As examples of “Click Chemistry”, the reaction of 1-(oxiran-2-ylmethyl)piperidine with several 1,2,4-triazoles derivatives was studied. As a result, the reaction shows that the oxirane ring opens regiospecifically, according to Krasusky’s rule, without using a catalyst. The basic nitrogen present in 1-(oxiran-2-ylmethyl)piperidine has a catalytic (anchimer) effect.

As examples of “Click Chemistry”, the reaction of 1-(oxiran-2-ylmethyl)piperidine with several 1,2,4-triazoles derivatives was studied. According to as a result, the reaction shows that the oxirane ring opens regiospecifically, according to Krasusky’s rule, without using a catalyst. The basic nitrogen present in 1-(oxiran-2-ylmethyl)piperidine has a catalytic (anchimer) effect.

(Z)-4-Arylidenehexahydro-2H-pyrido[1,2-a]pyrazin-3(4H)-ones were synthesized starting from (Z)-4-arylidene-2-phenyl-1,3-oxazol-5(4H)-ones and piperidin-2- ylmethanamine, and optimal conditions for their synthesis were found. It was found that (Z)-arylidenehexahydro-2H-pyrido[1,2-a]pyrazin-3-(4H)-ones undergo cleavage in an acidic medium to form 2-piperidylmethylamides of 2-oxopropionic acids. UV spectra, mass-spectra and anticholinesterase properties of the synthesized compounds were studied.