Efficient NO photorelease is observed in cis (Cl,Cl)-[Ru ^II (FT)Cl ₂ (NO)](PF ₆ ) and trans (Cl,Cl)-[Ru ^II (FT)Cl ₂ (NO)](PF ₆ ) with a quantum yield of 0.31 and 0.10 respectively.

A series of four ruthenium(II) complexes built from the [Ru(terpy)(bipy)(NO)]³⁺ core (terpy is 2,2′:6′,2′′-terpyridine and bipy is 2,2′-bipyridine) are investigated. They differ by the presence of zero, one, two, or three 4′-(4-methoxyphenyl) (MP) electron donor substituents introduced at different positions on the pyridine fragments to increase the intramolecular charge transfer capabilities towards the strongly withdrawing nitrosyl (NO) ligand. The UV-visible spectra reflect the presence and position of the MP substituents on the complexes. In the case of species containing the 4′-(MP)-terpy ligand, a low-lying transition is identified as arising from 4′-(MP)-terpy to Ru(NO) intramolecular charge transfer, which is further confirmed by TD-DFT analysis. Irradiation performed at λ = 436 nm on this isolated transition for different complexes leads to quantum yields of NO photo-release equal to 0.002 and 0.011, in a ratio of 6 (instead of 1), which allows concluding non-ambiguously that a single electron transition cannot account for the NO release mechanism.

The synthesis and behavior in water of a set of various cis (Cl,Cl)-[R-tpyRuCl ₂ (NO)](PF ₆ ) and trans (Cl,Cl)-[R-tpyRuCl ₂ (NO)](PF ₆ ) (R = fluorenyl, phenyl, thiophenyl; tpy = 2,2′:6′,2′′-terpyridine) complexes are presented.