I really appreciated reading this review by Kallerman et al. The text is nicely presented in a simple and didatic way providing important information on parasite-host cell relationship.

However there is a point that I would like to discuss. In the text the authors claimed that during the infection Toxoplasma gondii impaired the UPR by inducing Calcium eflux from ER leading the activation of IRE 1. I think that this affirmation should be reconsidered. IRE1 is an important endoplasmatic reticulum stress sensor that activates the UPR response. In the work cited in this review (reference 69) "Toxoplasma gondii co-opts the unfolded protein to enhance migration and dissemination of infected host cells" by Augusto et al(2020), the authors demonstrated that T.gondii triggered the UPR ( rather than impairing it), inducing the Calcium eflux from ER and the activation of IRE1. Interestingly these authors also demonstrated a non-canonical role of activated IRE1 associated with the remodeling of host cell cytoskeleton promoting the host cell migration facilitating the parasite dissemination into multiple organs. Despite this small inconsistency this is an excellent review.