DNA molecules direct the swelling of cross-linked hydrogels with shape changes in response to different biomolecular signals.

A variety of biomimetic stimuli-responsive soft grippers that can be utilized as intelligent actuators, sensors, or biomedical tools have been developed. This review covers stimuli-responsive materials, fabrication methods, and applications of soft grippers. This review specifically describes the current research progress in stimuli-responsive grippers composed of N-isopropylacrylamide hydrogel, thermal and light-responding liquid crystalline and/or pneumatic-driven shape-morphing elastomers. Furthermore, this article provides a brief overview of high-throughput assembly methods, such as photolithography and direct printing approaches, to create stimuli-responsive soft grippers. This review primarily focuses on stimuli-responsive soft gripping robots that can be utilized as tethered/untethered multiscale smart soft actuators, manipulators, or biomedical devices.

Time-dependent shape-transferable soft robots are important for various intelligent applications in flexible electronics and bionics. Four-dimensional (4D) shape changes can offer versatile functional advantages during operations to soft robots that respond to external environmental stimuli, including heat, pH, light, electric, or pneumatic triggers. This review investigates the current advances in multiscale soft robots that can display 4D shape transformations. This review first focuses on material selection to demonstrate 4D origami-driven shape transformations. Second, this review investigates versatile fabrication strategies to form the 4D mechanical structures of soft robots. Third, this review surveys the folding, rolling, bending, and wrinkling mechanisms of soft robots during operation. Fourth, this review highlights the diverse applications of 4D origami-driven soft robots in actuators, sensors, and bionics. Finally, perspectives on future directions and challenges in the development of intelligent soft robots in real operational environments are discussed.

Biodegradable soft robots have been proposed for a variety of intelligent applications in soft robotics, flexible electronics, and bionics. Biodegradability offers an extraordinary functional advantage to soft robots for operations accompanying smart shape transformation in response to external stimuli such as heat, pH, and light. This review primarily surveyed the current advanced scientific and engineering strategies for integrating biodegradable materials within stimuli-responsive soft robots. It also focused on the fabrication methodologies of multiscale biodegradable soft robots, and highlighted the role of biodegradable soft robots in enhancing the multifunctional properties of drug delivery capsules, biopsy tools, smart actuators, and sensors. Lastly, the current challenges and perspectives on the future development of intelligent soft robots for operation in real environments were discussed.