The Cape Genet (Genetta tigrina) is one of the exotic mammal species that are becoming popular as pets. Although it is possible to find some references in the literature regarding Genetta spp. and viverrids, the information about this animal remains scarce and incomplete, starting from the anatomy, a discipline that lays the foundations for deeper knowledge of a species. The aim of the present study is to identify head structures of the Cape Genet, including the skull, brain components, and the dental formula, providing for the first time a three-dimensional anatomical model of the skull, thanks to the help of advanced diagnostic imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI), defining the ideal parameters and protocols of CT, MRI, and anesthesia for this procedure in this species. Results highlight the value of CT and MRI as study tools, enabling clear visualization of cranial structures and offering a potential reference atlas for clinicians and researchers.