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Julio Fernández-Garrido
Chair of Healthy, Active and Participatory Aging, Valencia City Council, University of Valencia, 46010 Valencia, Spain

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Editorial
Published: 10 March 2021 in Life
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There are numerous biological, psychological, and social factors that have a more or less prominent impact on the mental health of older adults

ACS Style

Omar Cauli; Rut Navarro-Martínez; Julio Fernández-Garrido. Special Issue “Mental Health Issues and Quality of Life in Older Individuals”. Life 2021, 11, 221 .

AMA Style

Omar Cauli, Rut Navarro-Martínez, Julio Fernández-Garrido. Special Issue “Mental Health Issues and Quality of Life in Older Individuals”. Life. 2021; 11 (3):221.

Chicago/Turabian Style

Omar Cauli; Rut Navarro-Martínez; Julio Fernández-Garrido. 2021. "Special Issue “Mental Health Issues and Quality of Life in Older Individuals”." Life 11, no. 3: 221.

Journal article
Published: 27 January 2021 in Biology
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Nowadays, the appearance of sarcopenia (S) or sarcopenic obesity (SO) is related to aging. According to the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP), the feasibility of using salivary cortisol and testosterone levels was analyzed as diagnostic biomarkers of S or SO. One hundred and ninety non-institutionalized people aged ≥65 years were studied, independent of the activities of daily living (ADLs) (Barthel > 60), and sociodemographic variables were determined together with criteria for the diagnosis of S and SO including grip force, lower body strength, appendicular skeletal muscle mass, physical performance, total body fat percentage, body mass index (BMI), waist circumference, and triceps skinfold, together with the levels of salivary cortisol and testosterone. Our results reflected that women presented a higher prevalence of S and SO (21.2% and 30.2%, respectively). A significant difference was observed between salivary testosterone levels and the age of the participants with differences by sex. Testosterone values in men with S and SO were significantly lower (p = 0.043 and p = 0.048, respectively), which suggests a potential use of the biomarker for diagnostic purposes. No significant differences were shown with cortisol values.

ACS Style

Angela Diago-Galmés; Carlos Guillamón-Escudero; Jose Tenías-Burillo; Jose Soriano; Julio Fernández-Garrido. Salivary Testosterone and Cortisol as Biomarkers for the Diagnosis of Sarcopenia and Sarcopenic Obesity in Community-Dwelling Older Adults. Biology 2021, 10, 93 .

AMA Style

Angela Diago-Galmés, Carlos Guillamón-Escudero, Jose Tenías-Burillo, Jose Soriano, Julio Fernández-Garrido. Salivary Testosterone and Cortisol as Biomarkers for the Diagnosis of Sarcopenia and Sarcopenic Obesity in Community-Dwelling Older Adults. Biology. 2021; 10 (2):93.

Chicago/Turabian Style

Angela Diago-Galmés; Carlos Guillamón-Escudero; Jose Tenías-Burillo; Jose Soriano; Julio Fernández-Garrido. 2021. "Salivary Testosterone and Cortisol as Biomarkers for the Diagnosis of Sarcopenia and Sarcopenic Obesity in Community-Dwelling Older Adults." Biology 10, no. 2: 93.

Journal article
Published: 07 December 2020 in International Journal of Environmental Research and Public Health
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This study is an observational and cross-sectional study on the prevalence of sarcopenic disease in 202 autonomous older adults; 18.8 and 81.2% were men and women, respectively, living in their own homes in Valencia, Spain. Sarcopenia was diagnosed using the criteria and cutting points for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), using the tests: SARC-F, grip strength, sit-to-stand, gait speed, appendicular skeletal muscle mass and short physical performance battery. According to the EWGSOP2 criteria, probable sarcopenia was present in 21.1% and 18.3% of men and women, respectively, and the sum of confirmed and severe sarcopenia was 7.9% and 7.3% in men and in women, respectively. A relationship was shown between the prevalence of the disease and the age of the participants, but no significant differences were found between the sum of confirmed and severe sarcopenia between the sexes, nor a relationship between the amount of muscle mass and the strength of grip. The SARC-F questionnaire diagnosed 40% of the sarcopenia cases present in the study. More thorough research is needed to continue using the EWGSOP2 criteria in different populations to establish a correct prevalence of sarcopenic disease in different populations of the world.

ACS Style

Carlos Guillamón-Escudero; Angela Diago-Galmés; Jose M. Tenías-Burillo; Jose M. Soriano; Julio J. Fernández-Garrido. Prevalence of Sarcopenia in Community-Dwelling Older Adults in Valencia, Spain. International Journal of Environmental Research and Public Health 2020, 17, 9130 .

AMA Style

Carlos Guillamón-Escudero, Angela Diago-Galmés, Jose M. Tenías-Burillo, Jose M. Soriano, Julio J. Fernández-Garrido. Prevalence of Sarcopenia in Community-Dwelling Older Adults in Valencia, Spain. International Journal of Environmental Research and Public Health. 2020; 17 (23):9130.

