Although combustible cigarettes (hereinafter referred to as cigarettes) continue to dominate the tobacco product market in the United States, the emergence and rapid growth of electronic cigarettes (e-cigarettes) in the past decade has led to a transformative change in the US tobacco market—a rapid increase in awareness and use of e-cigarettes among youth and adults that coincided with a decline in cigarette smoking.
1-3 This transformation has been accelerated in recent years by the emergence of new generations of e-cigarettes, such as JUUL e-cigarettes (JUUL Labs).
4,5 The exponential growth in e-cigarettes has prompted a renewed interest in the tobacco harm reduction approach, which aims to curb the smoking epidemic rapidly by encouraging smokers to switch to low-risk tobacco products such as e-cigarettes.
6 The potential role that e-cigarettes may play in reducing the harm caused by tobacco is still the subject of heated debate.
6,7