Dr. Tso is focused on the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low-density lipoproteins by the small intestine. The techniques employed consist of conscious intestinal lymph fistula rats, lymph fistula mice, intestinal epithelial cell culture, and molecular biology. Dr. Tso and his colleagues are currently studying how bile salts are involved in the absorption of lipids. In addition, they are also studying the factors regulating the synthesis and secretion of apolipoproteins by the small intestine.