Chicago/Turabian Style

Carlos Guillamón-Escudero; Angela Diago-Galmés; Jose M. Tenías-Burillo; Jose M. Soriano; Julio J. Fernández-Garrido. 2020. "Prevalence of Sarcopenia in Community-Dwelling Older Adults in Valencia, Spain." International Journal of Environmental Research and Public Health 17, no. 23: 9130.

Journal article
Published: 27 March 2020 in Nutrients
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Treating sarcopenia in older individuals remains a challenge, and nutritional interventions present promising approaches in individuals that perform limited physical exercise. We assessed the efficacy of leucine administration to evaluate whether the regular intake of this essential amino acid can improve muscle mass, muscle strength and functional performance and respiratory muscle function in institutionalized older individuals. The study was a placebo-controlled, randomized, double-blind design in fifty participants aged 65 and over (ClinicalTrials.gov identifier NCT03831399). The participants were randomized to a parallel group intervention of 13 weeks’ duration with a daily intake of leucine (6 g/day) or placebo (lactose, 6 g/day). The primary outcome was to study the effect on sarcopenia and respiratory muscle function. The secondary outcomes were changes in the geriatric evaluation scales, such as cognitive function, functional impairment and nutritional assessments. We also evaluated whether leucine administration alters blood analytical parameters and inflammatory markers. Administration of leucine was well-tolerated and significantly improves some criteria of sarcopenia in elderly individuals such as functional performance measured by walking time (p = 0.011), and improved lean mass index. For respiratory muscle function, the leucine-treated group improved significantly (p = 0.026) in maximum static expiratory force compared to the placebo. No significant effects on functional impairment, cognitive function or nutritional assessment, inflammatory cytokines IL-6, TNF-alpha were observed after leucine administration compared to the placebo. The use of l-leucine supplementation can have some beneficial effects on sarcopenia and could be considered for the treatment of sarcopenia in older individuals.

ACS Style

Francisco M. Martínez-Arnau; Rosa Fonfria -Vivas; Cristina Buigues; Yolanda Castillo; Pilar Molina; Aldert J. Hoogland; Femke Van Doesburg; Leo Pruimboom; Julio Fernández-Garrido; Omar Cauli. Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial. Nutrients 2020, 12, 932 .

AMA Style

Francisco M. Martínez-Arnau, Rosa Fonfria -Vivas, Cristina Buigues, Yolanda Castillo, Pilar Molina, Aldert J. Hoogland, Femke Van Doesburg, Leo Pruimboom, Julio Fernández-Garrido, Omar Cauli. Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial. Nutrients. 2020; 12 (4):932.

Chicago/Turabian Style

Francisco M. Martínez-Arnau; Rosa Fonfria -Vivas; Cristina Buigues; Yolanda Castillo; Pilar Molina; Aldert J. Hoogland; Femke Van Doesburg; Leo Pruimboom; Julio Fernández-Garrido; Omar Cauli. 2020. "Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial." Nutrients 12, no. 4: 932.

Journal article
Published: 06 September 2019 in BMC Health Services Research
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Medication errors are a serious and complex problem in clinical practice, especially in intensive care units whose patients can suffer potentially very serious consequences because of the critical nature of their diseases and the pharmacotherapy programs implemented in these patients. The origins of these errors discussed in the literature are wide-ranging, although far-reaching variables are of particular special interest to those involved in training nurses. The main objective of this research was to study if the level of knowledge that critical-care nurses have about the use and administration of medications is related to the most common medication errors. This was a mixed (multi-method) study with three phases that combined quantitative and qualitative techniques. In phase 1 patient medical records were reviewed; phase 2 consisted of an interview with a focus group; and an ad hoc questionnaire was carried out in phase 3. The global medication error index was 1.93%. The main risk areas were errors in the interval of administration of antibiotics (8.15% error rate); high-risk medication dilution, concentration, and infusion-rate errors (2.94% error rate); and errors in the administration of medications via nasogastric tubes (11.16% error rate). Nurses have a low level of knowledge of the drugs they use the most and with which a greater number of medication errors are committed in the ICU.

ACS Style

Juan Escrivá Gracia; Ricardo Brage Serrano; Julio Fernández Garrido. Medication errors and drug knowledge gaps among critical-care nurses: a mixed multi-method study. BMC Health Services Research 2019, 19, 1 -9.

AMA Style

Juan Escrivá Gracia, Ricardo Brage Serrano, Julio Fernández Garrido. Medication errors and drug knowledge gaps among critical-care nurses: a mixed multi-method study. BMC Health Services Research. 2019; 19 (1):1-9.

Chicago/Turabian Style

Juan Escrivá Gracia; Ricardo Brage Serrano; Julio Fernández Garrido. 2019. "Medication errors and drug knowledge gaps among critical-care nurses: a mixed multi-method study." BMC Health Services Research 19, no. 1: 1-9.

