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André Marette
Department of Medicine, Québec Heart and Lung Institute, Université Laval, Québec, QC G1V 4G5, Canada

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Journal article
Published: 31 August 2021 in Foods
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Over the past years, promising results from studies have shown that herring milt hydrolysates (HMH) can counter immune-metabolic disorders associated with obesity. However, more studies must corroborate these results. Thus, three commercial hydrolysates (HMH1, HMH2, and HMH3) as well as the fractions of two of them (HMH4 and HMH5) obtained by electrodialysis with ultrafiltration membranes (EDUF) were evaluated in vivo at higher doses compared to a previous study. To achieve this, seven groups of mice were fed for 8 weeks with either a control Chow diet or an obesogenic diet rich in fat and sucrose (HFHS) and supplemented by daily gavage with water or 312.5 mg/kg of one of the five HMH products. In summary, HMH supplements had no impact on weight gain. In the insulin tolerance test (ITT), HMH2 and its HMH5 fraction significantly reduced the blood sugar variation (p< 0.05). However, during the glucose tolerance (OGTT), HMH2 supplement increased the hyperinsulinemia variation (p< 0.05) induced by the HFHS diet. HMH1, HMH2, and HMH5 supplements generated potentially beneficial changes for health in the gut microbiota. These results reveal that HMH do not counteract obesity effects but may decrease certain physiological effects induced by obesity.

ACS Style

Noémie Benoit; Marie-Julie Dubois; Geneviève Pilon; Thibault V. Varin; André Marette; Laurent Bazinet. Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model. Foods 2021, 10, 2046 .

AMA Style

Noémie Benoit, Marie-Julie Dubois, Geneviève Pilon, Thibault V. Varin, André Marette, Laurent Bazinet. Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model. Foods. 2021; 10 (9):2046.

Chicago/Turabian Style

Noémie Benoit; Marie-Julie Dubois; Geneviève Pilon; Thibault V. Varin; André Marette; Laurent Bazinet. 2021. "Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model." Foods 10, no. 9: 2046.

Original article
Published: 27 August 2021 in Obesity
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Objective This study investigated the effects of a low-dose salmon peptide fraction (SPF) and vitamin D3 (VitD3) in obese and VitD3-deficient mice at risk of metabolic syndrome (MetS). Methods Obese and VitD3-deficient low-density lipoprotein receptor (LDLr)−/−/apolipoprotein B100 (ApoB)100/100 mice were treated with high-fat high-sucrose diets, with 25% of dietary proteins replaced by SPF or a nonfish protein mix (MP). The SPF and MP groups received a VitD3-deficient diet or a supplementation of 15,000 IU of VitD3 per kilogram of diet. Glucose homeostasis, atherosclerosis, nonalcoholic fatty liver disease, and gut health were assessed. Results VitD3 supplementation increased plasma 25-hydroxyvitamin D to optimal status whereas the VitD3-deficient diet maintained moderate deficiency. SPF-treated groups spent more energy and accumulated less visceral fat in association with an improved adipokine profile. SPF lowered homeostatic model assessment of insulin resistance compared with MP, suggesting that SPF can improve insulin sensitivity. SPF alone blunted hepatic and colonic inflammation, whereas VitD3 supplementation attenuated ileal inflammation. These effects were associated with changes in gut microbiota such as increased Mogibacterium and Muribaculaceae. Conclusions SPF treatment improves MetS by modulating hepatic and gut inflammation along with gut microbiota, suggesting that SPF operates through a gut-liver axis. VitD3 supplementation has limited influence on MetS in this model.

ACS Style

Marion Valle; Patricia L. Mitchell; Geneviève Pilon; Thibault Varin; Loïc Hénault; Jonathan Rolin; Roger McLeod; Tom Gill; Denis Richard; Marie‐Claude Vohl; Hélène Jacques; Claudia Gagnon; Laurent Bazinet; André Marette. Salmon peptides limit obesity‐associated metabolic disorders by modulating a gut‐liver axis in vitamin D‐deficient mice. Obesity 2021, 1 .

AMA Style

Marion Valle, Patricia L. Mitchell, Geneviève Pilon, Thibault Varin, Loïc Hénault, Jonathan Rolin, Roger McLeod, Tom Gill, Denis Richard, Marie‐Claude Vohl, Hélène Jacques, Claudia Gagnon, Laurent Bazinet, André Marette. Salmon peptides limit obesity‐associated metabolic disorders by modulating a gut‐liver axis in vitamin D‐deficient mice. Obesity. 2021; ():1.

Chicago/Turabian Style

Marion Valle; Patricia L. Mitchell; Geneviève Pilon; Thibault Varin; Loïc Hénault; Jonathan Rolin; Roger McLeod; Tom Gill; Denis Richard; Marie‐Claude Vohl; Hélène Jacques; Claudia Gagnon; Laurent Bazinet; André Marette. 2021. "Salmon peptides limit obesity‐associated metabolic disorders by modulating a gut‐liver axis in vitamin D‐deficient mice." Obesity , no. : 1.

