Dr. Frank Richard Schubert
School of the Environment and Life Sciences, University of Portsmouth, Portsmouth, UK
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Academic Career Length
36Years (1991-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 November 1998 in Developmental Biology
Journal Article
PTPatrick Tremblay
Patrick TremblaySDSusanne Dietrich
Susanne Dietrich
Mathias MERICSKAYFrank Richard SchubertZLZhenlin Li
Zhenlin LiDPDenise Paulin
Denise Paulin
1 May 2002 in Developmental Biology
Journal Article
Susan C. ChapmanFrank Richard SchubertGSGary C. Schoenwolf
Gary C. Schoenwolf
ALAndrew Lumsden
Andrew Lumsden
1 December 2001 in Development
Journal Article
JMJuan Pedro Martinez-Barbera
Juan Pedro Martinez-BarberaMSMassimo Signore
Massimo Signore
PBPietro Pilo Boyl
Pietro Pilo BoylEPEduardo Puelles
Eduardo PuellesDADario Acampora
Dario Acampora
ASAntonio Simeone
Antonio Simeone +3
The anterior neural ridge (ANR), and the isthmic organiser (IsO) represent two signalling centres possessing organising properties necessary for forebrain (ANR) as well as midbrain and rostral hindbrain (IsO) development. An important mediator of ANR and IsO organising property is the signalling molecule FGF8. Previous work has indicated that correct positioning of the IsO and Fgf8 expression in this domain is controlled by the transcription factors Otx2 and Gbx2. In order to provide novel insights into the roles of Otx2 and Gbx2, we have studied mutant embryos carrying different dosages of Otx2, Otx1 and Gbx2. Embryos deficient for both OTX2 and GBX2 proteins (hOtx12/hOtx12; Gbx2–/–) show abnormal patterning of the anterior neural tissue, which is evident at the presomite-early somite stage prior to the onset of Fgf8 neuroectodermal expression. Indeed, hOtx12/hOtx12; Gbx2–/– embryos exhibit broad co-expression of early forebrain, midbrain and rostral hindbrain markers such as hOtx1, Gbx2, Pax2, En1 and Wnt1 and subsequently fail to activate forebrain and midbrain-specific gene expression. In this genetic context, Fgf8 is expressed throughout the entire anterior neural plate, thus indicating that its activation is independent of both OTX2 and GBX2 function. Analysis of hOtx12/hOtx12; Gbx2–/– and Otx1+/–; Otx2+/– mutant embryos also suggests that FGF8 cannot repress Otx2 without the participation of GBX2. Finally, we report that embryos carrying a single strong hypomorphic Otx2 allele (Otx2λ) in an Otx2 and Gbx2 null background (Otx2λ/–; Gbx2–/–) recover both the headless phenotype exhibited by Otx2λ/– embryos and forebrain- and midbrain-specific gene expression that is not observed in hOtx12/hOtx12; Gbx2–/– mutants. Together, these data provide novel genetic evidence indicating that OTX2 and GBX2 are required for proper segregation of early regional identities anterior and posterior to the mid-hindbrain boundary (MHB) and for conferring competence to the anterior neuroectoderm in responding to forebrain-, midbrain- and rostral hindbrain-inducing activities.
31 December 1993 in Mechanisms of Development
Journal Article
SDSusanne Dietrich
Susanne DietrichFrank Richard SchubertPGPeter Gruss
Peter Gruss
1 September 2003 in Developmental Cell
Journal Article
LALúcia E Alvares
Lúcia E Alvares
Frank Richard SchubertCTColin Thorpe
Colin Thorpe
RMRoy C Mootoosamy
Roy C Mootoosamy
LCLouise Cheng
Louise ChengSDSusanne Dietrich
Susanne Dietrich +2
1 January 1993 in Proceedings of the National Academy of Sciences
Journal Article
The developmental control genes containing an Antennapedia-type homeobox are clustered in insects and vertebrates. The evolution of these genes was studied by the construction of evolutionary trees and by statistical geometry in sequence space. The comparative analysis of the homeobox sequences reveals the subdivision of the Antennapedia-type homeobox genes into three classes early in metazoan evolution. This observation suggests an important function of these genes even in the most primitive metazoans. Subsequent duplication events generated a cluster of at least five homeobox genes in the last common ancestor of insects and vertebrates. These genes later independently gave rise to the 13 groups of paralogous genes in vertebrates and to the 11 Antennapedia-type genes in the Drosophila complexes.
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