Journal article
Published: 24 July 2019 in Sustainability
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The conventional approach to sustainability is being extended through approaches such as the psychology of sustainability and sustainable development. Under such approaches, the analysis of sustainability also involves understanding improvements in people’s quality of life in environments such as education and learning. Based on this theoretical approach, this study explored the relationships between anxiety, emotional intelligence, and mechanisms for coping with stressful situations. The mediating role of emotional intelligence in the relationship between anxiety and coping mechanisms was also assessed. The anxiety, emotional intelligence, and coping variables were measured using standardized tests administered to students. This cross-sectional study was based on self-reports by health students at universities in Valencia (Spain). The study conformed to the ethical standards established by the Declaration of Helsinki. In total, 434 students participated in the study. The students were aged between 17 and 54 years (M = 21; SD = 0.320). From the perspective of the psychology of sustainability, the results indicate that avoidance coping strategies are positively related to anxiety and are negatively related to emotional intelligence. However, the results also show that approach coping strategies are positively related to emotional intelligence. In addition, the analysis shows the mediating role of emotional intelligence in the relationship between anxiety and coping. This study shows the need to encourage the sustainable development of emotional intelligence among health professionals and to consider this sustainable development when designing education programs for health-related fields.

ACS Style

Ana M. Tur-Porcar; Noemí Cuartero-Monteagudo; Julio Fernández-Garrido. Learning Environments in Health and Medical Studies: The Mediating Role of Emotional Intelligence. Sustainability 2019, 11, 4011 .

AMA Style

Ana M. Tur-Porcar, Noemí Cuartero-Monteagudo, Julio Fernández-Garrido. Learning Environments in Health and Medical Studies: The Mediating Role of Emotional Intelligence. Sustainability. 2019; 11 (15):4011.

Chicago/Turabian Style

Ana M. Tur-Porcar; Noemí Cuartero-Monteagudo; Julio Fernández-Garrido. 2019. "Learning Environments in Health and Medical Studies: The Mediating Role of Emotional Intelligence." Sustainability 11, no. 15: 4011.

Multicenter study
Published: 01 March 2018 in Experimental Gerontology
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Alteration in the immune system such as the number of white blood cells count (WBC) has been associated with frailty syndrome but their role in institutionalized older individuals have been rarely investigated. We evaluated the relationships between white blood cell subtypes, geriatric assessment, depression and frailty syndrome based on the criteria of physical phenotype. In particular, we aimed to analyze by a two-year follow-up and prospective study the predictive value of alterations in WBC, frailty and functional impairment in terms of hospitalizations and all-cause mortality in institutionalized older women. There was a significant and inverse correlation between the frailty score and lymphocyte count at baseline but it did not display any predictive effect for the outcomes (hospitalizations and mortality). In contrast, monocytes count was significantly correlated with number of hospital stays and predicted hospitalizations in the follow-up. High frailty score directly and better functional status (Barthel score) inversely predicted mortality in the follow-up with an HR of 1.87 (95%CI: 1.04–3.35), and 0.97 (95% CI: 0.96–0.99) (p < .05 in both cases). Further investigation into the role of white blood cell subtypes in aging and its associated adverse outcomes in older adults is warranted. Physical phenotype of frailty besides general population, also predicted mortality in older institutionalized women and deserves specific intervention in this subgroup of older individuals.

ACS Style

Julio Fernandez-Garrido; Vicente Ruiz-Ros; Rut Navarro-Martínez; Cristina Buigues; Mary Martínez-Martínez; Yolanda Verdejo; Laura Sanantonio-Camps; Mª. Carmen Mascarós; Omar Cauli. Frailty and leucocyte count are predictors of all-cause mortality and hospitalization length in non-demented institutionalized older women. Experimental Gerontology 2018, 103, 80 -86.

AMA Style

Julio Fernandez-Garrido, Vicente Ruiz-Ros, Rut Navarro-Martínez, Cristina Buigues, Mary Martínez-Martínez, Yolanda Verdejo, Laura Sanantonio-Camps, Mª. Carmen Mascarós, Omar Cauli. Frailty and leucocyte count are predictors of all-cause mortality and hospitalization length in non-demented institutionalized older women. Experimental Gerontology. 2018; 103 ():80-86.

Chicago/Turabian Style

Julio Fernandez-Garrido; Vicente Ruiz-Ros; Rut Navarro-Martínez; Cristina Buigues; Mary Martínez-Martínez; Yolanda Verdejo; Laura Sanantonio-Camps; Mª. Carmen Mascarós; Omar Cauli. 2018. "Frailty and leucocyte count are predictors of all-cause mortality and hospitalization length in non-demented institutionalized older women." Experimental Gerontology 103, no. : 80-86.

