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Fabricating antibacterial hydrogels with antimicrobial drugs and synthetic biocompatible biomimetic hydrogels is a promising strategy for practical medical applications. Here, we report a bicomponent hydrogel composed of a biomimetic polyisocyanopetide (PIC) hydrogel and a photodynamic antibacterial membrane-intercalating conjugated oligoelectrolyte (COE). The aggregation behavior and aggregate size of the COEs in water can be regulated using the PIC hydrogel, which could induce COEs with higher reactive oxygen species (ROS) production efficiency and increased association of COEs toward bacteria, therefore enhancing the antibacterial efficiency. This strategy provides a facile method for developing biomimetic hydrogels with high antibacterial capability.
Changsheng Du; Dong Gao; Mengshi Gao; Hongbo Yuan; Xiaoning Liu; Bing Wang; Chengfen Xing. Property Regulation of Conjugated Oligoelectrolytes with Polyisocyanide to Achieve Efficient Photodynamic Antibacterial Biomimetic Hydrogels. ACS Applied Materials & Interfaces 2021, 1 .
AMA StyleChangsheng Du, Dong Gao, Mengshi Gao, Hongbo Yuan, Xiaoning Liu, Bing Wang, Chengfen Xing. Property Regulation of Conjugated Oligoelectrolytes with Polyisocyanide to Achieve Efficient Photodynamic Antibacterial Biomimetic Hydrogels. ACS Applied Materials & Interfaces. 2021; ():1.
Chicago/Turabian StyleChangsheng Du; Dong Gao; Mengshi Gao; Hongbo Yuan; Xiaoning Liu; Bing Wang; Chengfen Xing. 2021. "Property Regulation of Conjugated Oligoelectrolytes with Polyisocyanide to Achieve Efficient Photodynamic Antibacterial Biomimetic Hydrogels." ACS Applied Materials & Interfaces , no. : 1.
Graphene quantum dots (GQDs) have been successfully used as a highly sensitive probe for the sensing of formaldehyde (HCHO) in an aqueous solution. Through static quenching, the probe utilizes the interaction between HCHO and GQDs to trigger the “turn off” fluorescence response, and has good selectivity. The probe can detect HCHO in a pure aqueous solution, and it also can still detect HCHO in a complex environment with a pH range from 4 to 10. The concentration of HCHO and the fluorescence intensity of GQDs show a good linear relationship within the range of HCHO of 0–1 μg/mL, which was much more sensitive than previous reports. The limit of HCHO detection by GQDs is about 0.0515 μg/mL. In addition, we successfully applied it to the actual food inspection. It is proved to be a selective, sensitive and visualized method to check whether the concentration of HCHO in the foods exceeds the regulatory limit, which presents a potential application in food safety testing.
Yanpeng Zhang; Junjie Qi; Mengying Li; Dong Gao; Chengfen Xing. Fluorescence Probe Based on Graphene Quantum Dots for Selective, Sensitive and Visualized Detection of Formaldehyde in Food. Sustainability 2021, 13, 5273 .
AMA StyleYanpeng Zhang, Junjie Qi, Mengying Li, Dong Gao, Chengfen Xing. Fluorescence Probe Based on Graphene Quantum Dots for Selective, Sensitive and Visualized Detection of Formaldehyde in Food. Sustainability. 2021; 13 (9):5273.
Chicago/Turabian StyleYanpeng Zhang; Junjie Qi; Mengying Li; Dong Gao; Chengfen Xing. 2021. "Fluorescence Probe Based on Graphene Quantum Dots for Selective, Sensitive and Visualized Detection of Formaldehyde in Food." Sustainability 13, no. 9: 5273.
Herein, a feasible and simple bio-hybrid complex based on water-soluble conjugated polymers and Rhodopseudomonas palustris (R. palustris), one kind of photosynthetic bacteria, was constructed for enhancing photocatalytic hydrogen production.
Zijuan Wang; Dong Gao; Hao Geng; Chengfen Xing. Enhancing hydrogen production by photobiocatalysis through Rhodopseudomonas palustris coupled with conjugated polymers. Journal of Materials Chemistry A 2021, 1 .
