The coordination chemistry of magnesium (Mg²⁺) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease—predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry.

Magnesium (Mg²⁺) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully characterized, highly bioavailable, and substantially water-soluble magnesium supplements. To this end, triglycine (HG₃), a tripeptide of the amino acid glycine, was chosen as a chelating ligand for magnesium, given its natural occurrence and water solubility, and entropically-driven metal binding. Herein, we discuss the synthesis, chemical and physical characterization, and cellular uptake of a magnesium triglycine chelate (MgG₃), an octahedral complex with extraordinary water solubility and improved cellular uptake in CaCo-2 cells than select commonly used magnesium supplements.

The development of photocatalytic systems for conversion of CO₂ to energized molecules such as CO presents a fundamental opportunity to exploit an abundant source of raw materials in nature. Re(I)-carbonyl-diimine complexes [Re(CO)₃(diamine)X]^0,+1 are chemically robust and synthetically accessible photo- and redox-active complexes that have been

The development of photocatalytic systems for conversion of CO₂ to energized molecules such as CO presents a fundamental opportunity to exploit an abundant source of raw materials in nature. Re(I)-carbonyl-diimine complexes [Re(CO)₃(diamine)X]^0,+1 are chemically robust and synthetically accessible photo- and redox-active complexes that have been