Randomized controlled trial
Published: 11 February 2018 in Biological Research For Nursing
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The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices. Methods: This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60–85 years, with no medical history of disease that would preclude them from engaging in physical exercise. Participants were randomly divided into the following groups: elastic tubes with handles group (ETG; n = 22), traditional elastic bands group ( n = 21), and control group (CG; n = 20). Exercise groups (EGs) performed the following supervised RTP: 8 weeks, twice weekly, six overall body exercises, and 3–4 sets of 10 repetitions at a rate of perceived exertion (RPE) of 7–9 on the OMNI-Resistance Exercise Scale of perceived exertion. The controls did not change their usual lifestyle. Outcome measures included body composition (BC; total and regional percentage of fat mass [FM] and fat-free mass [FFM]) and physical performance (PP; dynamic and isometric strength, flexibility, agility/dynamic balance, and endurance). Results: Both EGs exhibited significantly reduced FM in the upper limbs (ULs) and trunk and increased FFM in the UL, while the ETG exhibited a significantly increased trunk FFM. Both EGs improved in PP, and there were no intergroup differences. Trunk FM and FFM and meters walked differed significantly between the ETG and CG. The CG did not exhibit any significant changes. Conclusion: Training with elastic devices at a moderate–high RPE produces short-term improvements in BC and PP in OOW.

ACS Style

Nicole B. Fritz; Álvaro Juesas; Pedro Gargallo; Joaquín Calatayud; Julio Fernandez-Garrido; Michael E. Rogers; Juan C. Colado. Positive Effects of a Short-Term Intense Elastic Resistance Training Program on Body Composition and Physical Functioning in Overweight Older Women. Biological Research For Nursing 2018, 20, 321 -334.

AMA Style

Nicole B. Fritz, Álvaro Juesas, Pedro Gargallo, Joaquín Calatayud, Julio Fernandez-Garrido, Michael E. Rogers, Juan C. Colado. Positive Effects of a Short-Term Intense Elastic Resistance Training Program on Body Composition and Physical Functioning in Overweight Older Women. Biological Research For Nursing. 2018; 20 (3):321-334.

Chicago/Turabian Style

Nicole B. Fritz; Álvaro Juesas; Pedro Gargallo; Joaquín Calatayud; Julio Fernandez-Garrido; Michael E. Rogers; Juan C. Colado. 2018. "Positive Effects of a Short-Term Intense Elastic Resistance Training Program on Body Composition and Physical Functioning in Overweight Older Women." Biological Research For Nursing 20, no. 3: 321-334.

Editorial
Published: 15 February 2017 in Biological Research For Nursing
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Julio Fernández-Garrido; Omar Cauli. Research in Medical–Surgical Nursing. Biological Research For Nursing 2017, 19, 121 -122.

AMA Style

Julio Fernández-Garrido, Omar Cauli. Research in Medical–Surgical Nursing. Biological Research For Nursing. 2017; 19 (2):121-122.

Chicago/Turabian Style

Julio Fernández-Garrido; Omar Cauli. 2017. "Research in Medical–Surgical Nursing." Biological Research For Nursing 19, no. 2: 121-122.

Journal article
Published: 03 January 2017 in Endocrine, Metabolic & Immune Disorders - Drug Targets
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ACS Style

Ana Belen Castello-Domenech; Vanessa Ibáñez Del Valle; Julio Fernandez-Garrido; Mary Martinez-Martinez; Omar Cauli. Sleep Alterations in Non-demented Older Individuals: The Role of Cortisol. Endocrine, Metabolic & Immune Disorders - Drug Targets 2017, 16, 174 -180.

AMA Style

Ana Belen Castello-Domenech, Vanessa Ibáñez Del Valle, Julio Fernandez-Garrido, Mary Martinez-Martinez, Omar Cauli. Sleep Alterations in Non-demented Older Individuals: The Role of Cortisol. Endocrine, Metabolic & Immune Disorders - Drug Targets. 2017; 16 (3):174-180.

Chicago/Turabian Style

Ana Belen Castello-Domenech; Vanessa Ibáñez Del Valle; Julio Fernandez-Garrido; Mary Martinez-Martinez; Omar Cauli. 2017. "Sleep Alterations in Non-demented Older Individuals: The Role of Cortisol." Endocrine, Metabolic & Immune Disorders - Drug Targets 16, no. 3: 174-180.

Comparative study
Published: 01 November 2016 in Biological Research For Nursing
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The aim of this study was to compare the effects of a strength training program (STP) using free weights (FW) versus elastic tubing (ET) in 62 premenopausal, sedentary women diagnosed with metabolic syndrome (MS). Participants were randomly assigned to the FW or ET experimental group (EG) or a control group whose members remained sedentary. Members of each EG followed their assigned STP for 12 weeks, and biomarkers (BMs) related to MS and motor function (MF) parameters were evaluated. Both EGs showed a significant reduction in C-reactive protein level and a positive trend in the other BMs. Almost all MF parameters increased significantly in both EGs. No positive changes were found in the CG. These results indicate that the implementation of an STP, with either FW or ET, improves both metabolic health and MF and should be considered part of the basic approach to health care in women.

ACS Style

Jorge Flandez; Noelia Belando; Pedro Gargallo; Julio Fernández-Garrido; Ronald A. Vargas-Foitzick; Jose Devis-Devis; Juan C. Colado. Metabolic and Functional Profile of Premenopausal Women With Metabolic Syndrome After Training With Elastics as Compared to Free Weights. Biological Research For Nursing 2016, 19, 190 -197.

