Maciej Sałaga

Dr. Maciej Sałaga

Department of Biochemistry, Medical University of Lodz, Lodz, Poland
orcid

Research Focus & Metrics

Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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Verified
Journal Article
Open access
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ATAgata Twardowska
Agata Twardowska
AMAdam Makaro
Adam Makaro
ABAgata Binienda
Agata Binienda
JFJakub Fichna
Jakub Fichna
Maciej SałagaMaciej Sałaga
Maciej Sałaga
Leaky gut syndrome is a medical condition characterized by intestinal hyperpermeability. Since the intestinal barrier is one of the essential components maintaining homeostasis along the gastrointestinal tract, loss of its integrity due to changes in bacterial composition, decreased expression levels of tight junction proteins, and increased concentration of pro-inflammatory cytokines may lead to intestinal hyperpermeability followed by the development of gastrointestinal and non-gastrointestinal diseases. Translocation of microorganisms and their toxic metabolites beyond the gastrointestinal tract is one of the fallouts of the leaky gut syndrome. The presence of intestinal bacteria in sterile tissues and distant organs may cause damage due to chronic inflammation and progression of disorders, including inflammatory bowel diseases, liver cirrhosis, and acute pancreatitis. Currently, there are no medical guidelines for the treatment or prevention of bacterial translocation in patients with the leaky gut syndrome; however, several studies suggest that dietary intervention can improve barrier function and restrict bacteria invasion. This review contains current literature data concerning the influence of diet, dietary supplements, probiotics, and drugs on intestinal permeability and bacterial translocation.

Verified
Journal Article
Open access
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ABAgata Binienda
Agata Binienda
ATAgata Twardowska
Agata Twardowska
AMAdam Makaro
Adam Makaro
Maciej SałagaMaciej Sałaga
Maciej Sałaga
This review summarizes the recent knowledge on the effects of dietary carbohydrates and lipids on the pathophysiology of leaky gut syndrome (LGS). Alterations in intestinal barrier permeability may lead to serious gastrointestinal (GI) disorders. LGS is caused by intestinal hyperpermeability due to changes in the expression levels and functioning of tight junctions. The influence of dietary habits on intestinal physiology is clearly visible in incidence rates of intestinal diseases in industrial and developing countries. Diseases which are linked to intestinal hyperpermeability tend to localize to Westernized countries, where a diet rich in fats and refined carbohydrates predominates. Several studies suggest that fructose is one of the key carbohydrates involved in the regulation of the intestinal permeability and its overuse may cause harmful effects, such as tight junction protein dysfunction. On the other hand, short chain fatty acids (mainly butyrate) at appropriate concentrations may lead to the reduction of intestinal permeability, which is beneficial in LGS. However, long chain fatty acids, including n-3 and n-6 polyunsaturated fatty acids have unclear properties. Some of those behave as components untightening and tightening the intestinal membrane.

1 January 2021 in Critical Reviews in Oncology/Hematology
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Journal Article
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Anna ZielińskaAnna Zielińska
Anna Zielińska
MWMarcin Włodarczyk
Marcin Włodarczyk
AMAdam Makaro
Adam Makaro
Maciej SałagaMaciej Sałaga
Maciej Sałaga
JFJakub Fichna
Jakub Fichna

1 February 2020 in Pharmacological Research
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Journal Article
Closed access
ABAdrian Bartoszek
Adrian Bartoszek
EMEe Von Moo
Ee Von Moo
ABAgata Binienda
Agata Binienda
AFAdam Fabisiak
Adam Fabisiak
JKJulia B. Krajewska
Julia B. Krajewska
JFJakub Fichna
Jakub Fichna

19 December 2018 in International Journal of Colorectal Disease
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Journal Article
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Anna ZielińskaAnna Zielińska
Anna Zielińska
Maciej SałagaMaciej Sałaga
Maciej Sałaga
MWMarcin Włodarczyk
Marcin Włodarczyk
JFJakub Fichna
Jakub Fichna
Introduction Visceral pain is a symptom reported by over 70% of inflammatory bowel disease (IBD) sufferers. So far, a single, specific cause of this debilitating state has not been established. Chronic pain is one of the most important factors decreasing the quality of life in IBD course. Concurrently, management of pain is the most challenging issue encountered by clinicians in IBD treatment. Areas covered This review focuses on pathophysiology of inflammatory bowel disease-caused visceral pain and explores currently available approaches to its management. We also covered recent pharmacological developments in the field. Conclusions Pain-related disability has major effects on quality of life and on functional and social outcomes in IBD patients. Currently, there is no one standardized method of managing chronic visceral pain in IBD. Therefore, future development, focusing primarily on alleviating the pain, but also on reducing inflammation, is essential.

29 July 2019 in Naunyn-Schmiedeberg's Archives of Pharmacology
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Journal Article
Open access
HZHubert Zatorski
Hubert Zatorski
Maciej SałagaMaciej Sałaga
Maciej Sałaga
JFJakub Fichna
Jakub Fichna
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic, relapsing, intestinal inflammatory disorders with complex and yet unrevealed pathogenesis in which genetic, immunological, and environmental factors play a role. Nowadays, a higher proportion of elderly IBD patients with coexisting conditions, such as cardiovascular disease and/or diabetes is recorded, who require more complex treatment and became a great challenge for gastroenterologists. Furthermore, some patients do not respond to anti-IBD therapy. These facts, together with increasing comorbidities in patients with IBD, imply that urgent, more complex, novel therapeutic strategies in the treatment are needed. Glucagon-like peptides (GLPs) possess numerous functions in the human body such as lowering blood glucose level, controlling body weight, inhibiting gastric emptying, reducing food ingestion, increasing crypt cell proliferation, and improving intestinal growth and nutrient absorption. Thus, GLPs and dipeptidyl peptidase IV (DPP-IV) inhibitors have recently gained attention in IBD research. Several animal models showed that treatment with GLPs may lead to improvement of colitis. This review presents data on the multitude effects of GLPs in the inflammatory intestinal diseases and summarizes the current knowledge on GLPs, which have the potential to become a novel therapeutic option in IBD therapy.