Michele Montrone

Dr. Michele Montrone

IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy
orcid

Research Focus & Metrics

Academic Career Length

22Years (2005-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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18 April 2005 in Clinical and Experimental Immunology
Verified
Journal Article
Closed access
PDF file
DSD. Sansonno
D. Sansonno
GLGianfranco Lauletta
Gianfranco Lauletta
MMMichele Montrone
Michele Montrone
GGG. Grandaliano
G. Grandaliano
FSF. P. Schena
F. P. Schena
FDF. Dammacco
F. Dammacco

1 September 2008 in Blood
Verified
Journal Article
Closed access
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DSDomenico Sansonno
Domenico Sansonno
FTFelicia Anna Tucci
Felicia Anna Tucci
LTLaura Troiani
Laura Troiani
GLGianfranco Lauletta
Gianfranco Lauletta
MMMichele Montrone
Michele Montrone
FDFranco Dammacco
Franco Dammacco
Chemokine CXCL13, also known as BCA-1 (B cell–attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), is a major regulator of B-cell trafficking. Hepatitis C virus (HCV) infection may be associated with B-cell dysfunction and lymphoproliferative disorders, including mixed cryoglobulinemia (MC). This study evaluates circulating levels of CXCL13 protein and specific mRNA expression in chronically HCV-infected patients with and without MC. Compared with healthy controls and HCV-infected patients without MC, CXCL13 serum levels were significantly higher in MC patients. The highest CXCL13 levels strongly correlated with active cutaneous vasculitis. CXCL13 gene expression in portal tracts, isolated from liver biopsy tissues with laser capture microdissection, showed enhanced levels of specific mRNA in MC patients with active cutaneous vasculitis. Specific CXCL13 gene mRNA expression was also up-regulated in skin tissue of these patients. These findings paralleled specific deposits of CXCL13 protein both in the liver and in the skin. Our results indicate that up-regulation of CXCL13 gene expression is a distinctive feature of HCV-infected patients. Higher levels of this chemokine in the liver as well as in the skin of patients with active MC vasculitis suggest a possible interrelation between these biologic compartments.


Verified
Journal Article
Open access
PDF file
VLVito Longo
Vito Longo
ACAnnamaria Catino
Annamaria Catino
MMMichele Montrone
Michele Montrone
EMElisabetta Sara Montagna
Elisabetta Sara Montagna
FPFrancesco Pesola
Francesco Pesola
DGDomenico Galetta
Domenico Galetta
Recently, the fifth edition of the WHO classification recognized the thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) as a separate entity from conventional non-small cell lung cancer with SMARCA4 deficiency because of the different clinicopathological characteristics of these two diseases. SMARCA4-UT mainly occurs in young to middle-aged adults and involves a large mass compressing the tissues surrounding the mediastinum and lung parenchyma. Unfortunately, SMARCA4-UT shows a high probability of recurrence after upfront surgery as well as radiotherapy resistance; moreover, chemotherapy has low efficacy. Moreover, given the recent classification of SMARCA4-UT, no data concerning specific clinical trials are currently available. However, several case reports show immunotherapy efficacy in patients with this disease not only in a metastatic setting but also in a neoadjuvant manner, supporting the development of clinical trials. In addition, preclinical data and initial clinical experiences suggest that inhibiting pathways such as CDK4/6, AURKA, ATR, and EZH2 may be a promising therapeutic approach to SMARCA4-UT.

Verified
Journal Article
Open access
PDF file
VLVito Longo
Vito Longo
ACAnnamaria Catino
Annamaria Catino
MMMichele Montrone
Michele Montrone
PPPamela Pizzutilo
Pamela Pizzutilo
Tiziana AnneseTiziana Annese
Tiziana Annese
DGDomenico Galetta
Domenico Galetta
Small-cell lung cancer (SCLC) is an aggressive malignancy that exhibits a rapid doubling time, a high growth fraction, and the early development of widespread metastases. The addition of immune checkpoint inhibitors to first-line chemotherapy represents the first significant improvement of systemic therapy in several decades. However, in contrast to its effects on non-SCLC, the advantageous effects of immunotherapy addition are modest in SCLC. In particular, only a small number of SCLC patients benefit from immune checkpoint inhibitors. Additionally, biomarkers selection is lacking for SCLC, with clinical trials largely focusing on unselected populations. Here, we review the data concerning the major biomarkers for immunotherapy, namely, programmed death ligand 1 expression and tumour mutational burden. Furthermore, we explore other potential biomarkers, including the role of the immune microenvironment in SCLC, the role of genetic alterations, and the potential links between neurological paraneoplastic syndromes, serum anti-neuronal nuclear antibodies, and outcomes in SCLC patients treated with immunotherapy.

20 December 2006 in Clinical and Experimental Immunology
Verified
Journal Article
Open access
PDF file
DSD. Sansonno
D. Sansonno
FTF A Tucci
F A Tucci
GLGianfranco Lauletta
Gianfranco Lauletta
Valli De ReValli De Re
Valli De Re
MMMichele Montrone
Michele Montrone
FDF. Dammacco
F. Dammacco
The relationship between the occurrence of cryoglobulins and hepatitis C virus (HCV) productive infection in peripheral blood and bone marrow-derived lymphocytes was explored. HCV minus strand RNA, the viral replicative intermediate, was searched for by a polyA+ tract strand-specific Tth-based reverse transcriptase–polymerase chain reaction (RT–PCR) in lymphoid cells of 46 patients with acute and chronic infection. The HCV minus strand was demonstrated in RNA extracted from six (13%) and five (11%) peripheral blood and bone marrow-derived lymphocytes, respectively. The HCV replicating form in lymphoid cells was associated strictly with mixed cryoglobulinaemia (MCG), in that it was found in six of 13 (46%) MCG patients, including two with B cell non-Hodgkin's lymphoma (NHL). No traces of HCV-negative strand RNA were found in four patients with acute hepatitis C, in 15 with chronic active hepatitis without extrahepatic disorders, in seven with monoclonal gammopathy of undetermined significance, and in seven with B-NHL without MCG. These results emphasize the direct role of the virus in the pathogenesis of MCG and support the contention that HCV is not specifically lymphotropic, its entry and replication in lymphoid cells being determined largely by selective interactions.