AMA StyleZijuan Wang, Dong Gao, Hao Geng, Chengfen Xing. Enhancing hydrogen production by photobiocatalysis through Rhodopseudomonas palustris coupled with conjugated polymers. Journal of Materials Chemistry A. 2021; ():1.
Chicago/Turabian StyleZijuan Wang; Dong Gao; Hao Geng; Chengfen Xing. 2021. "Enhancing hydrogen production by photobiocatalysis through Rhodopseudomonas palustris coupled with conjugated polymers." Journal of Materials Chemistry A , no. : 1.
Eine effiziente Strategie zur Konstruktion von glyco‐inside‐Nanoassemblaten wird von Liang Qiu, Ulrich Glebe und Chengfen Xing et al. vorgestellt. In ihrer Zuschrift (DOI: 10.1002/ange.202015692) wird eine Reihe von hoch geordneten glyco‐inside‐Nanoassemblaten, die von Zucker‐dekorierten Blockcopolymeren abgeleitet sind, durch PISA erhalten, induziert durch RAFT‐Dispersionspolymerisation eines Galaktose‐dekorierten Monomers.
Liang Qiu; Haoran Zhang; Thomas Bick; Johannes Martin; Petra Wendler; Alexander Böker; Ulrich Glebe; Chengfen Xing. Innentitelbild: Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer (Angew. Chem. 20/2021). Angewandte Chemie 2021, 133, 11098 -11098.
AMA StyleLiang Qiu, Haoran Zhang, Thomas Bick, Johannes Martin, Petra Wendler, Alexander Böker, Ulrich Glebe, Chengfen Xing. Innentitelbild: Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer (Angew. Chem. 20/2021). Angewandte Chemie. 2021; 133 (20):11098-11098.
Chicago/Turabian StyleLiang Qiu; Haoran Zhang; Thomas Bick; Johannes Martin; Petra Wendler; Alexander Böker; Ulrich Glebe; Chengfen Xing. 2021. "Innentitelbild: Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer (Angew. Chem. 20/2021)." Angewandte Chemie 133, no. 20: 11098-11098.
An efficient strategy for constructing glyco‐inside nano‐assemblies is presented by Liang Qiu, Ulrich Glebe, Chengfen Xing et al. In their Communication (DOI: 10.1002/anie.202015692), a series of highly ordered glyco‐inside nano‐assemblies derived from sugar‐decorated block copolymers were obtained via PISA induced by RAFT dispersion polymerization of a galactose‐decorated monomer.
Liang Qiu; Haoran Zhang; Thomas Bick; Johannes Martin; Petra Wendler; Alexander Böker; Ulrich Glebe; Chengfen Xing. Inside Cover: Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer (Angew. Chem. Int. Ed. 20/2021). Angewandte Chemie International Edition 2021, 60, 10998 -10998.
AMA StyleLiang Qiu, Haoran Zhang, Thomas Bick, Johannes Martin, Petra Wendler, Alexander Böker, Ulrich Glebe, Chengfen Xing. Inside Cover: Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer (Angew. Chem. Int. Ed. 20/2021). Angewandte Chemie International Edition. 2021; 60 (20):10998-10998.
Chicago/Turabian StyleLiang Qiu; Haoran Zhang; Thomas Bick; Johannes Martin; Petra Wendler; Alexander Böker; Ulrich Glebe; Chengfen Xing. 2021. "Inside Cover: Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer (Angew. Chem. Int. Ed. 20/2021)." Angewandte Chemie International Edition 60, no. 20: 10998-10998.
Considering recent breakthroughs in the field of optogenetics, a powerful tool is established in the present study to modulate the activities of target neurons through the application of light‐based methods. Near‐infrared (NIR) light enables the penetration of deep‐tissue. As a result, it can be used to modulate the functions of proteins/cells. Herein, it is aimed to develop a NIR light‐sensitive drug delivery system to spatially and temporally control the activation of the loaded drug at the stimulation sites through its release from a nanoparticle sensitive to NIR. Owing to their excellent photothermal effect under NIR irradiation, the nanoparticles are found to penetrate the blood‐brain barrier effectively, ultimately reaching neurons. Furthermore, by loading fasudil, a selective activator of the Kv7.4 potassium channel, into the precisely designed and synthesized NIR light‐sensitive nanoparticles, the firing frequency of dopaminergic neurons in the ventral tegmental area is found to be remarkably reduced upon NIR light irradiation. Such findings shed light on a new concept that can be used for developing more selective drug therapies for the treatment of diseases, such as major depression.
