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Rafiqul Islam
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

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Research article
Published: 04 August 2021 in ACS Applied Bio Materials
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Lipid-based biocompatible ionic liquids (LBILs) have attracted attention as carriers in transdermal drug delivery systems (TDDSs) because of their lipophilic character. In this study, we report the formulation of a peptide–LBIL complex microencapsulated in an oil phase as a potential carrier for the transdermal delivery of leuprolide acetate as a model hydrophilic peptide. The peptide–LBIL complexes were prepared via a water-in-oil emulsion composed of 1,2-dimyristoyl-sn-glycerol-3-ethyl-phosphatidylcholine (EDMPC), a fatty acid (stearic, oleic, and linoleic acid)-based LBIL, and cyclohexane followed by freeze-drying to remove the water and cyclohexane. Then, the peptide–LBIL complexes were nanodispersed and stabilized in isopropyl myristate (IPM) using sorbitol laurate (Span-20). Ionic-liquid-in-oil nanodispersions (IL/O-NDs) were prepared with varying weight ratios of LBILs and Span-20 as the surfactant and the cosurfactant, respectively. Keeping the overall surfactant constant at 10 wt % in IPM, a 5:5 wt % ratio of surfactant (IL) and cosurfactant (Span-20) in the IL/O-NDs significantly (p < 0.0001) increased the physiochemical stability, drug-loading capacity, and drug encapsulation efficiency. The in vitro and in vivo peptide delivery across the skin was increased significantly (p < 0.0001) using IL/O-NDs, compared with non-IL-treated groups. Of all of the LBIL-based formulations, [EDMPC][Linoleate]/O-ND was considered the most preferable for a TDDS based on the pharmacokinetic parameters. The transdermal delivery flux with [EDMPC][Linoleate]/O-ND was increased 65-fold compared with the aqueous delivery vehicle. The IL/O-NDs were able to deform the lipid and protein arrangements of the skin layers to enhance the transdermal permeation of the peptide. In vitro and in vivo cytotoxicity studies of the IL/O-NDs revealed the biocompatibility of the LBIL-based formulations. These results indicated that IL/O-NDs are promising biocompatible carriers for lipid–peptide TDDSs.

ACS Style

Shihab Uddin; Rafiqul Islam; Raihan Chowdhury; Rie Wakabayashi; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto. Lipid-Based Ionic-Liquid-Mediated Nanodispersions as Biocompatible Carriers for the Enhanced Transdermal Delivery of a Peptide Drug. ACS Applied Bio Materials 2021, 4, 6256 -6267.

AMA Style

Shihab Uddin, Rafiqul Islam, Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto. Lipid-Based Ionic-Liquid-Mediated Nanodispersions as Biocompatible Carriers for the Enhanced Transdermal Delivery of a Peptide Drug. ACS Applied Bio Materials. 2021; 4 (8):6256-6267.

Chicago/Turabian Style

Shihab Uddin; Rafiqul Islam; Raihan Chowdhury; Rie Wakabayashi; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto. 2021. "Lipid-Based Ionic-Liquid-Mediated Nanodispersions as Biocompatible Carriers for the Enhanced Transdermal Delivery of a Peptide Drug." ACS Applied Bio Materials 4, no. 8: 6256-6267.

Journal article
Published: 24 April 2020 in Pharmaceutics
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The transdermal delivery of sparingly soluble drugs is challenging due to of the need for a drug carrier. In the past few decades, ionic liquid (IL)-in-oil microemulsions (IL/O MEs) have been developed as potential carriers. By focusing on biocompatibility, we report on an IL/O ME that is designed to enhance the solubility and transdermal delivery of the sparingly soluble drug, acyclovir. The prepared MEs were composed of a hydrophilic IL (choline formate, choline lactate, or choline propionate) as the non-aqueous polar phase and a surface-active IL (choline oleate) as the surfactant in combination with sorbitan laurate in a continuous oil phase. The selected ILs were all biologically active ions. Optimized pseudo ternary phase diagrams indicated the MEs formed thermodynamically stable, spherically shaped, and nano-sized (90%) with the ME compared with Dulbecco’s phosphate-buffered saline, indicates the biocompatibility of the ME. Therefore, we conclude that IL/O ME may be a promising nano-carrier for the transdermal delivery of sparingly soluble drugs.

ACS Style

Rafiqul Islam; Raihan Chowdhury; Rie Wakabayashi; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto. Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug. Pharmaceutics 2020, 12, 392 .

AMA Style

Rafiqul Islam, Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto. Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug. Pharmaceutics. 2020; 12 (4):392.