Journal article
Published: 23 July 2021 in Membranes
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Electrodialysis with ultrafiltration membrane (EDUF) was selected to separate a herring milt hydrolysate (HMH) in a scale-up and long-term study for the recovery of bioactive peptides. The scale-up was performed to maximise peptide recovery by placing a total membrane area of 0.08 m2 for each anionic and cationic compartment. Twelve consecutive runs were carried out, for a total of 69 h, with minimal salt solution cleaning in between experiments. The final peptide migration rate showed that cationic peptides had a higher average migration rate (5.2 ± 0.8 g/m2·h), compared to anionic peptides (4.7 ± 1.1 g/m2·h). Migration was also selective according to peptide identifications and molecular mass distribution where only small molecular weights were found (<1000 Da) in both recovery compartments. The areal system resistance slightly decreased during each run and the averaged values were stable in between experiments since they were all found in the 95% confidence interval. In addition, total relative energy consumption was quite consistent with an average value of 39.95 ± 6.47 Wh/g all along the 12 consecutive runs. Finally, according to membrane characterization, there was no visual fouling on the different membranes present in the EDUF cell after 69 h of treatment. This may be due to the salt cleaning in between experiments which allowed removal of peptides from the membranes, thus allowing recovering initial system working parameters at the beginning of each run. The entire process was revealed to be very consistent and repeatable in terms of peptide migration, global system resistance, and energy consumption. To the best of our knowledge, this is the first time such EDUF conditions (membrane surface, duration, and minimal salt cleaning between experiments) are being tested on a complex hydrolysate.

ACS Style

Jacinthe Thibodeau; Noémie Benoit; Véronique Perreault; Laurent Bazinet. Scale-Up and Long-Term Study of Electrodialysis with Ultrafiltration Membrane for the Separation of a Herring Milt Hydrolysate. Membranes 2021, 11, 558 .

AMA Style

Jacinthe Thibodeau, Noémie Benoit, Véronique Perreault, Laurent Bazinet. Scale-Up and Long-Term Study of Electrodialysis with Ultrafiltration Membrane for the Separation of a Herring Milt Hydrolysate. Membranes. 2021; 11 (8):558.

Chicago/Turabian Style

Jacinthe Thibodeau; Noémie Benoit; Véronique Perreault; Laurent Bazinet. 2021. "Scale-Up and Long-Term Study of Electrodialysis with Ultrafiltration Membrane for the Separation of a Herring Milt Hydrolysate." Membranes 11, no. 8: 558.

Journal article
Published: 15 July 2021 in Foods
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Cranberry (Vaccinium macrocarpon) may be a potent natural adjuvant for the prevention of oral diseases due to its anti-adherence, anti-cariogenic, and anti-inflammatory properties. However, the high titrable acidity of cranberry juice (CJ) has been reported to cause gastrointestinal discomfort, leading consumers to restrict their intake of this beverage. Electrodialysis with a bipolar membrane (EDBM) can reduce the organic acid content of CJ while retaining the flavonoids associated with potential health benefits. This study aimed to assess how the deacidification of CJ by EDBM impacts the antibacterial properties of the beverage against cariogenic (Streptococcus mutans, Streptococcus sobrinus) and commensal (Streptococcus gordonii, Streptococcus oralis, Streptococcus salivarius) streptococci, and how it affects oral epithelial barrier function and inflammatory response in an in vitro model. The removal of organic acids from CJ (deacidification rate ≥42%) reduced the bactericidal activity of the beverage against planktonic S. mutans and S. gordonii after a 15-min exposure, whereas only the viability of S. gordonii was significantly impacted by CJ deacidification rate when the bacteria were embedded in a biofilm. Moreover, conditioning saliva-coated hydroxyapatite with undiluted CJ samples significantly lowered the adherence of S. mutans, S. sobrinus, and S. oralis. With respect to epithelial barrier function, exposure to CJ deacidified at a rate of ≥19% maintained the integrity of a keratinocyte monolayer over the course of 24 h compared to raw CJ, as assessed by the determination of transepithelial electrical resistance (TER) and fluorescein isothiocyanate-conjugated dextran paracellular transport. These results can be in part attributed to the inability of the deacidified CJ to disrupt two tight junction proteins, zonula occludens−1 and occludin, following exposure, unlike raw CJ. Deacidification of CJ impacted the secretion of IL-6, but not of IL-8, by oral epithelial cells. In conclusion, deacidification of CJ appears to provide benefits with respect to the maintenance of oral health.

ACS Style

Geneviève Pellerin; Laurent Bazinet; Daniel Grenier. Deacidification of Cranberry Juice Reduces Its Antibacterial Properties against Oral Streptococci but Preserves Barrier Function and Attenuates the Inflammatory Response of Oral Epithelial Cells. Foods 2021, 10, 1634 .

AMA Style

Geneviève Pellerin, Laurent Bazinet, Daniel Grenier. Deacidification of Cranberry Juice Reduces Its Antibacterial Properties against Oral Streptococci but Preserves Barrier Function and Attenuates the Inflammatory Response of Oral Epithelial Cells. Foods. 2021; 10 (7):1634.

Chicago/Turabian Style

Geneviève Pellerin; Laurent Bazinet; Daniel Grenier. 2021. "Deacidification of Cranberry Juice Reduces Its Antibacterial Properties against Oral Streptococci but Preserves Barrier Function and Attenuates the Inflammatory Response of Oral Epithelial Cells." Foods 10, no. 7: 1634.

Journal article
Published: 15 July 2021 in Membranes
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The efficiency of separation processes using ion exchange membranes (IEMs), especially in the food industry, is significantly limited by the fouling phenomenon, which is the process of the attachment and growth of certain species on the surface and inside the membrane. Pulsed electric field (PEF) mode, which consists in the application of constant current density pulses during a fixed time (Ton) alternated with pause lapses (Toff), has a positive antifouling impact. The aim of this study was to investigate the combined effect of three different relatively high flow rates of feed solution (corresponding to Reynolds numbers of 187, 374 and 560) and various pulse–pause ratios of PEF current regime on protein fouling kinetics during electrodialysis with bipolar membranes (EDBM) of a model caseinate solution. Four different pulse/pause regimes (with Ton/Toff ratios equal to 10 s/10 s, 10 s/20 s, 10 s/33 s and 10 s/50 s) during electrodialysis (ED) treatment were evaluated at a current density of 5 mA/cm2. It was found that increasing the pause duration and caseinate solution flow rate had a positive impact on the minimization of protein fouling occurring on the cationic surface of the bipolar membrane (BPM) during the EDBM. Both a long pause and high flow rate contribute to a more effective decrease in the concentration of protons and caseinate anions at the BPM surface: a very good membrane performance was achieved with 50 s of pause duration of PEF and a flow rate corresponding to Re = 374. A further increase in PEF pause duration (above 50 s) or flow rate (above Re = 374) did not lead to a significant decrease in the amount of fouling.