Boying Li; Yiying Wang; Dong Gao; Shuxi Ren; Li Li; Ning Li; Hailong An; Tiantian Zhu; Yakun Yang; Hailin Zhang; Chengfen Xing. Photothermal Modulation of Depression‐Related Ion Channel Function through Conjugated Polymer Nanoparticles. Advanced Functional Materials 2021, 31, 2010757 .
AMA StyleBoying Li, Yiying Wang, Dong Gao, Shuxi Ren, Li Li, Ning Li, Hailong An, Tiantian Zhu, Yakun Yang, Hailin Zhang, Chengfen Xing. Photothermal Modulation of Depression‐Related Ion Channel Function through Conjugated Polymer Nanoparticles. Advanced Functional Materials. 2021; 31 (19):2010757.
Chicago/Turabian StyleBoying Li; Yiying Wang; Dong Gao; Shuxi Ren; Li Li; Ning Li; Hailong An; Tiantian Zhu; Yakun Yang; Hailin Zhang; Chengfen Xing. 2021. "Photothermal Modulation of Depression‐Related Ion Channel Function through Conjugated Polymer Nanoparticles." Advanced Functional Materials 31, no. 19: 2010757.
Glyco‐assemblies derived from amphiphilic sugar‐decorated block copolymers (ASBCs) have emerged prominently due to their wide application e.g. in biomedicine and as drug carriers. However, to efficiently construct these glyco‐assemblies is still a challenge. Here, we report an efficient technology for the synthesis of glyco‐inside nano‐assemblies by utilizing RAFT polymerization of a galactose‐decorated methacrylate for polymerization‐induced self‐assembly (PISA). Using this approach, a series of highly ordered glyco‐inside nano‐assemblies containing intermediate morphologies were fabricated by adjusting the length of the hydrophobic glycoblock and the polymerization solids content. A specific morphology of complex vesicles was captured during the PISA process and the formation mechanism is explained by the morphology of its precursor and intermediate. Thus, this method establishes a powerful route to fabricate glyco‐assemblies with tunable morphologies and variable sizes, which is significant to enable the large‐scale fabrication and wide application of glyco‐assemblies.
Liang Qiu; Haoran Zhang; Thomas Bick; Johannes Martin; Petra Wendler; Alexander Böker; Ulrich Glebe; Chengfen Xing. Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer. Angewandte Chemie International Edition 2021, 60, 11098 -11103.
AMA StyleLiang Qiu, Haoran Zhang, Thomas Bick, Johannes Martin, Petra Wendler, Alexander Böker, Ulrich Glebe, Chengfen Xing. Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer. Angewandte Chemie International Edition. 2021; 60 (20):11098-11103.
Chicago/Turabian StyleLiang Qiu; Haoran Zhang; Thomas Bick; Johannes Martin; Petra Wendler; Alexander Böker; Ulrich Glebe; Chengfen Xing. 2021. "Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer." Angewandte Chemie International Edition 60, no. 20: 11098-11103.
The micelles (CPMs) have a thermoresponsive surface and reactive oxygen species (ROS) generating core. At 37 °C, CPMs captured Aβ aggregates to inhibit and disaggregate aggregates under white-light irradiation, reducing Aβ-induced cytotoxicity.
Hao Geng; Hongbo Yuan; Liang Qiu; Dong Gao; Yongqiang Cheng; Chengfen Xing. Inhibition and disaggregation of amyloid β protein fibrils through conjugated polymer–core thermoresponsive micelles. Journal of Materials Chemistry B 2020, 8, 10126 -10135.
