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Arizona State University
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Members
Total: 75 members
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Latest Publications
Journal Article
Computational and Structural Biotechnology Journal
Published: 01 December 2024 in Computational and Structural Biotechnology Journal

Gene transcription is an essential process involved in all aspects of cellular functions with significant impact on biological traits and diseases. This process is tightly regulated by multiple elements that co-operate to jointly modulate the transcription levels of target genes. To decipher the complicated regulatory network, we present a novel multi-view attention-based deep neural network that models the relationship between genetic, epigenetic, and transcriptional patterns and identifies co-operative regulatory elements (COREs). We applied this new method, named DeepCORE, to predict transcriptomes in various tissues and cell lines, which outperformed the state-of-the-art algorithms. Furthermore, DeepCORE contains an interpreter that extracts the attention values embedded in the deep neural network, maps the attended regions to putative regulatory elements, and infers COREs based on correlated attentions. The identified COREs are significantly enriched with known promoters and enhancers. Novel regulatory elements discovered by DeepCORE showed epigenetic signatures consistent with the status of histone modification marks.

ACS Style

Pramod Bharadwaj Chandrashekar; Hai Chen; Matthew Lee; Navid Ahmadinejad; Li Liu. DeepCORE: An interpretable multi-view deep neural network model to detect co-operative regulatory elements. Computational and Structural Biotechnology Journal 2024, 23, 679 -687.

AMA Style

Pramod Bharadwaj Chandrashekar, Hai Chen, Matthew Lee, Navid Ahmadinejad, Li Liu. DeepCORE: An interpretable multi-view deep neural network model to detect co-operative regulatory elements. Computational and Structural Biotechnology Journal. 2024; 23 ():679-687.

Chicago/Turabian Style

Pramod Bharadwaj Chandrashekar; Hai Chen; Matthew Lee; Navid Ahmadinejad; Li Liu. 2024. "DeepCORE: An interpretable multi-view deep neural network model to detect co-operative regulatory elements." Computational and Structural Biotechnology Journal 23, no. : 679-687.

Journal Article
Resources, Conservation & Recycling Advances
Published: 01 October 2024 in Resources, Conservation & Recycling Advances

The imperative to mitigate carbon emissions and seek sustainable alternatives to cementitious materials has driven the advancement of geopolymer binders, which are inorganic binders of aluminosilicate industrial-waste materials activated by alkaline agents. The use of geopolymers carries the potential for significant reductions in greenhouse gas emission. Furthermore, the incorporation of plastic waste as aggregates addresses not only resource conservation but also environmental sustainability. This study conducted a comprehensive life-cycle assessment of the use of geopolymers from fly ash as a precursor with polyethylene terephthalate (PET) waste as a substitute for natural aggregates. It was observed that when replacing natural aggregates with PET waste to the maximum extent, the global warming potential (GWP) in the category of emissions related to aggregate preparation increased by 16.7 %. This increase was attributed to significant emissions generated during PET processing, including activities such as washing and grinding. The total GWP to produce one cubic meter of geopolymer mixture was 643.55 kgCO2-e without PET aggregates and 667.86 kgCO2-e with maximum use of PET aggregates. The optimization of energy-intensive PET preparation processes led to a remarkable reduction of 19.63 % for production of geopolymer mixture with maximum use of PET aggregates. These findings show the potential for improved sustainability in the production of geopolymer mixtures and emphasize the critical role of optimizing the production processes in mitigating their environmental impact.

ACS Style

Georgy Lazorenko; Ekaterina Kravchenko; Anton Kasprzhitskii; Elham H. Fini. An evaluation of the environmental impact and energy efficiency of producing geopolymer mortar with plastic aggregates. Resources, Conservation & Recycling Advances 2024, 22 .

AMA Style

Georgy Lazorenko, Ekaterina Kravchenko, Anton Kasprzhitskii, Elham H. Fini. An evaluation of the environmental impact and energy efficiency of producing geopolymer mortar with plastic aggregates. Resources, Conservation & Recycling Advances. 2024; 22 ():.

Chicago/Turabian Style

Georgy Lazorenko; Ekaterina Kravchenko; Anton Kasprzhitskii; Elham H. Fini. 2024. "An evaluation of the environmental impact and energy efficiency of producing geopolymer mortar with plastic aggregates." Resources, Conservation & Recycling Advances 22, no. : .

Journal Article
Practice Periodical on Structural Design and Construction
Published: 01 August 2024 in Practice Periodical on Structural Design and Construction

Based on construction project data provided by the Connecticut Department of Transportation (CTDOT), this investigation provides an overview of transportation project delivery impactors dur...

ACS Style

Muhammad Rauf Shaker; Cliff Schexnayder; Byungik Chang. Risk Analysis of Connecticut Department of Transportation Projects during the COVID-19 Pandemic. Practice Periodical on Structural Design and Construction 2024, 29, 04024016 .

AMA Style

Muhammad Rauf Shaker, Cliff Schexnayder, Byungik Chang. Risk Analysis of Connecticut Department of Transportation Projects during the COVID-19 Pandemic. Practice Periodical on Structural Design and Construction. 2024; 29 (3):04024016.

Chicago/Turabian Style

Muhammad Rauf Shaker; Cliff Schexnayder; Byungik Chang. 2024. "Risk Analysis of Connecticut Department of Transportation Projects during the COVID-19 Pandemic." Practice Periodical on Structural Design and Construction 29, no. 3: 04024016.

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Latest Conferences
Tempe, AZ
Date: 11 September 2023
Tempe, Arizona, United State
Date: 8–10 March 2020
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