Despite growing recognition of neglectful, abusive, and disrespectful treatment of women during childbirth in health facilities, there is no consensus at a global level on how these occurrences are defined and measured. This mixed-methods systematic review aims to synthesize qualitative and quantitative evidence on the mistreatment of women during childbirth in health facilities to inform the development of an evidence-based typology of the phenomenon. We searched PubMed, CINAHL, and Embase databases and grey literature using a predetermined search strategy to identify qualitative, quantitative, and mixed-methods studies on the mistreatment of women during childbirth across all geographical and income-level settings. We used a thematic synthesis approach to synthesize the qualitative evidence and assessed the confidence in the qualitative review findings using the CERQual approach. In total, 65 studies were included from 34 countries. Qualitative findings were organized under seven domains: (1) physical abuse, (2) sexual abuse, (3) verbal abuse, (4) stigma and discrimination, (5) failure to meet professional standards of care, (6) poor rapport between women and providers, and (7) health system conditions and constraints. Due to high heterogeneity of the quantitative data, we were unable to conduct a meta-analysis; instead, we present descriptions of study characteristics, outcome measures, and results. Additional themes identified in the quantitative studies are integrated into the typology. This systematic review presents a comprehensive, evidence-based typology of the mistreatment of women during childbirth in health facilities, and demonstrates that mistreatment can occur at the level of interaction between the woman and provider, as well as through systemic failures at the health facility and health system levels. We propose this typology be adopted to describe the phenomenon and be used to develop measurement tools and inform future research, programs, and interventions. In 2000, as Millennium Development Goal (MDG) 5, world leaders set a target of reducing the global maternal mortality ratio—the number of deaths among women caused by pregnancy- or childbirth-related complications (maternal deaths) per 100,000 live births—to a quarter of its 1990 level by 2015. MDG 5, along with seven other MDGs, was designed to alleviate extreme poverty by 2015. Although progress towards MDG 5 (and towards the other MDGs) has been good, in 2013, the global maternal mortality ratio was still 210, well above the target of 95. In that year alone, nearly 300,000 women, 99% them living in low- and middle-income countries, died from pregnancy- or childbirth-related complications. Most of these maternal deaths were caused by hemorrhage (severe bleeding) after childbirth, post-delivery infections, obstructed (difficult) labor, or blood pressure disorders during pregnancy. These conditions are largely preventable if women have access to good-quality reproductive health services and if trained birth attendants are present during childbirth. The rates of skilled birth attendance and of facility-based childbirth have risen in resource-limited countries over the past two decades, but almost a third of women in these countries still deliver without a skilled birth attendant. Among the numerous obstacles likely to prevent further increases in the proportion of women delivering in a health facility is women’s fear of mistreatment during delivery. Women need to be sure that they will receive dignified and respectful care during childbirth. Unfortunately, recent studies have indicated that women are often exposed to neglectful, abusive, and disrespectful care (care that local consensus regards as humiliating or undignified) during childbirth in health facilities. There is currently no consensus about how to define and measure the mistreatment of women during childbirth, so here, the researchers develop an evidence-based typology of the mistreatment of women during childbirth in health facilities worldwide by combining information identified in a mixed-methods systematic review. A typology is a systematic classification of objects or behaviors that have characteristics in common. A mixed-methods systematic review identifies all the qualitative and quantitative research on a given topic using predefined criteria. Qualitative research investigates how people feel about a medical intervention; quantitative research provides numerical data about interventions. The researchers identified 65 (mainly qualitative) studies undertaken in 34 countries that investigated the mistreatment of women during childbirth across all geographical and income-level settings. They analyzed the evidence presented in these studies using thematic analysis, an approach that identifies and organizes patterns (themes) within qualitative data. Based on this analysis, the researchers developed a typology of the mistreatment of women during childbirth consisting of seven domains (categories). These domains were physical abuse (for example, slapping or pinching during delivery); sexual abuse; verbal abuse such as harsh or rude language; stigma and discrimination based on age, ethnicity, socioeconomic status, or medical conditions; failure to meet professional standards of care (for example, neglect during delivery); poor rapport between women and providers, including ineffective communication, lack of supportive care, and loss of autonomy; and health system conditions and constraints such as the lack of the resources needed to provide women with privacy. These findings illustrate how women’s experiences of childbirth worldwide are marred by mistreatment. Moreover, they indicate that, although the mistreatment of women during delivery in health facilities often occurs at the level of the interaction between women and healthcare providers, systemic failures at the levels of the health facility and the health system also...