ACS Style

Vladlen Nichka; Victor Nikonenko; Laurent Bazinet. Fouling Mitigation by Optimizing Flow Rate and Pulsed Electric Field during Bipolar Membrane Electroacidification of Caseinate Solution. Membranes 2021, 11, 534 .

AMA Style

Vladlen Nichka, Victor Nikonenko, Laurent Bazinet. Fouling Mitigation by Optimizing Flow Rate and Pulsed Electric Field during Bipolar Membrane Electroacidification of Caseinate Solution. Membranes. 2021; 11 (7):534.

Chicago/Turabian Style

Vladlen Nichka; Victor Nikonenko; Laurent Bazinet. 2021. "Fouling Mitigation by Optimizing Flow Rate and Pulsed Electric Field during Bipolar Membrane Electroacidification of Caseinate Solution." Membranes 11, no. 7: 534.

Journal article
Published: 14 July 2021 in Membranes
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Natural bioactive peptides are suitable candidates for preventing the development of Type 2 diabetes (T2D), by reducing the various risk factors. The aim of this study was to concentrate glucoregulatory and anti-inflammatory peptides, from salmon by-products, by electrodialysis with ultrafiltration membrane (EDUF), and to identify peptides responsible for these bioactivities. Two EDUF configurations (1 and 2) were used to concentrate anionic and cationic peptides, respectively. After EDUF separation, two fractions demonstrated interesting properties: the initial fraction of the EDUF configuration 1 and the final fraction of the EDUF configuration 2 both showed biological activities to (1) increase glucose uptake in L6 muscle cells in insulin condition at 1 ng/mL (by 12% and 21%, respectively), (2) decrease hepatic glucose production in hepatic cells at 1 ng/mL in basal (17% and 16%, respectively), and insulin (25% and 34%, respectively) conditions, and (3) decrease LPS-induced inflammation in macrophages at 1 g/mL (45% and 30%, respectively). More impressive, the initial fraction of the EDUF configuration 1 (45% reduction) showed the same effect as the phenformin at 10 μM (40%), a drug used to treat T2D. Thirteen peptides were identified, chemically synthesized, and tested in-vitro for these three bioactivities. Thus, four new bioactive peptides were identified: IPVE increased glucose uptake by muscle cells, IVDI and IEGTL decreased hepatic glucose production (HGP) of insulin, whereas VAPEEHPTL decreased HGP under both basal condition and in the presence of insulin. To the best of our knowledge, this is the first time that (1) bioactive peptide fractions generated after separation by EDUF were demonstrated to be bioactive on three different criteria; all involved in the T2D, and (2) potential sequences involved in the improvement of glucose uptake and/or in the regulation of HGP were identified from a salmon protein hydrolysate.

ACS Style

Loïc Henaux; Karina Pereira; Jacinthe Thibodeau; Geneviève Pilon; Tom Gill; André Marette; Laurent Bazinet. Glucoregulatory and Anti-Inflammatory Activities of Peptide Fractions Separated by Electrodialysis with Ultrafiltration Membranes from Salmon Protein Hydrolysate and Identification of Four Novel Glucoregulatory Peptides. Membranes 2021, 11, 528 .

AMA Style

Loïc Henaux, Karina Pereira, Jacinthe Thibodeau, Geneviève Pilon, Tom Gill, André Marette, Laurent Bazinet. Glucoregulatory and Anti-Inflammatory Activities of Peptide Fractions Separated by Electrodialysis with Ultrafiltration Membranes from Salmon Protein Hydrolysate and Identification of Four Novel Glucoregulatory Peptides. Membranes. 2021; 11 (7):528.

Chicago/Turabian Style

Loïc Henaux; Karina Pereira; Jacinthe Thibodeau; Geneviève Pilon; Tom Gill; André Marette; Laurent Bazinet. 2021. "Glucoregulatory and Anti-Inflammatory Activities of Peptide Fractions Separated by Electrodialysis with Ultrafiltration Membranes from Salmon Protein Hydrolysate and Identification of Four Novel Glucoregulatory Peptides." Membranes 11, no. 7: 528.

Editorial
Published: 29 June 2021 in Membranes
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Population growth and urbanization present serious challenges for the biofood sectors since there will be a 70% increase in the global demand by 2050

ACS Style

Laurent Bazinet. Special Issue “Membrane Technologies for Sustainable Biofood Production Lines”. Membranes 2021, 11, 485 .

AMA Style

Laurent Bazinet. Special Issue “Membrane Technologies for Sustainable Biofood Production Lines”. Membranes. 2021; 11 (7):485.

Chicago/Turabian Style

Laurent Bazinet. 2021. "Special Issue “Membrane Technologies for Sustainable Biofood Production Lines”." Membranes 11, no. 7: 485.