Chicago/Turabian Style

Rafiqul Islam; Raihan Chowdhury; Rie Wakabayashi; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto. 2020. "Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug." Pharmaceutics 12, no. 4: 392.

Comparative study
Published: 18 April 2020 in International Journal of Pharmaceutics
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Transdermal delivery of drugs is more challenging for drugs that are insoluble or sparingly soluble in water and most organic solvents. To overcome this problem, ionic liquid (IL)-mediated ternary systems have been suggested as potential drug carriers. Here, we report potent ternary (IL–EtOH–IPM) systems consisting of biocompatible ILs, ethanol (EtOH), and isopropyl myristate (IPM) that can dissolve a significant amount of the sparingly soluble drug acyclovir (ACV). The ternary systems were optically transparent and thermodynamically stable with a wide range of IL pertinence. An in vitro drug permeation study showed that the ILs in the ternary systems dramatically enhanced ACV permeation into and across the skin. Fourier Transform Infrared spectroscopy of the stratum corneum (sc) after treatment with ternary systems showed that the skin barrier function was reduced by disturbance of the regularly ordered arrangement of corneocytes and modification of the surface properties of the sc during permeation. Histological analysis, and skin irritation studies using a reconstructed human epidermis model showed the safety profile of the ternary system, and there were no significant changes in the structures of the sc, epidermis, and dermis. Therefore, ternary systems containing biocompatible ILs are promising for transdermal delivery of insoluble or sparingly soluble drugs.

ACS Style

Rafiqul Islam; Raihan Chowdhury; Rie Wakabayashi; Yoshiro Tahara; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto. Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir. International Journal of Pharmaceutics 2020, 582, 119335 .

AMA Style

Rafiqul Islam, Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto. Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir. International Journal of Pharmaceutics. 2020; 582 ():119335.

Chicago/Turabian Style

Rafiqul Islam; Raihan Chowdhury; Rie Wakabayashi; Yoshiro Tahara; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto. 2020. "Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir." International Journal of Pharmaceutics 582, no. : 119335.

Original paper
Published: 02 January 2018 in Cellulose
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Natural fiber reinforced polymer composites are extensively used in various applications such as automotive interiors, furniture, packaging and construction materials. In the present work, teak or shegun (Tectona grandis) sawdust were used as reinforcements in thermoplastics. Sawdust fibers were chemically treated to reduce their moisture absorption. Sawdust pretreated with alkali was then treated with benzoyl peroxide to provide a more hydrophobic surface that would adsorb less water and have better interfacial adhesion. Reaction parameters such as time, temperature, pH and concentration of benzoyl peroxide were used to get the desired change in functional group of cellulose. FT-IR spectroscopic analyses were done and the results showed the evidence of positive reactions. In this work, chemically treated and untreated teak sawdust reinforced high density polyethylene (HDPE) composites were prepared by compression moulding technique. The effects of this chemical treatment on the physico-mechanical properties of the composites were studied. The effect of fiber content on the physico-mechanical properties of composites were also studied by preparing the composites with different weight fractions (5, 15, 25, 35 and 45%) of sawdust. Water absorption (%) tests for all composites revealed that there was less water absorption for the treated composites than the untreated ones. Scanning electron microscopy (SEM) images of treated and untreated sawdust-HDPE composites showed that better interfacial adhesion has occurred between the fiber and the matrix in benzoyl peroxide treated sawdust-HDPE composites. Mechanical properties (tensile strength, elongation at break and impact strength) were determined and analyzed for all treated and untreated sawdust-HDPE composites. Improved tensile and impact results of treated sawdust-HDPE composites indicated that benzoyl peroxide treatment of sawdust increases the interfacial adhesion between fiber-matrix in the treated sawdust-HDPE composites.

ACS Style

Taslima Akter; Husna P. Nur; Shahin Sultana; Rafiqul Islam; Joynal Abedin; Zahidul Islam. Evaluation of mechanical properties of both benzoyl peroxide treated and untreated teak sawdust reinforced high density polyethylene composites. Cellulose 2018, 25, 1171 -1184.

AMA Style

Taslima Akter, Husna P. Nur, Shahin Sultana, Rafiqul Islam, Joynal Abedin, Zahidul Islam. Evaluation of mechanical properties of both benzoyl peroxide treated and untreated teak sawdust reinforced high density polyethylene composites. Cellulose. 2018; 25 (2):1171-1184.

Chicago/Turabian Style

Taslima Akter; Husna P. Nur; Shahin Sultana; Rafiqul Islam; Joynal Abedin; Zahidul Islam. 2018. "Evaluation of mechanical properties of both benzoyl peroxide treated and untreated teak sawdust reinforced high density polyethylene composites." Cellulose 25, no. 2: 1171-1184.