AMA Style

Jorge Flandez, Noelia Belando, Pedro Gargallo, Julio Fernández-Garrido, Ronald A. Vargas-Foitzick, Jose Devis-Devis, Juan C. Colado. Metabolic and Functional Profile of Premenopausal Women With Metabolic Syndrome After Training With Elastics as Compared to Free Weights. Biological Research For Nursing. 2016; 19 (2):190-197.

Chicago/Turabian Style

Jorge Flandez; Noelia Belando; Pedro Gargallo; Julio Fernández-Garrido; Ronald A. Vargas-Foitzick; Jose Devis-Devis; Juan C. Colado. 2016. "Metabolic and Functional Profile of Premenopausal Women With Metabolic Syndrome After Training With Elastics as Compared to Free Weights." Biological Research For Nursing 19, no. 2: 190-197.

Randomized controlled trial
Published: 14 June 2016 in International Journal of Molecular Sciences
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Aging can result in major changes in the composition and metabolic activities of bacterial populations in the gastrointestinal system and result in impaired function of the immune system. We assessed the efficacy of prebiotic Darmocare Pre® (Bonusan Besloten Vennootschap (BV), Numansdorp, The Netherlands) to evaluate whether the regular intake of this product can improve frailty criteria, functional status and response of the immune system in elderly people affected by the frailty syndrome. The study was a placebo-controlled, randomized, double blind design in sixty older participants aged 65 and over. The prebiotic product was composed of a mixture of inulin plus fructooligosaccharides and was compared with placebo (maltodextrin). Participants were randomized to a parallel group intervention of 13 weeks’ duration with a daily intake of Darmocare Pre® or placebo. Either prebiotic or placebo were administered after breakfast (between 9–10 a.m.) dissolved in a glass of water carefully stirred just before drinking. The primary outcome was to study the effect on frailty syndrome. The secondary outcomes were effect on functional and cognitive behavior and sleep quality. Moreover, we evaluated whether prebiotic administration alters blood parameters (haemogram and biochemical analysis). The overall rate of frailty was not significantly modified by Darmocare Pre® administration. Nevertheless, prebiotic administration compared with placebo significantly improved two frailty criteria, e.g., exhaustion and handgrip strength (p < 0.01 and p < 0.05, respectively). No significant effects were observed in functional and cognitive behavior or sleep quality. The use of novel therapeutic approaches influencing the gut microbiota–muscle–brain axis could be considered for treatment of the frailty syndrome.

ACS Style

Cristina Buigues; Julio Fernández-Garrido; Leo Pruimboom; Aldert J. Hoogland; Rut Navarro-Martínez; Mary Martínez-Martínez; Yolanda Verdejo; Mari Carmen Mascarós; Carlos Peris; Omar Cauli. Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial. International Journal of Molecular Sciences 2016, 17, 932 .

AMA Style

Cristina Buigues, Julio Fernández-Garrido, Leo Pruimboom, Aldert J. Hoogland, Rut Navarro-Martínez, Mary Martínez-Martínez, Yolanda Verdejo, Mari Carmen Mascarós, Carlos Peris, Omar Cauli. Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial. International Journal of Molecular Sciences. 2016; 17 (6):932.

Chicago/Turabian Style

Cristina Buigues; Julio Fernández-Garrido; Leo Pruimboom; Aldert J. Hoogland; Rut Navarro-Martínez; Mary Martínez-Martínez; Yolanda Verdejo; Mari Carmen Mascarós; Carlos Peris; Omar Cauli. 2016. "Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial." International Journal of Molecular Sciences 17, no. 6: 932.

Journal article
Published: 01 May 2016 in Applied Nursing Research
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Serum vitamin D deficiency has been associated with frailty in people aged 65 and over, however its relationship with functional impairment has not been investigated in octogenerian (aged 80-90 years) institutionalized women. We assessed functional impairment in this latter group by measuring frailty syndrome and other geriatric and psychological assessment scales: the Tinetti gait and balance index to determine the risk for falls, the Barthel index to measure the basic activities of daily living, the Lawton index for instrumental activities, the mini-mental score examination test for cognitive impairment, the Yesavage scale for geriatric depression, and the Norton scale for the risk of ulceration. Frail individuals had significantly reduced serum vitamin D concentrations (measured as total 25-hydroxyvitamin D; 25(OH)D) compared to robust individuals, but reduced 25(OH)D concentration did not significantly correlate with frailty syndrome severity, and mean 25(OH)D concentrations were within the recommended levels in all groups. The 25(OH)D concentration did not correlate with any of the blood analytical parameters measured and with the geriatric assessment scales used, suggesting a selective relationship with frailty. These results highlight the need to individualize treatment such as vitamin D supplementation in order to treat frailty syndrome.