Journal article
Published: 19 June 2021 in Future Foods
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Electrodialysis with bipolar membrane (EDBM) is promising to recover phospholipids (PLs) from sweet whey and whey protein concentrate (WPC), as it promotes lipoprotein complex formation following a decrease in pH and ionic strength. The aim of this work was to study the impact of dilution factor (without dilution, with a 2X-4X-6X dilution) after EDBM on the process performances. For both products, a 4X dilution, which corresponds to a decrease in ionic strength of 81.4±1.5 % for sweet whey and 79.4±0.4 % for WPC, seemed sufficient to maximize lipoprotein complex formation as a plateau was reached in the defatting rates. Furthermore, it was demonstrated that the process could be used to recover PLs. Higher PL contents were found in the precipitates recovered from sweet whey combined with a dilution: highest contents in total PLs for WPC (7.45±0.49 and 8.00±0.49g/100g with a 4X-6X dilution) were not different from the lowest content for sweet whey (7.50±1.18g/100g without dilution). For both products, the main PLs recovered were phosphatidylethanolamine and phosphatidylserine, which respectively represented between 42.0±1.7 to 51.6±2.3 % and 30.1±2.2 to 38.7±0.8 % of total PLs. Furthermore, considering their high ecoefficiency scores, sweet whey combined with a 2X or 4X dilution are the most promising conditions.

ACS Style

Mélanie Faucher; Véronique Perreault; Ozan Nazim Ciftci; Sami Gaaloul; Laurent Bazinet. Phospholipid recovery from sweet whey and whey protein concentrate: Use of electrodialysis with bipolar membrane combined with a dilution factor as an ecoefficient method. Future Foods 2021, 100052 .

AMA Style

Mélanie Faucher, Véronique Perreault, Ozan Nazim Ciftci, Sami Gaaloul, Laurent Bazinet. Phospholipid recovery from sweet whey and whey protein concentrate: Use of electrodialysis with bipolar membrane combined with a dilution factor as an ecoefficient method. Future Foods. 2021; ():100052.

Chicago/Turabian Style

Mélanie Faucher; Véronique Perreault; Ozan Nazim Ciftci; Sami Gaaloul; Laurent Bazinet. 2021. "Phospholipid recovery from sweet whey and whey protein concentrate: Use of electrodialysis with bipolar membrane combined with a dilution factor as an ecoefficient method." Future Foods , no. : 100052.

Journal article
Published: 07 June 2021 in Nature Communications
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Animal models of human diseases are classically fed purified diets that contain casein as the unique protein source. We show that provision of a mixed protein source mirroring that found in the western diet exacerbates diet-induced obesity and insulin resistance by potentiating hepatic mTORC1/S6K1 signaling as compared to casein alone. These effects involve alterations in gut microbiota as shown by fecal microbiota transplantation studies. The detrimental impact of the mixed protein source is also linked with early changes in microbial production of branched-chain fatty acids (BCFA) and elevated plasma and hepatic acylcarnitines, indicative of aberrant mitochondrial fatty acid oxidation. We further show that the BCFA, isobutyric and isovaleric acid, increase glucose production and activate mTORC1/S6K1 in hepatocytes. Our findings demonstrate that alteration of dietary protein source exerts a rapid and robust impact on gut microbiota and BCFA with significant consequences for the development of obesity and insulin resistance.

ACS Style

Béatrice S.-Y. Choi; Noëmie Daniel; Vanessa P. Houde; Adia Ouellette; Bruno Marcotte; Thibault V. Varin; Cécile Vors; Perrine Feutry; Olga Ilkayeva; Marcus Ståhlman; Philippe St-Pierre; Fredrik Bäckhed; Angelo Tremblay; Phillip J. White; André Marette. Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice. Nature Communications 2021, 12, 1 -16.

AMA Style

Béatrice S.-Y. Choi, Noëmie Daniel, Vanessa P. Houde, Adia Ouellette, Bruno Marcotte, Thibault V. Varin, Cécile Vors, Perrine Feutry, Olga Ilkayeva, Marcus Ståhlman, Philippe St-Pierre, Fredrik Bäckhed, Angelo Tremblay, Phillip J. White, André Marette. Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice. Nature Communications. 2021; 12 (1):1-16.

Chicago/Turabian Style

Béatrice S.-Y. Choi; Noëmie Daniel; Vanessa P. Houde; Adia Ouellette; Bruno Marcotte; Thibault V. Varin; Cécile Vors; Perrine Feutry; Olga Ilkayeva; Marcus Ståhlman; Philippe St-Pierre; Fredrik Bäckhed; Angelo Tremblay; Phillip J. White; André Marette. 2021. "Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice." Nature Communications 12, no. 1: 1-16.

Journal article
Published: 17 April 2021 in Separation and Purification Technology
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Production of bioactive peptides from slaughterhouse wastes with a final low salt content by electrodialysis with bipolar membranes (EDBM) has recently been demonstrated as an innovative and efficient technology. However, a limitation in the electro-acidification process was noticed due to membrane fouling. In this context, the aim of the present work was to identify process conditions that could reduce peptide fouling in EDBM. Hence, two different conductivity levels (0.9 mS/cm and 4.5 mS/cm) were investigated in bipolar/monopolar (anionic and cationic) configuration and compared to conventional hydrolysis in the same conductivity conditions as well as a conventional hydrolysis using a buffer solution. The impact of such conductivity levels was studied during EDBM especially on membrane fouling and hydrolysis parameters: 1) kinetics of the enzymatic mechanism, 2) degree of hydrolysis and 3) peptide population. The results showed the same enzymatic mechanism “one-by-one” for all the conditions but a slower enzymatic kinetics for EDBM-0.9 mS/cm. EDBM-0.9 mS/cm allowed the production of bioactive peptides but with fouling formation on MCP while EDBM-4.5 mS/cm allowed the production of bioactive peptides without any fouling. Finally, optimizing certain conditions for further studies would lead to a promising green process to substitute synthetic additives used to protect food by antimicrobial peptides from blood slaughterhouses.

