IN VIVO neuroimaging has provided compelling evidence for structural^1-3 and functional^4,5 brain abnormalities in schizophrenia. Findings of enlarged lateral ventricles, third ventricles, and cortical sulcal cerebrospinal fluid (CSF) spaces; reductions in medial temporal lobe structures and frontal lobes; and abnormalities in subcortical structures have been replicated fairly consistently in many magnetic resonance imaging (MRI) studies.³ However, except for the association between poor outcome and enlarged lateral ventricles, the significance of the other commonly replicated brain abnormalities on functional outcome in schizophrenia remains uncertain.⁶ Furthermore, the onset and longitudinal evolution of these anomalies during the course of schizophrenia have not been well characterized.