ACS Style

Rut Navarro-Martínez; Julio Fernández-Garrido; Cristina Buigues; Mary Martinez-Martinez; Liliana Cantero-Díaz; Yolanda Santamaría-Carrillo; Nuria Serra-Catalá; Carlos Peris; Omar Cauli. Serum vitamin D and functional impairment in octogenarian women. Applied Nursing Research 2016, 30, e10 -e14.

AMA Style

Rut Navarro-Martínez, Julio Fernández-Garrido, Cristina Buigues, Mary Martinez-Martinez, Liliana Cantero-Díaz, Yolanda Santamaría-Carrillo, Nuria Serra-Catalá, Carlos Peris, Omar Cauli. Serum vitamin D and functional impairment in octogenarian women. Applied Nursing Research. 2016; 30 ():e10-e14.

Chicago/Turabian Style

Rut Navarro-Martínez; Julio Fernández-Garrido; Cristina Buigues; Mary Martinez-Martinez; Liliana Cantero-Díaz; Yolanda Santamaría-Carrillo; Nuria Serra-Catalá; Carlos Peris; Omar Cauli. 2016. "Serum vitamin D and functional impairment in octogenarian women." Applied Nursing Research 30, no. : e10-e14.

Multicenter study
Published: 01 December 2015 in Experimental Gerontology
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We used a complete battery of geriatric and psychometric tests to evaluate whether plasma-borne brain-derived neurotrophic factor (BDNF), a master molecule in neuroplasticity, is associated with the severity of functional and cognitive impairment in non-disabled older individuals. There was a significant positive correlation between BDNF plasma concentrations and the Barthel index, a measurement of the ability of individuals to perform the activities of daily living (p = 0.03) and the concentration subcategory measured with the mini mental state examination (MMSE) test (p = 0.01). Furthermore, plasma BDNF inversely and significantly correlated with the blood eosinophil count (p = 0.01), the total cholesterol concentration (p = 0.04), and high-density lipoprotein cholesterol (p = 0.04). However, BDNF did not correlate with any other socio-demographic or clinical characteristics, other analytical parameters measured in the blood, or any other geriatric assessment scales. Our results suggest that BDNF may play a role in the pathophysiology of functional impairment in the elderly and in some aspects of cognitive function. However, more studies are needed to understand the relationship between circulating BDNF and functional impairment to determine if BDNF represents a candidate biomarker for this type of cognitive impairment.

ACS Style

Rut Navarro-Martínez; Julio Fernandez-Garrido; Cristina Buigues; Elena Torralba-Martínez; Mary Martinez-Martinez; Yolanda Verdejo; Mari Carmen Mascarós; Omar Cauli. Brain-derived neurotrophic factor correlates with functional and cognitive impairment in non-disabled older individuals. Experimental Gerontology 2015, 72, 129 -137.

AMA Style

Rut Navarro-Martínez, Julio Fernandez-Garrido, Cristina Buigues, Elena Torralba-Martínez, Mary Martinez-Martinez, Yolanda Verdejo, Mari Carmen Mascarós, Omar Cauli. Brain-derived neurotrophic factor correlates with functional and cognitive impairment in non-disabled older individuals. Experimental Gerontology. 2015; 72 ():129-137.

Chicago/Turabian Style

Rut Navarro-Martínez; Julio Fernandez-Garrido; Cristina Buigues; Elena Torralba-Martínez; Mary Martinez-Martinez; Yolanda Verdejo; Mari Carmen Mascarós; Omar Cauli. 2015. "Brain-derived neurotrophic factor correlates with functional and cognitive impairment in non-disabled older individuals." Experimental Gerontology 72, no. : 129-137.

Journal article
Published: 01 December 2015 in Canadian Journal of Cardiology
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Frailty predicts mortality after acute coronary syndrome (ACS). The standard frailty scales, such as the Fried score, consist of a variety of questionnaires and physical tests. Our aim was to investigate easily available clinical data and blood markers to predict frailty at discharge, in elderly patients after ACS. A total of 342 patients older than 65 years, survivors after ACS, were included. A high number of clinical variables were collected. In addition, blood markers potentially linked to frailty and related to the processes of inflammation, coagulation, hormonal dysregulation, nutrition, renal dysfunction, and heart dysfunction were determined. Frailty was evaluated using the Fried score at discharge. The main outcome was frailty defined by a Fried score ≥ 3 points. Secondary endpoints were mortality and myocardial infarction at 30-month median follow-up. A total of 116 patients were frail. Seven clinical variables or biomarkers predicted frailty: age ≥ 75 years, female, prior ischemic heart disease, admission heart failure, haemoglobin ≤ 12.5 g/dL, vitamin D ≤ 9 ng/mL, and cystatin-C ≥ 1.2 mg/L. This model based on clinical data and biomarkers showed an excellent discrimination accuracy for frailty (C-statistic = 0.818). During the follow-up, 105 patients died and 137 died or suffered myocardial infarction. The clinical data and biomarker model (C-statistics = 0.730 and 0.691) performed better than the Fried score (C-statistics = 0.676 and 0.650) for death and death or myocardial infarction, respectively. Easy available clinical data and biomarkers can identify frail patients at discharge after ACS and predict outcomes better than the standard Fried's frailty scale.

