Natasha D. Sheybani

Prof. Natasha D. Sheybani

orcid

Research Focus & Metrics

Academic Career Length

9Years (2018-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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10 March 2022 in Journal of Neuro-Oncology
Verified
Journal Article
Open access
PDF file
JRJill W. Roberts
Jill W. Roberts
LHLauren Hadley
Lauren Hadley
Natasha D. SheybaniNatasha D. Sheybani
Natasha D. Sheybani
SLSuzanne LeBlang
Suzanne LeBlang
Purpose: Six years ago, in 2015, the Focused Ultrasound Foundation sponsored a workshop to discuss, and subsequently transition the landscape, of focused ultrasound as a new therapy for treating glioblastoma. Methods: This year, in 2021, a second workshop was held to review progress made in the field. Discussion topics included blood–brain barrier opening, thermal and nonthermal tumor ablation, immunotherapy, sonodynamic therapy, and desired focused ultrasound device improvements. Results: The outcome of the 2021 workshop was the creation of a new roadmap to address knowledge gaps and reduce the time it takes for focused ultrasound to become part of the treatment armamentarium and reach clinical adoption for the treatment of patients with glioblastoma. Priority projects identified in the roadmap include determining a well-defined algorithm to confirm and quantify drug delivery following blood–brain barrier opening, identifying a focused ultrasound-specific microbubble, exploring the role of focused ultrasound for liquid biopsy in glioblastoma, and making device modifications that better support clinical needs. Conclusion: This article reviews the key preclinical and clinical updates from the workshop, outlines next steps to research, and provides relevant references for focused ultrasound in the treatment of glioblastoma.

1 January 2020 in Theranostics
Verified
Journal Article
Open access
Natasha D. SheybaniNatasha D. Sheybani
Natasha D. Sheybani
ABAlec J. Batts
Alec J. Batts
AMAlexander S. Mathew
Alexander S. Mathew
ETE. Andrew Thim
E. Andrew Thim
RPRichard J. Price
Richard J. Price
Background: Increasing evidence points to the critical role of extracellular vesicles (EVs) as molecular parcels that carry a diverse array of bioactive payloads for coordination of complex intracellular signaling. Focused ultrasound (FUS) hyperthermia is a technique for non-invasive, non-ionizing sublethal heating of cells in a near-instantaneous manner; while it has been shown to improve drug delivery and immunological recognition of tumors, its impact on EVs has not been explored to date. The goal of this study was to determine whether FUS impacts the release, proteomic profile, and immune-activating properties of tumor-derived EVs.

18 January 2021 in Journal of Controlled Release
Verified
Journal Article
Closed access
Natasha D. SheybaniNatasha D. Sheybani
Natasha D. Sheybani
VBVictoria R. Breza
Victoria R. Breza
SPSoumen Paul
Soumen Paul
KMKatelyenn S. McCauley
Katelyenn S. McCauley
SBStuart S. Berr
Stuart S. Berr
RPRichard J Price
Richard J Price

1 January 2020 in Theranostics
Verified
Journal Article
Open access
CCColleen T. Curley
Colleen T. Curley
ASAaron D. Stevens
Aaron D. Stevens
AMAlexander S. Mathew
Alexander S. Mathew
KSKatarzyna Stasiak
Katarzyna Stasiak
WGWilliam J. Garrison
William J. Garrison
RPRichard J Price
Richard J Price
Background: Focused ultrasound (FUS) activation of microbubbles (MBs) for blood-brain (BBB) and blood-tumor barrier (BTB) opening permits targeted therapeutic delivery. While the effects of FUS+MBs mediated BBB opening have been investigated for normal brain tissue, no such studies exist for intracranial tumors. As this technology advances into clinical immunotherapy trials, it will be crucial to understand how FUS+MBs modulates the tumor immune microenvironment.

3 November 2021 in Journal of Neuro-Oncology
Verified
Journal Article
Closed access
PDF file
Natasha D. SheybaniNatasha D. Sheybani
Natasha D. Sheybani
AWAlexandra R. Witter
Alexandra R. Witter
WGWilliam J. Garrison
William J. Garrison
GMG. Wilson Miller
G. Wilson Miller
RPRichard J Price
Richard J Price
TBTimothy N Bullock
Timothy N Bullock

1 May 2022 in Radiology: Artificial Intelligence
Verified
Journal Article
Closed access
RYRikiya Yamashita
Rikiya Yamashita
TKTara Kapoor
Tara Kapoor
MAMinhaj Alam
Minhaj Alam
AGAlfiia Galimzianova
Alfiia Galimzianova
SSSaad Ali Syed
Saad Ali Syed
TDTerry S. Desser
Terry S. Desser
A risk stratification system for thyroid nodules was developed to leverage US cine images and reduce false-positive biopsies by revising the American College of Radiology Thyroid Imaging Reporting ... Purpose To develop a deep learning–based risk stratification system for thyroid nodules using US cine images. Materials and Methods In this retrospective study, 192 biopsy-confirmed thyroid nodules...