Field of scientific interests of Semenov V.E. are synthesis, structure, properties, physiological activity of nitrogen-containing heterocyclic compounds, in particular, the chemistry of pyrimidinophanes - macrocyclic compounds based on nucleotide bases. He made a significant contribution to the development of methods for the synthesis of pyrimidinophanes and multipyrimidinophanes. The prospectivity of the search for antimicrobial agents in a series of macrocyclic derivatives of uracil - pyrimidinophanes is shown, and compounds exhibiting activity at the level of the best standards are obtained. Over the past 5 years, the concept has been substantiated and based on it, compounds have been found i.e. pyrimidine derivatives that stimulate physical performance and exhibit hepato- and neuroprotective properties; among uracil derivatives, macrocyclic human acetylcholinesterase inhibitors were found that inhibit the enzyme in nanomolar concentrations and can be used as medications for treating syndromes of pathological muscle weakness; new classes of substances have been created on the basis of uracil derivatives, i.e. selective inhibitors of human acetylcholinesterase capable of stopping the symptoms of neurodegenerative , in particular Alzheimer's disease, as well as reactivants of cholinesterase blocked by organophosphorus compounds.