AMA StyleHao Geng, Hongbo Yuan, Liang Qiu, Dong Gao, Yongqiang Cheng, Chengfen Xing. Inhibition and disaggregation of amyloid β protein fibrils through conjugated polymer–core thermoresponsive micelles. Journal of Materials Chemistry B. 2020; 8 (44):10126-10135.
Chicago/Turabian StyleHao Geng; Hongbo Yuan; Liang Qiu; Dong Gao; Yongqiang Cheng; Chengfen Xing. 2020. "Inhibition and disaggregation of amyloid β protein fibrils through conjugated polymer–core thermoresponsive micelles." Journal of Materials Chemistry B 8, no. 44: 10126-10135.
Herein, we have developed a composite antibacterial hydrogel with photodynamic therapy (PDT) and photothermal therapy (PTT) antibacterial capabilities, triggered by white light and NIR light irradiation. A water-insoluble conjugated polymer (PDPP) with photothermal ability was prepared into nanoparticles by nanoprecipitation method, and the cell-penetrating peptide TAT was grafted on the surface of the nanoparticles. Based on our previous work that developed a hybrid hydrogel with enhanced PDT effect from polyisocyanides (PIC) hydrogel and cationic conjugated polythiophene (PMNT), PDPP nanoparticles (CPNs-TAT) with photothermal ability are introduced to realize synergistic antibacteria of PDT and PTT. Using PIC hydrogel to combine PIC and CPNs-TAT has the following advantages. Firstly, PIC hydrogel can regulate the aggregation state of PMNT, making it better dispersed, and improving its capacity of reactive oxygen species (ROS) production. Secondly, CPNs-TAT can be uniformly dispersed in the PIC hybrid, thereby avoiding the toxicity caused by too high local concentration, achieving a uniform increase in system temperature, and enhancing the therapeutic effect of PTT. Thirdly, PIC hybrid has the synergistic treatment effect of PDT and PTT. The PIC hybrid intelligently regulates its antibacterial ability through white light and NIR light, which can be used in the white light and NIR light area. When irradiated with white light and NIR light sequentially, synergistic PDT and PTT exhibit stronger antibacterial ability than PDT or PTT alone. The combination of two antibacterial methods realizes the dual-control antibacterial of PDT and PTT and provides an antibacterial mode based on PIC hybrids. Therefore, the PIC hybrids are promising as antibacterial excipient for clinical wounds.
Qifan Cui; Hongbo Yuan; Xueying Bao; Gang Ma; Manman Wu; Chengfen Xing. Synergistic Photodynamic and Photothermal Antibacterial Therapy Based on a Conjugated Polymer Nanoparticle-Doped Hydrogel. ACS Applied Bio Materials 2020, 3, 4436 -4443.
AMA StyleQifan Cui, Hongbo Yuan, Xueying Bao, Gang Ma, Manman Wu, Chengfen Xing. Synergistic Photodynamic and Photothermal Antibacterial Therapy Based on a Conjugated Polymer Nanoparticle-Doped Hydrogel. ACS Applied Bio Materials. 2020; 3 (7):4436-4443.
Chicago/Turabian StyleQifan Cui; Hongbo Yuan; Xueying Bao; Gang Ma; Manman Wu; Chengfen Xing. 2020. "Synergistic Photodynamic and Photothermal Antibacterial Therapy Based on a Conjugated Polymer Nanoparticle-Doped Hydrogel." ACS Applied Bio Materials 3, no. 7: 4436-4443.
The multifunctional photothermal therapy (PTT) platform with the ability to selectively kill bacteria over mammalian cells has received widespread attention recently. Herein, we prepared graphene oxide-amino(polyethyleneglycol) (GO-PEG-NH2) while using the hydrophobic interaction between heptadecyl end groups of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethyleneglycol)] (DSPE-PEG-NH2) and graphene oxide (GO). Based on GO-PEG-NH2, the versatile PTT system was constructed with simultaneous selective recognition, capturing, and photothermal killing of bacteria. When the cells undergo bacterial infection, owing to the poly(ethylene glycol) (PEG) chains and positively charged amino groups, GO-PEG-NH2 can specifically recognize and capture bacteria in the presence of cells. Meanwhile, the stable photothermal performance of GO-PEG-NH2 enables the captured bacteria to be efficiently photothermally ablated upon the irradiation of 808 nm laser. Besides, the GO-PEG-NH2 is highly stable in various biological media and it exhibits low cytotoxicity, suggesting that it holds great promise for biological applications. This work provides new insight into graphene-based materials as a PTT agent for the development of new therapeutic platforms.
