Chrysophanol is a unique anthraquinone having broad-spectrum therapeutic potential along with ecological importance. It is the first polyketide that has been reported to be biosynthesized in an organism-specific manner. The traditional Chinese and Korean medicinal systems provide evidence of the beneficial effects of chrysophanol on human health. The global distribution of chrysophanol encountered in two domains of life (bacteria and eukaryota) has motivated researchers to critically evaluate the properties of this compound. A plethora of literature is available on the pharmacological properties of chrysophanol, which include anticancer, hepatoprotective, neuroprotective, anti-inflammatory, antiulcer, and antimicrobial activities. However, the pharmacokinetics and toxicity studies on chrysophanol demand further investigations for it to be used as a drug. This is the first comprehensive review on the natural sources, biosynthetic pathways, and pharmacology of chrysophanol. Here we reviewed recent advancements made on the pharmacokinetics of the chrysophanol. Additionally, we have highlighted the knowledge gaps of its mechanism of action against diseases and toxicity aspects.

Micro- and nanoplastic (MNP) pollution is a significant concern for ecosystems worldwide. The continuous generation and extensive utilization of synthetic plastics have led to the widespread contamination of water and food resources with MNPs. These pollutants originate from daily-use products and industrial waste. Remediation of such pollutants is essential to protect ecosystems and human health since these ubiquitous contaminants pose serious biological and environmental hazards by contaminating food chains, water sources, and the air. Various remediation techniques, including physical, chemical, sophisticated filtration, microbial bioremediation, and adsorption employing novel materials, provide encouraging avenues for tackling this worldwide issue. The biotechnological approaches stand out as effective, eco-friendly, and sustainable solutions for managing these toxic pollutants. However, the complexity of MNP pollution presents significant challenges in its management and regulation. Addressing these challenges requires cross-disciplinary research efforts to develop and implement more efficient, sustainable, eco-friendly, and scalable techniques for mitigating widespread MNP pollution. This review explores the various sources of micro- and nanoplastic contamination in water and food resources, their toxic impacts, remediation strategies—including advanced biotechnological approaches—and the challenges in treating these pollutants to alleviate their effects on ecosystems and human health.

In the present study, zinc oxide nanoparticles (ZnO) were synthesized using cow dung extract to apply sustainable agriculture from rural resources. Studies on their antibacterial potential against E. coli DH 5 alpha indicated lower antimicrobial activities than the bulk Zn and commercial Zn nanoparticles. Compared with control and commercial ZnO nanoparticles, the maximum seed germination, root length, and shoot length were observed after the priming of synthesized ZnO NPs. This study suggests that ZnO may significantly increase seed germination and have lower antimicrobial potential. Further, the lower in-vitro cellular leakage and reactive oxygen species (ROS) production provided new hope for using cow dung extract mediated nanoparticles for agricultural and industrial applications.

Lignocellulose is considered one of the significant recalcitrant materials and also is difficult to break down because of its complex structure. Different microbes such as bacteria and fungi are responsible for breaking down these complex lignin structures. This article discussed briefly the lignin-degrading bacteria and their critical steps involved in lignin depolymerization. In addition, fungi are regarded as the ideal microorganism for the degradation of lignin because of their highly effective hydrolytic and oxidative enzyme systems for the breakdown of lignocellulosic materials. The white rot fungi, mainly belonging to basidiomycetes, is the main degrader of lignin among various microorganisms. This could be achieved because of the presence of lignolytic enzymes such as laccases, lignin peroxidases, and manganese peroxidases. The significance of the fungi and lignolytic enzyme’s role in lignin depolymerization, along with its mechanism and chemical pathways, are emphasized in this article.