Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide. Intestinal cells are CYP27B1 gene expression sites and, as a consequence, they are capable of converting pro-vitamin D into the active paracrine and autocrine forms. It was demonstrated that rs10877012 polymorphism in the CYP27B1 gene influenced the circulating vitamin D level. This provided a rationale for determining the role that this polymorphism plays in the risk of developing colon cancer. In this study, we investigated the association of rs10877012 (T/G) polymorphism in the CYP27B1 gene with CRC susceptibility. The study population (n = 325) included CRC patients (n = 106) and healthy controls (n = 219). DNA was extracted from peripheral leukocytes and analyzed for the CYP27B1 polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We found an association between the presence of the T allele at the polymorphic site (odds ratio (OR) = 2.94; 95% CI 1.77–4.86; p < 0.0001) and a decreased CRC incidence.

Anal condylomata acuminata was a well-known disease in ancient times but in recent years there has been a rapidly increasing number of people who suffer from this disease. The main cause of this disease is infection of human papilloma virus (HPV) which occurs through sexual contact. Currently there are three different ways to treat anal condylomata. Small changes of anal condylomata can be treated with local therapeutic agents, but the best results of treatment of extensive changes are obtained by surgical techniques. The study group consisted of 30 patients with diagnosed extensive anal condylomata who underwent surgery in Mikolaj Pirogow High Specialized Hospital in Lodz. The survey was conducted from 2007 to 2011. Patients had been directed to the surgical ward by general surgeons and practitioners, proctologists and urologists. The diagnosis was made after proctological assessment in the knee-chest position. All patients underwent surgery and had complete macroscopic electroexcision of anal condylomata. In the research group there was no mortality. Postoperative complications occurred in 4 (13.3%) patients--postoperative bleeding. Strong pain was present in 14 (46.7%) patients but only in the postoperative period. During postoperative follow-up there was no observed infection in the anal region or recurrence of disease. In the operated group there were no observed cosmetic deformations of the anus and/or the anal canal, narrow anal canal or functional fecal incontinence symptoms. Surgical treatment of anal condylomata is an effective and safe method for the patient. In our research there were no serious postoperative complications or recurrence of the disease during the follow-up period.

Absztrakt: A vékonybél daganatai ritkák, az egész béltraktus daganatainak 1–5%-át képezik. A vékonybél leggyakoribb malignus daganatai az adenocarcinoma, lymphoma és a neuroendokrin tumorok. Ritkábban előforduló daganatok közé tartoznak a gastrointestinalis stromalis tumorok (GIST), a leiomyosarcoma és a leiomyoma. A leiomyoma leggyakrabban a jejunumban fordul elő, ezt követi az ileum és a duodenum. A legtöbb esetben ezen tumorok diagnózisát műtét előtt nagyon nehéz felállítani. A műtéti kezelés lehetőségei duodenalis tumorok esetén lokális excisio, szegmentális duodenumreszekció és pancreaticoduodenectomia. Ezen jól differenciált tumorok prognózisa relatíve jó. A szerzők egy 61 éves férfi esetét tárgyalják, aki duodenalis tumor miatt került felvételre. Panaszai három hónappal felvétele előtt kezdődtek, amelyek periodikusan jelentkező epigastrialis tompa fájdalom és hányás volt. A benignus duodenalis tumor excisiójára került sor, és a beteg a műtétet követő hetedik napon hagyta el a kórházat panaszmentesen. A szerzők a duodenalis leiomyomáról közölt irodalmi adatokat is áttekintik.