ACS Style

Juan Sanchis; Eduardo Núñez; Vicente Ruiz; Clara Bonanad; Julio Fernandez-Garrido; Omar Cauli; Sergio García-Blas; Luis Mainar; Ernesto Valero; Enrique Rodriguez Borja; Francisco J. Chorro; Carlos Hermenegildo; Julio Núñez. Usefulness of Clinical Data and Biomarkers for the Identification of Frailty After Acute Coronary Syndromes. Canadian Journal of Cardiology 2015, 31, 1462 -1468.

AMA Style

Juan Sanchis, Eduardo Núñez, Vicente Ruiz, Clara Bonanad, Julio Fernandez-Garrido, Omar Cauli, Sergio García-Blas, Luis Mainar, Ernesto Valero, Enrique Rodriguez Borja, Francisco J. Chorro, Carlos Hermenegildo, Julio Núñez. Usefulness of Clinical Data and Biomarkers for the Identification of Frailty After Acute Coronary Syndromes. Canadian Journal of Cardiology. 2015; 31 (12):1462-1468.

Chicago/Turabian Style

Juan Sanchis; Eduardo Núñez; Vicente Ruiz; Clara Bonanad; Julio Fernandez-Garrido; Omar Cauli; Sergio García-Blas; Luis Mainar; Ernesto Valero; Enrique Rodriguez Borja; Francisco J. Chorro; Carlos Hermenegildo; Julio Núñez. 2015. "Usefulness of Clinical Data and Biomarkers for the Identification of Frailty After Acute Coronary Syndromes." Canadian Journal of Cardiology 31, no. 12: 1462-1468.

Review
Published: 01 November 2015 in Archives of Gerontology and Geriatrics
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Frailty is a geriatric syndrome characterized by the clinical presentation of identifiable physical alterations and decreased physiological reserve. The assessment of frailty syndrome has been recently related with post-surgical outcomes and overall mortality in older individuals. We performed searches in Pubmed, Embase, Scopus, SCIELO and IME (Spanish medical index) databases from their start dates to February 2014 for original papers about the identification of the relationship between frailty and pre-operative risk evaluation in people aged 65 and over. We followed criteria of systematic PRISMA guidelines. Two independent reviewers extracted descriptive information on frailty criteria and outcomes from the selected papers: of the 77 articles retrieved from the searches, 32 met the study inclusion criteria. Severity of frailty syndrome significantly correlated with post-surgical mortality rates and with many although not all post-surgical complications. These relationships emerge in different type of surgical procedures and patients' features. The comparison of diagnostic tools to assess frailty in pre-operative risk evaluation are very few and to date, no recommendation can be made about the best scale to measure it. Assessment of frailty syndrome should be added in the pre-operative risk assessment in older individuals.

ACS Style

Cristina Buigues; Pilar Juarros-Folgado; Julio Fernandez-Garrido; Rut Navarro-Martínez; Omar Cauli. Frailty syndrome and pre-operative risk evaluation: A systematic review. Archives of Gerontology and Geriatrics 2015, 61, 309 -321.

AMA Style

Cristina Buigues, Pilar Juarros-Folgado, Julio Fernandez-Garrido, Rut Navarro-Martínez, Omar Cauli. Frailty syndrome and pre-operative risk evaluation: A systematic review. Archives of Gerontology and Geriatrics. 2015; 61 (3):309-321.

Chicago/Turabian Style

Cristina Buigues; Pilar Juarros-Folgado; Julio Fernandez-Garrido; Rut Navarro-Martínez; Omar Cauli. 2015. "Frailty syndrome and pre-operative risk evaluation: A systematic review." Archives of Gerontology and Geriatrics 61, no. 3: 309-321.

Review
Published: 16 October 2014 in Aging & Mental Health
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Objectives: Frailty is a geriatric syndrome characterised by the clinical presentation of identifiable physical alterations such as loss of muscle mass and strength, energy and exercise tolerance, and decreased physiological reserve. Frailty and depressive symptoms are common issues facing older adults and may be associated. It is not clear if the depression facilitates the appearance of frailty syndrome or vice versa or these two coexist independently in the same individuals. Method: We performed searches in several databases (Embase, PubMed, CINAHL, Scopus, and PsycINFO) papers published between November 2003 to February 2014 about frailty syndrome and depression in people aged 65 and older published and the reference lists of from the articles retrieved were pearled in order to identify any which may have been missed in the initial search. Two independent reviewers extracted descriptive information on the prevalence and co-occurrence of frailty and depression in older individuals and of frailty criteria among depressed patients. Results: Depression and frailty occur in a significant proportion of frail older individuals. Common pathophysiological alterations and biomarkers in the two syndromes have been recently described. Conclusion: Studies on the causal relationship between the two syndromes are clearly necessary in the future.