ACS Style

Mira Abou-Diab; Jacinthe Thibodeau; Ismail Fliss; Pascal Dhulster; Naima Nedjar; Laurent Bazinet. Impact of conductivity on the performances of electro-acidification and enzymatic hydrolysis phases of bovine hemoglobin by electrodialysis with bipolar membranes for the production of bioactive peptides. Separation and Purification Technology 2021, 269, 118650 .

AMA Style

Mira Abou-Diab, Jacinthe Thibodeau, Ismail Fliss, Pascal Dhulster, Naima Nedjar, Laurent Bazinet. Impact of conductivity on the performances of electro-acidification and enzymatic hydrolysis phases of bovine hemoglobin by electrodialysis with bipolar membranes for the production of bioactive peptides. Separation and Purification Technology. 2021; 269 ():118650.

Chicago/Turabian Style

Mira Abou-Diab; Jacinthe Thibodeau; Ismail Fliss; Pascal Dhulster; Naima Nedjar; Laurent Bazinet. 2021. "Impact of conductivity on the performances of electro-acidification and enzymatic hydrolysis phases of bovine hemoglobin by electrodialysis with bipolar membranes for the production of bioactive peptides." Separation and Purification Technology 269, no. : 118650.

Journal article
Published: 17 April 2021 in Foods
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Herring milt hydrolysate (HMH) presents the disadvantage of being associated with an unpleasant smell limiting its use. Thus, to develop a new effective and easy-to-use deodorization method, this research aimed to deepen the knowledge regarding the impacts of pH (pH 7 vs. pH 10), overnight stirring with nitrogen (+N vs. −N) and deaerator treatment (+D vs. −D) on the odorous content of HMH. This latter included dimethylamine (DMA), trimethylamine (TMA), trimethylamine oxide (TMAO) and the most potent odor-active compounds of HMH. Results showed that pH had a huge impact on the targeted compounds resulting in higher detected concentrations of DMA, TMA and TMAO at pH 10 than at pH 7 (p < 0.05) while the opposite trend was observed for the most potent odor-active compounds of HMH (p < 0.05). Moreover, independently of the pH condition, the overnight stirring with or without nitrogen had no impact (p > 0.05). Finally, the deaerator treatment was more effective to remove TMA and DMA at pH 10 than at pH 7 (p < 0.05) while the opposite trend was observed for the most potent odor-active compounds (p < 0.05). Sensory analysis confirmed that the application of pH 10 −N +D and pH 7 −N +D + alkalization pH 10 conditions led to the least odorous products (p < 0.05).

ACS Style

Sarah Todeschini; Véronique Perreault; Charles Goulet; Mélanie Bouchard; Pascal Dubé; Yvan Boutin; Laurent Bazinet. Development of a New Deodorization Method of Herring Milt Hydrolysate: Impacts of pH, Stirring with Nitrogen and Deaerator Treatment on the Odorous Content. Foods 2021, 10, 884 .

AMA Style

Sarah Todeschini, Véronique Perreault, Charles Goulet, Mélanie Bouchard, Pascal Dubé, Yvan Boutin, Laurent Bazinet. Development of a New Deodorization Method of Herring Milt Hydrolysate: Impacts of pH, Stirring with Nitrogen and Deaerator Treatment on the Odorous Content. Foods. 2021; 10 (4):884.

Chicago/Turabian Style

Sarah Todeschini; Véronique Perreault; Charles Goulet; Mélanie Bouchard; Pascal Dubé; Yvan Boutin; Laurent Bazinet. 2021. "Development of a New Deodorization Method of Herring Milt Hydrolysate: Impacts of pH, Stirring with Nitrogen and Deaerator Treatment on the Odorous Content." Foods 10, no. 4: 884.

Research article
Published: 09 April 2021 in The FASEB Journal
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Diabetic nephropathy (DN) remains the major cause of end‐stage renal disease (ESRD). We used high‐fat/high‐sucrose (HFHS)‐fed LDLr‐/‐/ApoB100/100 mice with transgenic overexpression of IGFII in pancreatic β‐cells (LRKOB100/IGFII) as a model of ESRD to test whether dietary long chain omega‐3 polyunsaturated fatty acids LCω3FA‐rich fish oil (FO) could prevent ESRD development. We further evaluated the potential of docosahexaenoic acid (DHA)‐derived pro‐resolving lipid mediators, 17‐hydroxy‐DHA (17‐HDHA) and Protectin DX (PDX), to reverse established ESRD damage. HFHS‐fed vehicle‐treated LRKOB100/IGFII mice developed severe kidney dysfunction leading to ESRD, as revealed by advanced glomerular fibrosis and mesangial expansion along with reduced percent survival. The kidney failure outcome was associated with cardiac dysfunction, revealed by reduced heart rate and prolonged diastolic and systolic time. Dietary FO prevented kidney damage, lean mass loss, cardiac dysfunction, and death. 17‐HDHA reduced podocyte foot process effacement while PDX treatment alleviated kidney fibrosis and mesangial expansion as compared to vehicle treatment. Only PDX therapy was effective at preserving the heart function and survival rate. These results show that dietary LCω3FA intake can prevent ESRD and cardiac dysfunction in LRKOB100/IGFII diabetic mice. Our data further reveals that PDX can protect against renal failure and cardiac dysfunction, offering a potential new therapeutic strategy against ESRD.

ACS Style

Laís R. Perazza; Patricia L. Mitchell; Farah Lizotte; Benjamin A. H. Jensen; Philippe St‐Pierre; Jocelyn Trottier; Olivier Barbier; Patrick Mathieu; Pedro M. Geraldes; André Marette. Fish oil replacement prevents, while docosahexaenoic acid‐derived protectin DX mitigates end‐stage‐renal‐disease in atherosclerotic diabetic mice. The FASEB Journal 2021, 35, e21559 .

