We demonstrate the first reported methodology using nanowires that unveils massive numbers of cancer-related urinary microRNAs.

We report magnetic and transport properties of ${\mathrm{La}}_{1-x}{\mathrm{Ba}}_x{\mathrm{MnO}}_3$ $(x=0.05\mathrm{}–0.33)$ epitaxial thin films. Compared with the corresponding bulk materials, the ferromagnetic transition temperature is reduced in the compressive strained ${\mathrm{La}}_{1-x}{\mathrm{Ba}}_x{\mathrm{MnO}}_3$ thin films with $x=0.3\mathrm{}$ and 0.33, but enhanced significantly in the tensile strained thin films with $x<~\mathrm{0.2.}$ Especially, ferromagnetism and low field colossal magnetoresistance effect were observed around room temperature in $x=0.1\mathrm{}$ thin film, and as $x=0.05,$ a spin-canting insulating state in bulk shifts to ferromagnetic metallic state in thin film. The phase diagram of ${\mathrm{La}}_{1-x}{\mathrm{Ba}}_x{\mathrm{MnO}}_3$ thin films was obtained, and strain effect on these novel properties was discussed.

Two paradigm shifts in DNA sequencing technologies—from bulk to single molecules and from optical to electrical detection—are expected to realize label-free, low-cost DNA sequencing that does not require PCR amplification. It will lead to development of high-throughput third-generation sequencing technologies for personalized medicine. Although nanopore devices have been proposed as third-generation DNA-sequencing devices, a significant milestone in these technologies has been attained by demonstrating a novel technique for resequencing DNA using electrical signals. Here we report single-molecule electrical resequencing of DNA and RNA using a hybrid method of identifying single-base molecules via tunneling currents and random sequencing. Our method reads sequences of nine types of DNA oligomers. The complete sequence of 5′-UGAGGUA-3′ from the let-7 microRNA family was also identified by creating a composite of overlapping fragment sequences, which was randomly determined using tunneling current conducted by single-base molecules as they passed between a pair of nanoelectrodes.