Gang Ma; Junjie Qi; Qifan Cui; Xueying Bao; Dong Gao; Chengfen Xing. Graphene Oxide Composite for Selective Recognition, Capturing, Photothermal Killing of Bacteria over Mammalian Cells. Polymers 2020, 12, 1116 .
AMA StyleGang Ma, Junjie Qi, Qifan Cui, Xueying Bao, Dong Gao, Chengfen Xing. Graphene Oxide Composite for Selective Recognition, Capturing, Photothermal Killing of Bacteria over Mammalian Cells. Polymers. 2020; 12 (5):1116.
Chicago/Turabian StyleGang Ma; Junjie Qi; Qifan Cui; Xueying Bao; Dong Gao; Chengfen Xing. 2020. "Graphene Oxide Composite for Selective Recognition, Capturing, Photothermal Killing of Bacteria over Mammalian Cells." Polymers 12, no. 5: 1116.
By coating photosynthetic bacteria of Rhodopseudomonas (R.) palustris with conjugated polymers nanoparticles modified with positively charged peptide TAT (CPNs-TAT), a bio-optical hybrid composite of R. palustris/CPNs-TAT has been constructed. R. palustris/CPNs-TAT augments the light coverage of R. palustris to broaden the R. palustris absorption due to excellent light-harvesting properties of CPNs-TAT especially in the ultraviolet region. It leads to converting ultraviolet light to visible light that could be absorbed by R. palustris, allowing antenna systems around the reaction center (RC) of photosynthetic membrane to absorb more photons, thus photons are excited and transferred to the RC where electron-hole separation occurs. Therefore, R. palustris/CPNs-TAT improve adenosine triphosphate (ATP) synthesis by increasing proton gradient, resulting in the enhancement of the photosynthetic activity. This effort combines synthetic light-harvesting materials with photosynthetic bacteria without complicated genetic techniques to obtain the hybrid bio-optical systems for augmenting photosynthesis beyond natural photosynthetic bacteria.
Zijuan Wang; Dong Gao; Yong Zhan; Chengfen Xing. Enhancing the Light Coverage of Photosynthetic Bacteria to Augment Photosynthesis by Conjugated Polymer Nanoparticles. ACS Applied Bio Materials 2020, 3, 3423 -3429.
AMA StyleZijuan Wang, Dong Gao, Yong Zhan, Chengfen Xing. Enhancing the Light Coverage of Photosynthetic Bacteria to Augment Photosynthesis by Conjugated Polymer Nanoparticles. ACS Applied Bio Materials. 2020; 3 (5):3423-3429.
Chicago/Turabian StyleZijuan Wang; Dong Gao; Yong Zhan; Chengfen Xing. 2020. "Enhancing the Light Coverage of Photosynthetic Bacteria to Augment Photosynthesis by Conjugated Polymer Nanoparticles." ACS Applied Bio Materials 3, no. 5: 3423-3429.
Calmodulin, as a calcium binding protein involving in the signal pathways of many life activities such as cell proliferation and apoptosis, can be regulated with the near-infrared (NIR) light based photothermal conversation. Here, we build a conjugated polymer nanoparticle (CPNs-C) by assembling poly pyrrole dione (PDPP) and dipalmitoyl phosphatidylethanolamine-polyethylene glycol-maleimide (DSPE-PEG2000-MAL) with a calmodulin antibody modified at the surface, which is NIR light responsive for photothermally inducing apoptosis of cancer cells. Under near-infrared light irradiation, protein kinase B (Akt) and phosphatidylinositol 3-kinase (PI3K), which bind to CaM, reduce the degree of phosphorylation due to the photothermal effect of CPNs-C, thus inhibiting the recruitment of Akt on the cell membrane. Therefore, the phosphorylation of GSK-3β downstream of the signaling pathway is reduced and the phosphorylation of FoxO3a is enhanced, which can promote apoptosis of cancer cells. Compared with the photothermal effect of traditional CPNs, CPNs-C exhibits higher efficiency to regulate signaling pathways to promote cancer cells toward apoptosis. This strategy of utilizing NIR light to regulate the tumor apoptotic signaling pathway provides an effective way to enhance cancer cell apoptosis with high efficiency.