AMA Style

Laís R. Perazza, Patricia L. Mitchell, Farah Lizotte, Benjamin A. H. Jensen, Philippe St‐Pierre, Jocelyn Trottier, Olivier Barbier, Patrick Mathieu, Pedro M. Geraldes, André Marette. Fish oil replacement prevents, while docosahexaenoic acid‐derived protectin DX mitigates end‐stage‐renal‐disease in atherosclerotic diabetic mice. The FASEB Journal. 2021; 35 (5):e21559.

Chicago/Turabian Style

Laís R. Perazza; Patricia L. Mitchell; Farah Lizotte; Benjamin A. H. Jensen; Philippe St‐Pierre; Jocelyn Trottier; Olivier Barbier; Patrick Mathieu; Pedro M. Geraldes; André Marette. 2021. "Fish oil replacement prevents, while docosahexaenoic acid‐derived protectin DX mitigates end‐stage‐renal‐disease in atherosclerotic diabetic mice." The FASEB Journal 35, no. 5: e21559.

Correspondence
Published: 05 April 2021 in Atherosclerosis
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ACS Style

Laís R. Perazza; Noëmie Daniel; Patricia L. Mitchell; Benjamin A.H. Jensen; André Marette. Reply to: “Dietary sucrose induces atherosclerotic diseases more than dietary fat in LDLr−/− ApoB mice: Is it independent of differences in plasma cholesterol levels?”. Atherosclerosis 2021, 325, 118 -120.

AMA Style

Laís R. Perazza, Noëmie Daniel, Patricia L. Mitchell, Benjamin A.H. Jensen, André Marette. Reply to: “Dietary sucrose induces atherosclerotic diseases more than dietary fat in LDLr−/− ApoB mice: Is it independent of differences in plasma cholesterol levels?”. Atherosclerosis. 2021; 325 ():118-120.

Chicago/Turabian Style

Laís R. Perazza; Noëmie Daniel; Patricia L. Mitchell; Benjamin A.H. Jensen; André Marette. 2021. "Reply to: “Dietary sucrose induces atherosclerotic diseases more than dietary fat in LDLr−/− ApoB mice: Is it independent of differences in plasma cholesterol levels?”." Atherosclerosis 325, no. : 118-120.

Journal article
Published: 05 April 2021 in Membranes
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Despite the tremendous success of the application of anion exchange resins (IX) in natural organic matter (NOM) removal over conventional removal methods, the considerable amount of brine spent during its regeneration cycle makes its sustainability questionable. This polluting saline stream can be challenging to manage and costly to discharge. Alternatively, and with the recent shift in perception of resource recovery, the produced spent brine can no longer be seen as a polluting waste but as an unconventional source of water, minerals and nutrients. In this research, for the first time, we evaluated the effectiveness of an integrated monovalent selective electrodialysis (MSED) and direct contact membrane distillation (DCMD) system in IX spent brine desalination and resource recovery. Of particular interest were the effects of operating time on the characteristics of the monovalent permselective ion exchange membranes, the impact of the DCMD stack configuration on minimizing heat loss to the ambient environment and the efficacy of the recovered NaCl in the regenerating cycle of the exhausted IXs. Our findings demonstrated that although the recovered NaCl from the stand-alone MSED can restore nearly 60% ion exchange capacity of the exhausted IXs, coupling MSED with DCMD led to minimizing the consumption of fresh NaCl (in the IX regeneration cycle) significantly, the potential application of NOM in agriculture and diminishing the risk of the IX spent brine disposal. In addition, the initial characteristics of the ion permselective membranes were maintained after 24 h of MSED and the transmembrane flux was increased when the feed/hot compartment (in the DCMD stack) was encapsulated on two outer ends with coolant/permeate compartments as a result of less heat loss to the ambient environment.

ACS Style

Maryam Haddad; Laurent Bazinet; Benoit Barbeau. Towards Water, Sodium Chloride and Natural Organic Matter Recovery from Ion Exchange Spent Brine. Membranes 2021, 11, 262 .

AMA Style

Maryam Haddad, Laurent Bazinet, Benoit Barbeau. Towards Water, Sodium Chloride and Natural Organic Matter Recovery from Ion Exchange Spent Brine. Membranes. 2021; 11 (4):262.

Chicago/Turabian Style

Maryam Haddad; Laurent Bazinet; Benoit Barbeau. 2021. "Towards Water, Sodium Chloride and Natural Organic Matter Recovery from Ion Exchange Spent Brine." Membranes 11, no. 4: 262.

Journal article
Published: 30 March 2021 in Advances in Nutrition: An International Review Journal
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More than a year has passed since the first reported case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection in the city of Wuhan in China's Hubei Province. Until now, few antiviral medications (e.g., remdesivir) or drugs that target inflammatory complications associated with SARS-CoV2 infection have been considered safe by public health authorities. By the end of November 2020, this crisis had led to >1 million deaths and revealed the high susceptibility of people with pre-existing comorbidities (e.g., obesity, diabetes, coronary heart disease, hypertension) to suffer from a severe form of the disease. Elderly people have also been found to be highly susceptible to SARS-CoV2 infection and morbidity. Gastrointestinal manifestations and gut microbial alterations observed in SARS-CoV2–infected hospitalized patients have raised awareness of the potential role of intestinal mechanisms in increasing the severity of the disease. It is therefore critically important to find alternative or complementary approaches, not only to prevent or treat the disease, but also to reduce its growing societal and economic burden. In this review, we explore potential nutritional strategies that implicate the use of polyphenols, probiotics, vitamin D, and ω-3 fatty acids with a focus on the gut microbiome, and that could lead to concrete recommendations that are easily applicable to both vulnerable people with pre-existing metabolic comorbidities and the elderly, but also to the general population.

