Prof. Pnina Brodt is a Professor in the Departments of Surgery, Medicine and Oncology at McGill University and a Senior Scientist at the Research Institute-McGill University Health Center where she was a co-leader of the Cancer Axis. She was a co-founder of the international Liver Metastasis Research Network where she still plays an active role. Her research work has focused on the biology of cancer metastasis, particularly cellular/molecular aspects of the process of liver metastasis and the regulation and role of the tumor microenvironment in the liver. The work led to the development of several strategies for blockade of the IGF-I axis including, most recently, the bio-engineering of an IGF-Trap that is currently being developed as an anti-cancer drug. Her research topics include mainly metastasis, colon cancer, pancreatic cancer, the tumor microenvironment, inflammation, IGF, and targeted cancer therapeutics.