Benkai Bao; Dong Gao; Ning Li; Manman Wu; Chengfen Xing. Near-Infrared Light Regulation of Tumor PI3K/Akt Signaling Pathway for Enhancing Cancer Cell Apoptosis through Conjugated Polymer Nanoparticles. ACS Applied Bio Materials 2020, 3, 2428 -2437.
AMA StyleBenkai Bao, Dong Gao, Ning Li, Manman Wu, Chengfen Xing. Near-Infrared Light Regulation of Tumor PI3K/Akt Signaling Pathway for Enhancing Cancer Cell Apoptosis through Conjugated Polymer Nanoparticles. ACS Applied Bio Materials. 2020; 3 (4):2428-2437.
Chicago/Turabian StyleBenkai Bao; Dong Gao; Ning Li; Manman Wu; Chengfen Xing. 2020. "Near-Infrared Light Regulation of Tumor PI3K/Akt Signaling Pathway for Enhancing Cancer Cell Apoptosis through Conjugated Polymer Nanoparticles." ACS Applied Bio Materials 3, no. 4: 2428-2437.
Hybrid biomimetic hydrogels with enhanced reactive oxygen species (ROS)‐generation efficiency under 600 nm light show high antibacterial activity. The hybrid gels are composed of helical tri(ethylene glycol)‐functionalized polyisocyanides (PICs) and a conformation‐sensitive conjugated polythiophene, poly(3‐(3′‐N,N,N‐triethylammonium‐1′‐propyloxy)‐4‐methyl‐2,5‐thiophene chloride) (PMNT). The PIC polymer serves as a scaffold to trap and align the PMNT backbone into a highly ordered conformation, resulting in redshifted, new sharp bands in the absorption and fluorescence spectra. Similar to PIC, the hybrid closely mimics the mechanical properties of biological gels, such as collagen and fibrin, including the strain stiffening properties at low stresses. Moreover, the PMNT/PIC hybrids show much higher ROS production efficiency under red light than PMNT only, leading to an efficient photodynamic antimicrobial effect towards various pathogenic bacteria.
Hongbo Yuan; Dr. Yong Zhan; Dr. Alan E. Rowan; Dr. Chengfen Xing; Paul Kouwer. Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels. Angewandte Chemie International Edition 2020, 59, 2720 -2724.
AMA StyleHongbo Yuan, Dr. Yong Zhan, Dr. Alan E. Rowan, Dr. Chengfen Xing, Paul Kouwer. Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels. Angewandte Chemie International Edition. 2020; 59 (7):2720-2724.
Chicago/Turabian StyleHongbo Yuan; Dr. Yong Zhan; Dr. Alan E. Rowan; Dr. Chengfen Xing; Paul Kouwer. 2020. "Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels." Angewandte Chemie International Edition 59, no. 7: 2720-2724.
Hybrid biomimetic hydrogels with enhanced reactive oxygen species (ROS)‐generation efficiency under 600 nm light show high antibacterial activity. The hybrid gels are composed of helical tri(ethylene glycol)‐functionalized polyisocyanides (PICs) and a conformation‐sensitive conjugated polythiophene, poly(3‐(3′‐N,N,N‐triethylammonium‐1′‐propyloxy)‐4‐methyl‐2,5‐thiophene chloride) (PMNT). The PIC polymer serves as a scaffold to trap and align the PMNT backbone into a highly ordered conformation, resulting in redshifted, new sharp bands in the absorption and fluorescence spectra. Similar to PIC, the hybrid closely mimics the mechanical properties of biological gels, such as collagen and fibrin, including the strain stiffening properties at low stresses. Moreover, the PMNT/PIC hybrids show much higher ROS production efficiency under red light than PMNT only, leading to an efficient photodynamic antimicrobial effect towards various pathogenic bacteria.
