Oliver Kepp

Dr. Oliver Kepp

Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Villejuif, France;
+2
orcid

Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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23 January 2018 in Cell Death & Differentiation
Verified
Journal Article
Open access
Lorenzo GalluzziLorenzo Galluzzi
Lorenzo Galluzzi
IVIlio Vitale
Ilio Vitale
SAStuart A. Aaronson
Stuart A. Aaronson
JAJohn M. Abrams
John M. Abrams
DADieter Adam
Dieter Adam
Guido KroemerGuido Kroemer
Guido Kroemer
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

21 March 2013 in Annual Review of Immunology
Verified
Journal Article
Closed access
Guido KroemerGuido Kroemer
Guido Kroemer
LGLorenzo Galluzzi
Lorenzo Galluzzi
OKOliver Kepp
Oliver Kepp
LZLaurence Zitvogel
Laurence Zitvogel
Depending on the initiating stimulus, cancer cell death can be immunogenic or nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the cell surface as well as the release of soluble mediators, occurring in a defined temporal sequence. Such signals operate on a series of receptors expressed by dendritic cells to stimulate the presentation of tumor antigens to T cells. We postulate that ICD constitutes a prominent pathway for the activation of the immune system against cancer, which in turn determines the long-term success of anticancer therapies. Hence, suboptimal regimens (failing to induce ICD), selective alterations in cancer cells (preventing the emission of immunogenic signals during ICD), or defects in immune effectors (abolishing the perception of ICD by the immune system) can all contribute to therapeutic failure. We surmise that ICD and its subversion by pathogens also play major roles in antiviral immune responses.

17 October 2016 in Nature Reviews Immunology
Verified
Journal Article
Closed access
PDF file
LGLorenzo Galluzzi
Lorenzo Galluzzi
ABAitziber Buqué
Aitziber Buqué
OKOliver Kepp
Oliver Kepp
LZLaurence Zitvogel
Laurence Zitvogel
Guido KroemerGuido Kroemer
Guido Kroemer

5 September 2011 in Oncogene
Verified
Journal Article
Closed access
PDF file
LGL Galluzzi
L Galluzzi
LSLaura SENOVILLA
Laura SENOVILLA
IVIlio Vitale
Ilio Vitale
JMJ Michels
J Michels
IMI Martins
I Martins
Guido KroemerGuido Kroemer
Guido Kroemer

15 July 2011 in Cell Death & Differentiation
Verified
Journal Article
Closed access
PDF file
LGL Galluzzi
L Galluzzi
IVIlio Vitale
Ilio Vitale
JAJ M Abrams
J M Abrams
EAE S Alnemri
E S Alnemri
EBE H Baehrecke
E H Baehrecke
Guido KroemerGuido Kroemer
Guido Kroemer

1 December 2015 in Cancer Cell
Verified
Journal Article
Closed access
LGLorenzo Galluzzi
Lorenzo Galluzzi
ABAitziber Buqué
Aitziber Buqué
OKOliver Kepp
Oliver Kepp
LZLaurence Zitvogel
Laurence Zitvogel
Guido KroemerGuido Kroemer
Guido Kroemer