Stefano Orlando

Dr. Stefano Orlando

Tor Vergata University Rome Italy, Department Biomedicine and Prevention

Research Focus & Metrics

Academic Career Length

17Years (2010-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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14 December 2016 in PLOS ONE
Verified
Journal Article
Open access
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JLJacopo M. Legramante
Jacopo M. Legramante
LMLaura Morciano
Laura Morciano
FLFrancesca Lucaroni
Francesca Lucaroni
FGFrancesco Gilardi
Francesco Gilardi
ECEmanuele Caredda
Emanuele Caredda
Leonardo PalombiLeonardo Palombi
Leonardo Palombi
The elderly, who suffer from multiple chronic diseases, represent a substantial proportion of Emergency Department (ED) frequent users, thus contributing to ED overcrowding, although they could benefit from other health care facilities, if those were available. The aim of this study was to evaluate and characterize hospital visits of older patients (age 65 or greater) to the ED of a university teaching hospital in Rome from the 1st of January to the 31st of December 2014, in order to identify clinical and social characteristics potentially associated with “elderly frequent users”. A retrospective study was performed during the calendar year 2014 (1st January 2014 – 31st December 2014) analyzing all ED admissions to the University Hospital of Rome Tor Vergata. Variables collected included age, triage code, arrival data, discharge diagnosis, and visit outcome. We performed a risk analysis using univariate binary logistic regression models. A total number of 38,016 patients accessed the ED, generating 46,820 accesses during the study period, with an average of 1.23 accesses for patient. The elderly population represented a quarter of the total ED population and had an increased risk of frequent use (OR 1.5: CI 1.4–1.7) and hospitalization (OR 3.8: CI 3.7–4). Moreover, they showed a greater diagnostic complexity, as demonstrated by the higher incidence of yellow and red priority codes compared to other ED populations (OR 3.1: CI 2.9–3.2). Older patients presented clinical and social characteristics related to the definition of “elderly frail frequent users”. The fact that a larger number of hospitalizations occurred in such patients is indirect evidence of frailty in this specific population, suggesting that hospital admissions may be an inappropriate response to frailty, especially when continued care is not established. Enhancement of continuity of care, establishment of a tracking system for those who are at greater risk of visiting the ED and evaluating fragile individuals should be the highest priority in addressing ED frequent usage by the elderly.

1 January 2017 in Archives of Gerontology and Geriatrics
Verified
Journal Article
Closed access
GLGiuseppe Liotta
Giuseppe Liotta
Rónán O'CaoimhRónán O'Caoimh
Rónán O'Caoimh
FGFrancesco Gilardi
Francesco Gilardi
MPMaria Grazia Proietti
Maria Grazia Proietti
GRGennaro Rocco
Gennaro Rocco
MMMaria Cristina Marazzi
Maria Cristina Marazzi

GLGiuseppe Liotta
Giuseppe Liotta
MIMaria Chiara Inzerilli
Maria Chiara Inzerilli
Leonardo PalombiLeonardo Palombi
Leonardo Palombi
OMOlga Madaro
Olga Madaro
SOStefano Orlando
Stefano Orlando
MMMaria Cristina Marazzi
Maria Cristina Marazzi
This study focuses on the impact of a program aimed at reducing heat-related mortality among older adults residing in central Rome by counteracting social isolation. The mortality of citizens over the age of 75 living in three Urban Areas (UAs) located in central Rome is compared with that of the residents of four adjacent UAs during the summer of 2015. The data, broken down by UA, were provided by the Statistical Office of the Municipality of Rome, which gathers them on a routine basis. During the summer of 2015, 167 deaths were recorded in those UAs in which the Long Live the Elderly (LLE) program was active and 169 in those in which it was not, implying cumulative mortality rates of 25‰ (SD ± 1.4; Cl 95%: 23–29) and 29‰ (SD ± 6.7; Cl 95%: 17–43), respectively. Relative to the summer of 2014, the increase of deaths during the summer of 2015 was greater in UAs in which the LLE program had not been implemented (+97.3% vs. +48.8%). In conclusion, the paper shows the impact of a community-based active monitoring program, focused on strengthening individual relationship networks and the social capital of the community, on mortality in those over 75 during heat waves.

