Clive Prestidge

Prof. Clive Prestidge

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia
orcid

Research Focus & Metrics

Academic Career Length

27Years (2000-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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6 September 2018 in Nature Nanotechnology
Verified
Journal Article
Open access
PDF file
MFMatthew Faria
Matthew Faria
MBMattias Björnmalm
Mattias Björnmalm
KTKristofer J. Thurecht
Kristofer J. Thurecht
SKStephen J. Kent
Stephen J. Kent
RPRobert G. Parton
Robert G. Parton
FCFrank Caruso
Frank Caruso
Studying the interactions between nanoengineered materials and biological systems plays a vital role in the development of biological applications of nanotechnology and the improvement of our fundamental understanding of the bio–nano interface. A significant barrier to progress in this multidisciplinary area is the variability of published literature with regards to characterizations performed and experimental details reported. Here, we suggest a ‘minimum information standard’ for experimental literature investigating bio–nano interactions. This standard consists of specific components to be reported, divided into three categories: material characterization, biological characterization and details of experimental protocols. Our intention is for these proposed standards to improve reproducibility, increase quantitative comparisons of bio–nano materials, and facilitate meta analyses and in silico modelling.

6 September 2024 in Nature Nanotechnology
Verified
Journal Article
Closed access
PDF file
Joyce PaulJoyce Paul
Joyce Paul
CAChristine J. Allen
Christine J. Allen
MAMaria Jose Alonso
Maria Jose Alonso
MAMarianne Ashford
Marianne Ashford
MBMichelle S. Bradbury
Michelle S. Bradbury
Hélder SantosHélder Santos
Hélder Santos

10 November 2015 in Nature Communications
Verified
Journal Article
Open access
PDF file
BDBahman Delalat
Bahman Delalat
VSVonda C. Sheppard
Vonda C. Sheppard
SGSoraya Rasi Ghaemi
Soraya Rasi Ghaemi
SRShasha Rao
Shasha Rao
Clive PrestidgeClive Prestidge
Clive Prestidge
NVNicolas Voelcker
Nicolas Voelcker
The ability to selectively kill cancerous cell populations while leaving healthy cells unaffected is a key goal in anticancer therapeutics. The use of nanoporous silica-based materials as drug-delivery vehicles has recently proven successful, yet production of these materials requires costly and toxic chemicals. Here we use diatom microalgae-derived nanoporous biosilica to deliver chemotherapeutic drugs to cancer cells. The diatom Thalassiosira pseudonana is genetically engineered to display an IgG-binding domain of protein G on the biosilica surface, enabling attachment of cell-targeting antibodies. Neuroblastoma and B-lymphoma cells are selectively targeted and killed by biosilica displaying specific antibodies sorbed with drug-loaded nanoparticles. Treatment with the same biosilica leads to tumour growth regression in a subcutaneous mouse xenograft model of neuroblastoma. These data indicate that genetically engineered biosilica frustules may be used as versatile ‘backpacks’ for the targeted delivery of poorly water-soluble anticancer drugs to tumour sites.

16 February 2025 in Molecular Therapy - Methods & Clinical Development
Verified
Journal Article
Open access
MHMahboubeh Hosseini-Kharat
Mahboubeh Hosseini-Kharat
KBKristen E. Bremmell
Kristen E. Bremmell
Clive PrestidgeClive Prestidge
Clive Prestidge
Lipid nanoparticles (LNPs) are now highly effective transporters of nucleic acids to the liver. This liver-specificity is largely due to their association with certain serum proteins, most notably apolipoprotein E (ApoE), which directs them to liver cells by binding to the low-density lipoprotein (LDL) receptors on hepatocytes. The liver's distinct anatomy, with its various specialized cell types, also influences how LNPs are taken up from the circulation, cleared, and how effective they are in delivering treatments. In this review, we consider factors that facilitate LNP's effective liver targeting and explore the latest advances in liver-targeted LNP technologies. Understanding how LNPs are targeted to the liver can help for effective design and optimization of nanoparticle-based therapies. Comprehension of the cellular interaction and biodistribution of LNPs not only leads to better treatments for liver diseases but also delivers insight for directing nanoparticles to other tissues, potentially broadening their range of therapeutic applications.

1 November 2013 in Journal of Controlled Release
Verified
Journal Article
Closed access
VBVaskor Bala
Vaskor Bala
SRShasha Rao
Shasha Rao
Ben BoydBen Boyd
Ben Boyd
Clive PrestidgeClive Prestidge
Clive Prestidge

1 December 2019 in Biomaterials
Verified
Journal Article
Closed access
LDLudivine C. Delon
Ludivine C. Delon
ZGZhaobin Guo
Zhaobin Guo
AOAnna Oszmiana
Anna Oszmiana
CCChia-Chi Chien
Chia-Chi Chien
RGRachel Gibson
Rachel Gibson
BTBenjamin Thierry
Benjamin Thierry