Hung-Yi Chuang's main research interests are Lead (Pb) Biomarkers, Oxidative stress, and Chronic Diseases. The purpose of his research is to test hypotheses that study the lead toxicity to kidney function, blood pressure, cardiovascular diseases, metabolic syndrome, cognitive performance, and other measures of autonomic nervous function; and the potential modifying influence of candidate genetic polymorphisms related to oxidative stress, enzyme activity, and cholesterol metabolism. The second part of the research is gene-lead (Pb) Interactions. This research aims to discover and validate novel genes through gene over-expression tools in lead (Pb)-exposed workers.