21 May 2020 in PLOS ONE
Verified
Journal Article
Open access
PDF file
GLGiuseppe Liotta
Giuseppe Liotta
MMMaria Cristina Marazzi
Maria Cristina Marazzi
SOStefano Orlando
Stefano Orlando
LPLeonardo Palombi
Leonardo Palombi
Italy was one of the first European countries affected by the new coronavirus (COVID-19) pandemic, with over 105,000 infected people and close to 13,000 deaths, until March 31st. The pandemic has hit especially hard because of the country's demographic structure, with a high percentage of older adults. The authors explore the possibility, recently aired in some studies, of extensive intergenerational contact as a possible determinant of the severity of the pandemic among the older Italian adults. We analyzed several variables to test this hypothesis, such as the percentage of infected patients aged >80 years, available nursing home beds, COVID-19 incidence rate, and the number of days from when the number of positive tests exceeded 50 (epidemic maturity). We also included in the analysis mean household size and percentage of households comprising one person, in the region. Paradoxically, the results are opposite of what was previously reported. The pandemic was more severe in regions with higher family fragmentation and increased availability of residential health facilities.

27 November 2020 in Nutrients
Verified
Journal Article
Open access
PDF file
SMStefania Moramarco
Stefania Moramarco
LMLaura Morciano
Laura Morciano
LMLuca Morucci
Luca Morucci
MMMario Messinese
Mario Messinese
Paola GualtieriPaola Gualtieri
Paola Gualtieri
Leonardo PalombiLeonardo Palombi
Leonardo Palombi
Serum albumin levels are strongly associated with the morbidity, prognosis, and mortality rates of patients with hypoalbuminemia, which is a frequent problem during hospitalization. An observational retrospective study was carried out to analyze changes in albumin levels in hospitalized patients at the “Fondazione Policlinico Tor Vergata—PTV” in 2018. The prevalence of preexisting hypoalbuminemia at the time of discharge from hospital was investigated using a sample of 9428 patients. Information was collected from the discharge files recorded in the central informatics system of the hospital. Analysis of albumin levels at admission and at discharge was conducted by classes of albuminemia and then stratified by age. At the time of admission, hypoalbuminemia was found to be present in more than half of the sample, with no sex differences. The serum albumin level tended to decrease with age, with pathologic levels appearing from 50 years and progressive worsening thereafter. The condition of marked and mild hypoalbuminemia was more prevalent in patients over 65 years of age. Our findings suggest that hypoalbuminemia should be considered a dangerous condition in itself and a serious public health problem. We aimed to emphasize the role of albumin as useful marker of the in-hospital malnutrition and frailty, to be integrated in the routinely assessment of patients for reconsidering ad hoc healthcare pathways after discharge from hospital, especially when dealing with fragile populations.

SOStefano Orlando
Stefano Orlando
CMClaudia Mosconi
Claudia Mosconi
CSCarolina De Santo
Carolina De Santo
Leonardo Emberti GialloretiLeonardo Emberti Gialloreti
Leonardo Emberti Gialloreti
MIMaria Chiara Inzerilli
Maria Chiara Inzerilli
GLGiuseppe Liotta
Giuseppe Liotta
Background: Heat waves are correlated with increased mortality in the aged population. Social isolation is known as a vulnerability factor. This study aims at evaluating the correlation between an intervention to reduce social isolation and the increase in mortality in the population over 80 during heat waves. Methods: This study adopted a retrospective ecologic design. We compared the excess mortality rate (EMR) in the over-80 population during heat waves in urban areas of Rome (Italy) where a program to reduce social isolation was implemented, to others where it was not implemented. We measured the mortality of the summer periods from 2015 to 2019 compared with 2014 (a year without heat waves). Winter mortality, cadastral income, and the proportion of people over 90 were included in the multivariate Poisson regression. Results: The EMR in the intervention and controls was 2.70% and 3.81%, respectively. The rate ratio was 0.70 (c.i. 0.54–0.92, p-value 0.01). The incidence rate ratio (IRR) of the interventions, with respect to the controls, was 0.76 (c.i. 0.59–0.98). After adjusting for other variables, the IRR was 0.44 (c.i. 0.32–0.60). Conclusions: Reducing social isolation could limit the impact of heat waves on the mortality of the elderly population.