Triple‐negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 and is characterized by its aggressive nature, lack of targets for targeted therapies, and early peak of recurrence. Due to these specific characteristics, chemotherapy does not usually yield substantial improvements and new target therapies and alternative strategies are needed. The beneficial responses of TNBC survivors to regular exercise, including a reduction in the rate of tumor growth, are becoming increasingly apparent. Physiological adaptations to exercise occur in skeletal muscle but have an impact on the entire body through systemic control of energy homeostasis and metabolism, which in turn influence the TNBC tumor microenvironment. Gaining insights into the causal mechanisms of the therapeutic cancer control properties of regular exercise is important to improve the prescription and implementation of exercise and training in TNBC survivors. Here, we provide new evidence of the effects of exercise on TNBC prevention, control, and outcomes, based on the inhibition of the phosphatidylinositol‐3‐kinase (PI3K)/protein kinase B (PKB also known as Akt)/mammalian target of rapamycin (mTOR) (PI3K‐Akt‐mTOR) signaling. These findings have wide‐ranging clinical implications for cancer treatment, including recurrence and case management.

Low back pain (LBP) is a common ailment in competitive athletes. Although the association between limited range of motion (ROM) and prevalence of LBP has been widely investigated in other sports, there is no research about this topic in inline hockey (IH). The main purposes of this study in IH players were (1) to analyze the association between hip ROM and LBP and (2) to establish a diagnostic cutoff for ROM of high risk of LBP. Twenty elite IH players from the two Spanish National Teams (male and female) were assessed for passive maximum hip ROMs; the movement evaluated were the hip external [HER] and internal [HIR] rotation, hip flexion with flexed [HF-KF] and extended [HF-KE] knee, hip adduction with flexed hip [HAD-HF], hip abduction with neutral [HAB] and flexed [HAB-HF] hip, and hip extension [HE]. LBP was retrospectively monitored for the last 12 months before the date of ROM assessment by using a questionnaire. The data were analyzed via a binary logistic regression and receiver operating characteristic curves. The 70% of players had developed LBP during the retrospective study period. Significant differences between LBP group and asymptomatic group for HER (p = 0.013, d [Cohen’s effect size] = 1.17) and hip total rotation [HTR] (p = 0.032, d [Cohen’s effect size] = 1.05) were observed. The cutoff points with the greatest discriminatory capacity were 56.5° for HER and 93° for HTR ROMs.

Limited ranges of motion (ROM) have been considered as a relevant risk factor for team sports injuries. The main purposes of the current study were to describe the lower extremity ROM profile, muscular tightness and asymmetries in elite inline hockey players and to examine sex-related differences. Twenty professional inline hockey players from 2 Spanish National Teams (male and female) were measured of passive hip extension [HE], hip adduction with hip flexed 90° [HAD-HF], hip flexion with the knee flexed [HF-KF] and extended [HF-KE], hip abduction with the hip neutral [HAB] and hip flexed 90° [HAB-HF], hip external [HER] and internal [HIR] rotation, knee flexion [KF], ankle dorsiflexion with the knee flexed [ADF-KF] and extended [ADF-KE] ROMs of the dominant and non-dominant leg ROMs were taken. A paired t-test was carried out to assess asymmetries. ROM values were classified as “normal versus tightness”, and “normal versus asymmetry” according to the proposed reference values. The effect size for each variable was analyzed. Male team exhibited asymmetry in HF-KF (133.2° dominant vs. 129.8° non-dominant; p = 0.042; d = 0.7243 [moderate effect sizes]) and female team in ADF-KF (38.8° dominant vs. 41.0 non-dominant; p = 0.001; d = 0.6 [moderate effect sizes]) and HAB ROM (41.2° dominant vs. 38.8 non-dominant; p = 0.005; d = 1.1767 [moderate effect sizes]). Male players reported asymmetry in HAD-HF (n = 5), HER (n = 4) and HE (n = 3), whereas female players presented asymmetries in HER (n = 4), HE (n = 3) and KF (n = 2). Overall, 20–100% of all participants showed limited KF, HF_KE, HIR, HE, ADF_KF, HAD-HF, HF-KF, ADF_KE, HTR and HER ROM. The results of this study reinforce the requirement of prescribing exercises aimed at improving hip, knee and ankle ROM within everyday inline hockey practices. In addition, as some asymmetries were found, unilateral flexibility training should be considered where appropriate.