Hongbo Yuan; Dr. Yong Zhan; Dr. Alan E. Rowan; Dr. Chengfen Xing; Dr. Paul H. J. Kouwer. Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels. Angewandte Chemie 2020, 132, 2742 -2746.
AMA StyleHongbo Yuan, Dr. Yong Zhan, Dr. Alan E. Rowan, Dr. Chengfen Xing, Dr. Paul H. J. Kouwer. Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels. Angewandte Chemie. 2020; 132 (7):2742-2746.
Chicago/Turabian StyleHongbo Yuan; Dr. Yong Zhan; Dr. Alan E. Rowan; Dr. Chengfen Xing; Dr. Paul H. J. Kouwer. 2020. "Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels." Angewandte Chemie 132, no. 7: 2742-2746.
Yanjing Wang; Hongbo Yuan; Dawei Li; Chengfen Xing. CO2/NIR light dual-controlled nanoparticles for dsDNA unzipping. Chinese Chemical Letters 2020, 31, 281 -284.
AMA StyleYanjing Wang, Hongbo Yuan, Dawei Li, Chengfen Xing. CO2/NIR light dual-controlled nanoparticles for dsDNA unzipping. Chinese Chemical Letters. 2020; 31 (1):281-284.
Chicago/Turabian StyleYanjing Wang; Hongbo Yuan; Dawei Li; Chengfen Xing. 2020. "CO2/NIR light dual-controlled nanoparticles for dsDNA unzipping." Chinese Chemical Letters 31, no. 1: 281-284.
CO2-responsive polymeric nano-objects with assembly-related aggregation-induced emission (AIE) are obtained via polymerization-induced self-assembly (PISA) of 2-(dimethylamino)ethyl methacrylate (DMAEMA), 2-(4-formylphenoxy)ethyl methacrylate (MAEBA) and 4-(1, 2, 2-triphenylvinyl) phenyl methacrylate (TPEMA). These nano-objects exhibit, depending on the feed of MAEBA, a morphology evolution process from spherical micelles to vesicles. Due to the presence of DMAEMA units, CO2 promotes morphology transformation of the nano-objects from spheres to a mixture of “jellyfish” and vesicles, and vesicles to complex vesicles. Moreover, TPEMA endows the AIE feature to these nano-objects, offering a strategy to monitor the morphology evolution process in real-time. Thus, this approach is significant for exploring the assembly mechanism of copolymer in polymerization-induced self-assembly and designing multi-stimuli responsive polymeric nano-materials with tunable morphologies and sizes.
Liang Qiu; Haoran Zhang; Bo Wang; Yong Zhan; Chengfen Xing; Cai-Yuan Pan. CO2-Responsive Nano-Objects with Assembly-Related Aggregation-Induced Emission and Tunable Morphologies. ACS Applied Materials & Interfaces 2019, 12, 1348 -1358.
AMA StyleLiang Qiu, Haoran Zhang, Bo Wang, Yong Zhan, Chengfen Xing, Cai-Yuan Pan. CO2-Responsive Nano-Objects with Assembly-Related Aggregation-Induced Emission and Tunable Morphologies. ACS Applied Materials & Interfaces. 2019; 12 (1):1348-1358.
Chicago/Turabian StyleLiang Qiu; Haoran Zhang; Bo Wang; Yong Zhan; Chengfen Xing; Cai-Yuan Pan. 2019. "CO2-Responsive Nano-Objects with Assembly-Related Aggregation-Induced Emission and Tunable Morphologies." ACS Applied Materials & Interfaces 12, no. 1: 1348-1358.