ACS Style

Laurence Daoust; Geneviève Pilon; André Marette. Perspective: Nutritional Strategies Targeting the Gut Microbiome to Mitigate COVID-19 Outcomes. Advances in Nutrition: An International Review Journal 2021, 12, 1074 -1086.

AMA Style

Laurence Daoust, Geneviève Pilon, André Marette. Perspective: Nutritional Strategies Targeting the Gut Microbiome to Mitigate COVID-19 Outcomes. Advances in Nutrition: An International Review Journal. 2021; 12 (4):1074-1086.

Chicago/Turabian Style

Laurence Daoust; Geneviève Pilon; André Marette. 2021. "Perspective: Nutritional Strategies Targeting the Gut Microbiome to Mitigate COVID-19 Outcomes." Advances in Nutrition: An International Review Journal 12, no. 4: 1074-1086.

Journal article
Published: 22 March 2021 in Environments
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Exposure to persistent organic pollutants (POPs) is associated with insulin resistance while folic acid (FA) may offer a protective effect. However, the paternal contribution to metabolic phenotypes in offspring is not well known yet. Hence, we investigated whether maternal exposure to POPs affects glucose homeostasis and whether maternal FA supplementation counteracts POP effects transmitted via male descendants. Sprague–Dawley founder dams (F0) were fed a diet containing 2 or 6 mg/kg of FA and were force-fed with either a POP mixture or corn oil for 9 weeks. Subsequent male descendants did not receive any treatment. Blood glucose, plasma insulin and C-peptide were measured during an oral glucose tolerance test in males aged 90 and 180 days from generation 1 (F1), 2 (F2) and 3 (F3). Prenatal POP exposure increased fasting glucose in 90-day-old F1 males and C-peptide in 90-day-old F2 males. Prenatal FA supplementation decreased C-peptide in 90 and 180-day-old F1 males. In 180-day-old F3 males, FA supplementation counteracted POPs on fasting and postglucose C-peptide, indicating reduced insulin secretion. Prenatal exposure to an environmentally relevant POP mixture caused abnormalities in glucose homeostasis that are transmitted from one generation to the next through the paternal lineage. Prenatal FA supplementation counteracted some of the deleterious effects of POPs on glucose homeostasis.

ACS Style

Pauline Navarro; Mathieu Dalvai; Phanie L. Charest; Pauline Herst; Maryse Lessard; Bruno Marcotte; Nadine Leblanc; Sarah Kimmins; Jacquetta Trasler; Amanda MacFarlane; André Marette; Janice L. Bailey; Hélène Jacques. Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants. Environments 2021, 8, 24 .

AMA Style

Pauline Navarro, Mathieu Dalvai, Phanie L. Charest, Pauline Herst, Maryse Lessard, Bruno Marcotte, Nadine Leblanc, Sarah Kimmins, Jacquetta Trasler, Amanda MacFarlane, André Marette, Janice L. Bailey, Hélène Jacques. Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants. Environments. 2021; 8 (3):24.

Chicago/Turabian Style

Pauline Navarro; Mathieu Dalvai; Phanie L. Charest; Pauline Herst; Maryse Lessard; Bruno Marcotte; Nadine Leblanc; Sarah Kimmins; Jacquetta Trasler; Amanda MacFarlane; André Marette; Janice L. Bailey; Hélène Jacques. 2021. "Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants." Environments 8, no. 3: 24.

Journal article
Published: 17 February 2021 in Nature Communications
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Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) and at thermoneutrality (T30 °C). Concomitant with microbiota changes, mice fed the Methylococcus-based western diet exhibit improved glucose regulation, reduced body and liver fat, and diminished hepatic immune infiltration. Intake of the Methylococcu-based diet markedly boosts Parabacteroides abundances in a manner depending on adaptive immunity, and upregulates triple positive (Foxp3+RORγt+IL-17+) regulatory T cells in the small and large intestine. Collectively, these data point to the potential for leveraging the use of McB lysates to improve immunometabolic homeostasis.

ACS Style

Benjamin A. H. Jensen; Jacob B. Holm; Ida S. Larsen; Nicole von Burg; Stefanie Derer; Si B. Sonne; Simone I. Pærregaard; Mads V. Damgaard; Stine A. Indrelid; Aymeric Rivollier; Anne-Laure Agrinier; Karolina Sulek; Yke J. Arnoldussen; Even Fjære; André Marette; Inga L. Angell; Knut Rudi; Jonas T. Treebak; Lise Madsen; Caroline Piercey Åkesson; William Agace; Christian Sina; Charlotte R. Kleiveland; Karsten Kristiansen; Tor E. Lea. Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism. Nature Communications 2021, 12, 1 -19.

AMA Style

Benjamin A. H. Jensen, Jacob B. Holm, Ida S. Larsen, Nicole von Burg, Stefanie Derer, Si B. Sonne, Simone I. Pærregaard, Mads V. Damgaard, Stine A. Indrelid, Aymeric Rivollier, Anne-Laure Agrinier, Karolina Sulek, Yke J. Arnoldussen, Even Fjære, André Marette, Inga L. Angell, Knut Rudi, Jonas T. Treebak, Lise Madsen, Caroline Piercey Åkesson, William Agace, Christian Sina, Charlotte R. Kleiveland, Karsten Kristiansen, Tor E. Lea. Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism. Nature Communications. 2021; 12 (1):1-19.

Chicago/Turabian Style

Benjamin A. H. Jensen; Jacob B. Holm; Ida S. Larsen; Nicole von Burg; Stefanie Derer; Si B. Sonne; Simone I. Pærregaard; Mads V. Damgaard; Stine A. Indrelid; Aymeric Rivollier; Anne-Laure Agrinier; Karolina Sulek; Yke J. Arnoldussen; Even Fjære; André Marette; Inga L. Angell; Knut Rudi; Jonas T. Treebak; Lise Madsen; Caroline Piercey Åkesson; William Agace; Christian Sina; Charlotte R. Kleiveland; Karsten Kristiansen; Tor E. Lea. 2021. "Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism." Nature Communications 12, no. 1: 1-19.

