2009 in The Analyst
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Journal Article
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PDF file
PBPaul Bassan
Paul Bassan
AKAchim Kohler
Achim Kohler
HMHarald Martens
Harald Martens
JLJoe Lee
Joe Lee
Hugh ByrneHugh Byrne
Hugh Byrne
PGPeter Gardner
Peter Gardner
Infrared spectra of single biological cells often exhibit the ‘dispersion artefact’ observed as a sharp decrease in intensity on the high wavenumber side of absorption bands, in particular the Amide I band at ∼1655 cm−1, causing a downward shift of the true peak position. The presence of this effect makes any biochemical interpretation of the spectra unreliable. Recent theory has shed light on the origins of the ‘dispersion artefact’ which has been attributed to resonant Mie scattering (RMieS). In this paper a preliminary algorithm for correcting RMieS is presented and evaluated using simulated data. Results show that the ‘dispersion artefact’ appears to be removed; however, the correction is not perfect. An iterative approach was subsequently implemented whereby the reference spectrum is improved after each iteration, resulting in a more accurate correction. Consequently the corrected spectra become increasingly more representative of the pure absorbance spectra. Using this correction method reliable peak positions can be obtained.

7 October 2014 in Analytical Methods
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Journal Article
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Furong TianFurong Tian
Furong Tian
FBFranck Bonnier
Franck Bonnier
ACAlan Casey
Alan Casey
ASAnne E. Shanahan
Anne E. Shanahan
Hugh ByrneHugh Byrne
Hugh Byrne
The dependence of the Surface Enhanced Raman Scattering (SERS) by gold nanoparticles on their shape is examined using the organic dye, rhodamine 6G (R6G) as probe molecule.

11 June 2009 in The Analyst
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Journal Article
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PDF file
PBPaul Bassan
Paul Bassan
Hugh ByrneHugh Byrne
Hugh Byrne
FBFranck Bonnier
Franck Bonnier
JLJoe Lee
Joe Lee
PDPaul Dumas
Paul Dumas
PGPeter Gardner
Peter Gardner
Infrared spectroscopic cytology is potentially a powerful clinical tool. However, in order for it to be successful, practitioners must be able to extract reliably a pure absorption spectrum from a measured spectrum that often contains many confounding factors. The most intractable problem to date is the, so called, dispersion artefact which most prominently manifests itself as a sharp decrease in absorbance on the high wavenumber side of the amide I band in the measured spectrum, exhibiting a derivative-like line shape. In this paper we use synchrotron radiation FTIR micro-spectroscopy to record spectra of mono-dispersed poly(methyl methacrylate) (PMMA) spheres of systematically varying size and demonstrate that the spectral distortions in the data can be understood in terms of resonant Mie scattering. A full understanding of this effect will enable us to develop strategies for deconvolving the scattering contribution and recovering the pure absorption spectrum, thus removing one of the last technological barriers to the development of clinical spectroscopic cytology.

1 June 2007 in Carbon
Verified
Journal Article
Closed access
ACA. Casey
A. Casey
EHE. Herzog
E. Herzog
MDM. Davoren
M. Davoren
Fiona LyngFiona Lyng
Fiona Lyng
Hugh ByrneHugh Byrne
Hugh Byrne
GCG. Chambers
G. Chambers

1 November 1985 in Optics Communications
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Journal Article
Closed access
Werner BlauWerner Blau
Werner Blau
Hugh ByrneHugh Byrne
Hugh Byrne
WDW.M. Dennis
W.M. Dennis
JKJ.M. Kelly
J.M. Kelly