Instituto de Tecnología Química (ITQ); Universitat Politècnica de València (UPV); Av. de los Naranjos S/N, Puerta L, Edificio 6C, 46022, Valencia, Spain.
Dr. Luis M. Martínez-Prieto
Instituto de Tecnología Química (ITQ); Universitat Politècnica de València (UPV); Av. de los Naranjos S/N, Puerta L, Edificio 6C, 46022, Valencia, Spain.
We present here the first example of C(sp3)–H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a hydrogen isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.