During last years the use of new technologies, become crucial to define physical performance, tactics, and technique in football. The physical performance during matches is detected, using video-analysis or GPS system. The aim of this study was to compare external load performance from matches between young professional players (U-21) and professional players from European leagues. Data from U-21 was collected using K-Sport 10 Hz GPS (K-Sport Universal, Italy) using as a sample of three Italian youth teams. Data from professional players are taken from video-analysis gathered from the literature. Were analysed 10 games for each youth teams from Italian Primavera Championship 2016/2017. For every game was used one 10 Hz GPS (K-Sport Universal, Italy) for each player, except goalkeeper and were recorded only data from players that perform all the game.

(1) Background: The kick of the ball in soccer is considered one of the most important technical gestures in soccer. Despite this, there is little evidence on ball-striking performance factors in base soccer. The main objectives of the present study were to identify the potential factors of long-ball kicking (LBK) performance and to determine the target training cut-off for LBK performance in young soccer players. (2) Methods: A cross-sectional observational study was conducted with 31 soccer players, with ages ranging from 12 to 18 years. Age, anthropometric data, sport experience, range of motion (ROM) and maximal isometric strength (MIS) of the lower limb were noted. Kick-of-the-ball performance was assessed by maximum ball displacement per kick. A k-mean cluster analysis determined two groups according to ball-kicking performance: low group (LPG-LBK) and high group (HPG-LBK). (3) Results: Differences were found between both groups in age, body mass, body mass index, leg length and knee flexion ROM (BF10 ≤ 6.33; δ ≥ 0.86 (moderate or higher)). Among the factors discussed above, age was the strongest predictor of ball-striking performance (odds ratio = 2.867; p = 0.003). The optimal cut-off for age predicting those players most likely to have a higher ball-striking performance was determined to be 13.5 years (p = 0.001; area under the curve = 85.3%). (4) Conclusions: Age over 13.5 increases the chances of a higher optimal ball-striking performance. The flexibility (knee flexion ROM) and strength (knee flexors) must be specifically trained in soccer players beginning at an early age.

Background/Objectives: The ROM-SPORT is a test battery for assessing flexibility that measures the range of motion (ROM) in the sport. Restricted or optimal ROM is associated with an increased risk of injury or improved athletic performance, respectively. The aim of the present study was to determine the normative values of the lower limb’s flexibility profile by ROM assessment in female football players. Methods: Lower-limb flexibility (11 ROM tests) was measured using the ROM-SPORT battery in 142 female football players (19.42 ± 4.45 years). The tests were performed at the beginning of the training sessions in the first two weeks of the pre-season. Standardized Z-scores (on a scale of 0 to 100 [T-score]) were calculated from the mean and standard deviation to classify the ROM of each movement into three qualitative categories (poor [>−3 to −2], average or normal [−1 to 1; 68.2%], and optimal [1 to >3]) and a traffic light system to facilitate interpretation of the results. Results: The results show normal (or average) ROM values at 32–37° for ankle dorsiflexion with the knee extended; 37–43° for ankle dorsiflexion with the knee flexed; 46–54° for hip internal rotation; 54–61° for hip external rotation; 31–37° for hip adduction; 70–76° for hip abduction with the hip flexed; 41–45° for hip abduction with the hip neutral; 135–141° for hip flexion; 73–82° for hip flexion with the knee extended; 15–21° for hip extension; 121–132° for knee flexion. The normative data presented in this study can be utilized by researchers and practitioners in the women’s football league in a variety of ways, provided similar data collection methods are used. Conclusions: Flexibility training is recommended to overcome normal or average ROM and optimize athletic performance with lower injury risk in female football players.