Rosemary J. Akhurst

Prof. Rosemary J. Akhurst

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA

Research Focus & Metrics

Academic Career Length

40Years (1987-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 October 2001 in Nature Genetics
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Journal Article
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RDRik Derynck
Rik Derynck
RARosemary J. Akhurst
Rosemary J. Akhurst
ABAllan Balmain
Allan Balmain

24 September 2012 in Nature Reviews Drug Discovery
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Journal Article
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RARosemary J. Akhurst
Rosemary J. Akhurst
AHAkiko Hata
Akiko Hata

24 July 2020 in Nature Reviews Clinical Oncology
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Journal Article
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RDRik Derynck
Rik Derynck
STShannon J. Turley
Shannon J. Turley
RARosemary J. Akhurst
Rosemary J. Akhurst

1 August 1996 in Cell
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Journal Article
Closed access
Wei CuiWei Cui
Wei Cui
DFDeborah J Fowlis
Deborah J Fowlis
SBSheila Bryson
Sheila Bryson
EDElizabeth Duffie
Elizabeth Duffie
HIHazel Ireland
Hazel Ireland
RARosemary J. Akhurst
Rosemary J. Akhurst

1 November 2001 in Trends in Cell Biology
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Journal Article
Closed access
RARosemary J. Akhurst
Rosemary J. Akhurst
RDRik Derynck
Rik Derynck

1 January 1991 in Development
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Journal Article
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FMFergus A. Millan
Fergus A. Millan
FDFabienne Denhez
Fabienne Denhez
PKPaturu Kondaiah
Paturu Kondaiah
RARosemary J. Akhurst
Rosemary J. Akhurst
We have compared the expression of the genes encoding transforming growth factors β1, β2 and β3 during mouse embryogenesis from 9.5 to 16.5 days p.c. using in situ hybridisation to cellular RNAs. Each gene has a different expression pattern, which gives some indication of possible biological function in vivo. All three genes appear to be involved in chondro ossification, though each is expressed in a different cell type. Transcripts of each gene are also present in embryonic epithelia. Epithelial expression of TGF β1, β2 and β3 RNA is associated with regions of active morphogenesis involving epithelial-mesenchymal inter actions. In addition, widespread epithelial expression of TGF β2 RNA can be correlated with epithelial differentiation per se. The localisation of TGF β2 RNA in neuronal tissue might also be correlated with differentiation. Finally both TGF β1 and β2 transcripts are seen in regions actively undergoing cardiac septation and valve formation, suggesting some interaction of these growth factors in this developmental process.