In this article, entropy generation on MHD Casson nanofluid over a porous Stretching/Shrinking surface has been investigated. The influences of nonlinear thermal radiation and chemical reaction have also taken into account. The governing Casson nanofluid flow problem consists of momentum equation, energy equation and nanoparticle concentration. Similarity transformation variables have been used to transform the governing coupled partial differential equations into ordinary differential equations. The resulting highly nonlinear coupled ordinary differential equations have been solved numerically with the help of Successive linearization method (SLM) and Chebyshev spectral collocation method. The impacts of various pertinent parameters of interest are discussed for velocity profile, temperature profile, concentration profile and entropy profile. The expression for local Nusselt number and local Sherwood number are also analyzed and discussed with the help of tables. Furthermore, comparison with the existing is also made as a special case of our study.