This paper provides a literature review of the cascade refrigeration system (CRS). It is an important system that can achieve an evaporating temperature as low as −170 °C and broadens the refrigeration temperature range of conventional systems. In this paper, several research options such as various designs of CRS, studies on refrigerants, and optimization works on the systems are discussed. Moreover, the influence of parameters on system performance, the economic analysis, and applications are defined, followed by conclusions and suggestions for future studies.