ACS Style

Cristina Buigues; Celia Padilla-Sánchez; Julio Fernandez-Garrido; Rut Navarro-Martínez; Vicente Ruiz-Ros; Omar Cauli. The relationship between depression and frailty syndrome: a systematic review. Aging & Mental Health 2014, 19, 762 -772.

AMA Style

Cristina Buigues, Celia Padilla-Sánchez, Julio Fernandez-Garrido, Rut Navarro-Martínez, Vicente Ruiz-Ros, Omar Cauli. The relationship between depression and frailty syndrome: a systematic review. Aging & Mental Health. 2014; 19 (9):762-772.

Chicago/Turabian Style

Cristina Buigues; Celia Padilla-Sánchez; Julio Fernandez-Garrido; Rut Navarro-Martínez; Vicente Ruiz-Ros; Omar Cauli. 2014. "The relationship between depression and frailty syndrome: a systematic review." Aging & Mental Health 19, no. 9: 762-772.

Review
Published: 01 July 2014 in Archives of Gerontology and Geriatrics
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Frailty is a geriatric syndrome characterized by the clinical presentation of identifiable physical alterations such as loss of muscle mass and strength, energy and exercise tolerance, and decreased physiological reserve. Individuals with one or two of these alterations are defined as prefrail. The clinical features of prefrail older individuals have been investigated to a lesser extent compared to the frail population, even though this intermediate stage may provide insights into the mechanisms involved in the physical decline associated with aging and it is considered to be potentially reversible. We performed searches in the Medline, Embase, Scopus, Cinahl, and Cochrane databases from January 1995 to July 2013 for papers about the identification of prefrail people aged 65 and older published either in English or Spanish, and the reference lists of from the articles retrieved were pearled in order to identify any which may have been missed in the initial search. Two independent reviewers extracted descriptive information on frailty criteria and outcomes from the selected papers: of the 277 articles retrieved from the searches and 25 articles retrieved from pearling, 84 met the study inclusion criteria. The prevalence of prefrailty ranges between 35% and 50% in individuals aged over 60, is more common in women, and the age and the number of comorbidities in these individuals is similar to their frail counterparts. Weakness is the most prevalent symptom in prefrail individuals although there are some sex differences. Some serum biomarkers seem to discriminate prefrail from non-frail individuals but further research would be required to confirm this.

ACS Style

Julio Fernandez-Garrido; Vicente Ruiz-Ros; Cristina Buigues; Rut Navarro-Martinez; Omar Cauli. Clinical features of prefrail older individuals and emerging peripheral biomarkers: A systematic review. Archives of Gerontology and Geriatrics 2014, 59, 7 -17.

AMA Style

Julio Fernandez-Garrido, Vicente Ruiz-Ros, Cristina Buigues, Rut Navarro-Martinez, Omar Cauli. Clinical features of prefrail older individuals and emerging peripheral biomarkers: A systematic review. Archives of Gerontology and Geriatrics. 2014; 59 (1):7-17.

Chicago/Turabian Style

Julio Fernandez-Garrido; Vicente Ruiz-Ros; Cristina Buigues; Rut Navarro-Martinez; Omar Cauli. 2014. "Clinical features of prefrail older individuals and emerging peripheral biomarkers: A systematic review." Archives of Gerontology and Geriatrics 59, no. 1: 7-17.

Journal article
Published: 01 June 2014 in Experimental Gerontology
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Increasing evidence suggests that systemic inflammation is associated with many pathophysiological processes including frailty in older adults. We evaluated the relationships between white blood cell subtypes, geriatric assessment, and frailty syndrome and in particular, how they correlate with individual frailty criteria (involuntary loss of weight, low energy or exhaustion, slow mobility, muscle weakness, and low physical activity) in frail older women. There was a significant and positive correlation between the frailty score and neutrophil count, but a significantly negative correlation was found when this score was compared to the lymphocyte count. These associations were significant only for two frailty criteria: poor muscular strength and low physical activity. Further investigation into the role of white blood cell subtypes in ageing and its associated adverse outcomes in older adults is warranted, in particular in the loss of muscular strength and for poor physical activity.

ACS Style

Julio Fernández-Garrido; Rut Navarro-Martínez; Cristina Buigues-González; Mary Martínez-Martínez; Vicente Ruiz-Ros; Omar Cauli. The value of neutrophil and lymphocyte count in frail older women. Experimental Gerontology 2014, 54, 35 -41.

AMA Style

Julio Fernández-Garrido, Rut Navarro-Martínez, Cristina Buigues-González, Mary Martínez-Martínez, Vicente Ruiz-Ros, Omar Cauli. The value of neutrophil and lymphocyte count in frail older women. Experimental Gerontology. 2014; 54 ():35-41.

Chicago/Turabian Style

Julio Fernández-Garrido; Rut Navarro-Martínez; Cristina Buigues-González; Mary Martínez-Martínez; Vicente Ruiz-Ros; Omar Cauli. 2014. "The value of neutrophil and lymphocyte count in frail older women." Experimental Gerontology 54, no. : 35-41.