Journal article
Published: 16 February 2021 in Membranes
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The presence of membrane fouling is the main drawback in membrane processes, and it is related to the premature use and high cost for the replacement of membranes. Polyphenols in cranberry juice are associated with ion-exchange membrane fouling, and it results in a loss of these beneficial compounds in the juice when treated by membrane processes such as electrodialysis. In the present work, four heterogeneous or pseudohomogeneous cation-exchange membranes (CSE-fg, MK-40, CEM Type-ll, and CJMC-5), different in terms of the polymer matrix (aromatic, aliphatic), exchange capacity, size, and location of meso and macropores, were studied to understand the impact of the membrane structure and physico-chemical properties on adsorption and desorption of phenolic compounds (anthocyanins and proanthocyanidins) from cranberry juice. It appeared from these results that MK-40, CEM Type-ll, and CSE-fg were more prone to fouling due to their high ion-exchange capacity, their thickness, and the presence of meso and macropores in their structure. Indeed, electrostatic interactions occurred between fixed groups of membranes and polyphenolic ions. Desorption of the entire membrane and cryogenic grinding with pH adjusted to 10 allowed a better recovery of anthocyanins and proanthocyanidins (PACs), respectively, since hydroxide ions competed with polyphenols and membrane that induced desorption of polyphenols. In the future, this new knowledge will become the basis for a more sensible choice of membranes and for the development of protocols for extending their lifetime.

ACS Style

Véronique Perreault; Veronika Sarapulova; Ksenia Tsygurina; Natalia Pismenskaya; Laurent Bazinet. Understanding of Adsorption and Desorption Mechanisms of Anthocyanins and Proanthocyanidins on Heterogeneous and Homogeneous Cation-Exchange Membranes. Membranes 2021, 11, 136 .

AMA Style

Véronique Perreault, Veronika Sarapulova, Ksenia Tsygurina, Natalia Pismenskaya, Laurent Bazinet. Understanding of Adsorption and Desorption Mechanisms of Anthocyanins and Proanthocyanidins on Heterogeneous and Homogeneous Cation-Exchange Membranes. Membranes. 2021; 11 (2):136.

Chicago/Turabian Style

Véronique Perreault; Veronika Sarapulova; Ksenia Tsygurina; Natalia Pismenskaya; Laurent Bazinet. 2021. "Understanding of Adsorption and Desorption Mechanisms of Anthocyanins and Proanthocyanidins on Heterogeneous and Homogeneous Cation-Exchange Membranes." Membranes 11, no. 2: 136.

Communication
Published: 26 January 2021 in Polymers
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The implementation of gold-hydrogel core-shell nanomaterials in novel light-driven technologies requires the development of well-controlled and scalable synthesis protocols with precisely tunable properties. Herein, new insights are presented concerning the importance of using the concentration of gold cores as a control parameter in the seeded precipitation polymerization process to modulate—regardless of core size—relevant fabrication parameters such as encapsulation yield, particle size and shrinkage capacity. Controlling the number of nucleation points results in the facile tuning of the encapsulation process, with yields reaching 99% of gold cores even when using different core sizes at a given particle concentration. This demonstration is extended to the encapsulation of bimodal gold core mixtures with equally precise control on the encapsulation yield, suggesting that this principle could be extended to encapsulating cores composed of other materials. These findings could have a significant impact on the development of stimuli-responsive smart materials.

ACS Style

Adolfo Sepúlveda; Audrey Picard-Lafond; André Marette; Denis Boudreau. Nucleation Points: The Forgotten Parameter in the Synthesis of Hydrogel-Coated Gold Nanoparticles. Polymers 2021, 13, 373 .

AMA Style

Adolfo Sepúlveda, Audrey Picard-Lafond, André Marette, Denis Boudreau. Nucleation Points: The Forgotten Parameter in the Synthesis of Hydrogel-Coated Gold Nanoparticles. Polymers. 2021; 13 (3):373.

Chicago/Turabian Style

Adolfo Sepúlveda; Audrey Picard-Lafond; André Marette; Denis Boudreau. 2021. "Nucleation Points: The Forgotten Parameter in the Synthesis of Hydrogel-Coated Gold Nanoparticles." Polymers 13, no. 3: 373.

Journal article
Published: 01 January 2021 in Journal of Lipid and Atherosclerosis
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Gut microbes dictate critical features of host immunometabolism. Certain bacterial components and metabolites (termed postbiotics) mitigate cardiometabolic diseases whereas others potentiate pathological processes. In this review, we discuss key aspects related to the usefulness of bacterial-related molecules strategically positioned as promising treatment strategies for cardiometabolic diseases.

ACS Style

Fernando F. Anhê; Benjamin A. H. Jensen; Lais Rossi Perazza; André Tchernof; Jonathan D. Schertzer; André Marette. Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases. Journal of Lipid and Atherosclerosis 2021, 10, 123 -129.

AMA Style

Fernando F. Anhê, Benjamin A. H. Jensen, Lais Rossi Perazza, André Tchernof, Jonathan D. Schertzer, André Marette. Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases. Journal of Lipid and Atherosclerosis. 2021; 10 (2):123-129.

Chicago/Turabian Style

Fernando F. Anhê; Benjamin A. H. Jensen; Lais Rossi Perazza; André Tchernof; Jonathan D. Schertzer; André Marette. 2021. "Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases." Journal of Lipid and Atherosclerosis 10, no. 2: 123-129.