Following a Pharm.D and a specialized degree in clinical biochemistry in 1984 in Rennes University, France, my first research interests were the design of tumor models in laboratory rodents and the characterization/applications of new Nuclear Magnetic Resonance contrast agents for proton MRI (PhD 1988, postdoc, Dept of Radiology, MGH, Boston, USA). From 1995 to 2001, I extended the scope of NMR relaxometry to the study of water states and dynamic properties in protein solutions, biofluids, normal preneoplastic and neoplastic tissues, and organisms under various developments (seeds, fish eggs, and embryos). These studies led me to investigate the quantitative and qualitative changes in the different water phases in mitochondria, and implications of diet in the biophysics of water in tissues during carcinogenesis. In this context, some beneficial effects of combinations of phytochemicals (including curcuma extract) were observed for the prevention of experimental models of myeloma in mice and glioblastoma in rats. From 2008, I established a biocollection of preneoplastic and neoplastic cell lines and experimental models of malignant mesothelioma in immunocompetent rats for both basic research and the evaluation of various new strategies of treatment. With this background, I presently work on the identification of biomarkers of tumorigenesis, cancer invasiveness, and therapeutic efficacy of curcumin in vivo by quantitative proteomics (mass spectrometry = SWATH-MS).