In this review, the problems of the development of radiopharmaceuticals (RPs) based on alphaemitting radionuclides are discussed. The prospects of application of the radionuclides 227Th, 225Ac, 223Ra,...

In present work, carbon nanomaterials (CNMs) are investigated as potential carriers of ⁶⁸Ga, which is widely used in positron emission tomography (PET) in nuclear medicine. Sorption behavior of ⁶⁸Ga was studied onto CNMs of various structures and chemical compositions: nanodiamonds (ND), reduced graphite oxide (rGiO) and multi-walled carbon nanotubes (MWCNT), as well as their oxidized (ND–COOH) or reduced (rGiO–H, MWCNT–H) forms. The physicochemical properties of the nanoparticles were determined by high resolution transmission electron microscopy, x-ray photoelectron spectroscopy, dynamic light scattering and potentiometric titration. The content of ⁶⁸Ga in the solutions during the study of sorption was determined by gamma-ray spectrometry. The highest degree of ⁶⁸Ga sorption was observed on ND and ND–COOH samples, and the optimal sorption conditions were determined: an aqueous solution with a pH of 5–7, m/V ratio of 50 μg/mL and a room temperature (25 °C). The ⁶⁸Ga@ND and ⁶⁸Ga@ND–COOH conjugates were found to be stable in a model blood solution—phosphate-buffered saline with a pH of 7.3, containing 40 g/L of bovine serum albumin: ⁶⁸Ga desorption from these samples in 90 minutes was no more than 20% at 25 °C and up to 30% at 37 °C. Such a quantity of desorbed ⁶⁸Ga does not harm the body and does not interfere with the PET imaging process. Thus, ND and ND–COOH are promising CNMs for using as carriers of ⁶⁸Ga for PET diagnostics.

The redetermination of the title compound, sodium pertechnate, from single-crystal CCD data recorded both at 296 and 100 K confirms previous studies based on X-ray powder diffraction film data [Schwochau (1962).Z. Naturforsch. Teil A,17, 630; Keller & Kanellakopulos (1963).Radiochim. Acta,1, 107–108] and neutron powder diffraction data using the Rietveld method [Weaveret al.(2017).Inorg. Chem.12, 677–681], but reveals a considerable improvement in precision. The standard uncertainties of the room-temperature structure determination are about seven times lower than those of the neutron diffraction structure determination and about 13 times lower at 100 K, due to the decrease in the amplitude of librations. The crystal expansion could be approximated linearly with a thermal volumic expansion coefficient of 1.19 (12) × 10⁻⁴K⁻¹. NaTcO₄adopts the scheelite (CaWO₄) structure type in space group typeI4₁/awith Na and Tc atoms (both with site symmetry -4) replacing Ca and W atoms, respectively.