Cells are normally cultured in 2D environment which is usually inconsistent with the real microenvironment in vivo and it is rarely reported that effective cancer cells killing process occurs in 3D network environment. Herein, a kind of new biomimetic composite hydrogel which can achieve 3D cell culture has been prepared and constructed by assembly of polyisocyanopeptide (PIC) with cationic oligo (p-phenylene vinylene) (OPV). The polymer chains of PIC can be bound and frizzled to form 3D network when the temperature rises above the gelation temperature, followed by encapsulating the cells into biomimetic composite hydrogel. Cells grow and proliferate well in 3D composite hydrogels with excellent cell viability. When the cells undergo cancerization or microbial infection during the 3D culture, the addition of the luminol luminescence system can cause strong bioluminescence resonance energy transfer (BRET) process to produce highly active reactive oxygen species (ROS) in 3D culture and kill the cancer cells and pathogenic microorganism effectively. Utilizing the BRET process in 3D composite biomimetic hydrogels provides an efficient antibacterial and anticancer approach in 3D culture to overcome the light-penetration limitation.
JingQi Guo; Chengfen Xing; Hongbo Yuan; Ran Chai; Yong Zhan. Oligo (p-Phenylene Vinylene)/Polyisocyanopeptide Biomimetic Composite Hydrogel-Based Three-Dimensional Cell Culture System for Anticancer and Antibacterial Therapeutics. ACS Applied Bio Materials 2019, 2, 2520 -2527.
AMA StyleJingQi Guo, Chengfen Xing, Hongbo Yuan, Ran Chai, Yong Zhan. Oligo (p-Phenylene Vinylene)/Polyisocyanopeptide Biomimetic Composite Hydrogel-Based Three-Dimensional Cell Culture System for Anticancer and Antibacterial Therapeutics. ACS Applied Bio Materials. 2019; 2 (6):2520-2527.
Chicago/Turabian StyleJingQi Guo; Chengfen Xing; Hongbo Yuan; Ran Chai; Yong Zhan. 2019. "Oligo (p-Phenylene Vinylene)/Polyisocyanopeptide Biomimetic Composite Hydrogel-Based Three-Dimensional Cell Culture System for Anticancer and Antibacterial Therapeutics." ACS Applied Bio Materials 2, no. 6: 2520-2527.
CO2-controlled assembly of conjugated polymer and boron nitride (BN) was fabricated via electrostatic and hydrophobic interactions between the BN fiber and conjugated polymer of PFBT containing fluorene units and 2,1,3-benzothiadiazole units. CO2, an effective and green stimulus for regulating the assembly of PFBT and BN fibers, leads to an obvious fluorescence variation. Moreover, PFBT enables the assembly with the signal amplification and light-harvesting properties. This work provides a new triggering method to construct intelligent conjugated polymer-based platform, and offers fluorescence monitoring strategy for carbon dioxide capture.
Bo Wang; Chengfen Xing; Dong Gao; Hongbo Yuan; Liang Qiu; Xue Yang; Yang Huang; Yong Zhan. Carbon dioxide-controlled assembly based on conjugated polymer and boron nitride. Chinese Chemical Letters 2019, 31, 261 -264.
AMA StyleBo Wang, Chengfen Xing, Dong Gao, Hongbo Yuan, Liang Qiu, Xue Yang, Yang Huang, Yong Zhan. Carbon dioxide-controlled assembly based on conjugated polymer and boron nitride. Chinese Chemical Letters. 2019; 31 (1):261-264.
Chicago/Turabian StyleBo Wang; Chengfen Xing; Dong Gao; Hongbo Yuan; Liang Qiu; Xue Yang; Yang Huang; Yong Zhan. 2019. "Carbon dioxide-controlled assembly based on conjugated polymer and boron nitride." Chinese Chemical Letters 31, no. 1: 261-264.
Spatiotemporal regulation of cellular functions provides a powerful strategy for understanding underlying mechanisms of cellular bioprocesses. Here, a strategy is reported to realize the remote control of the activities of potassium channels via photothermal inactivation of calmodulin (CaM) by using reduced graphene oxide decorated with calmodulin binding peptide (rGO‐P) as the transducer with near‐infrared light (NIR) irradiation. Upon NIR light irradiation, the CaM/Ca2+ bound to rGO‐P is inactivated by the photothermal effect of rGO‐P, resulting in the incapability of binding with Ca2+. Hence, the closed Kv10.1 channel is converted to be open in the presence of calcium in living cells. Meanwhile, the SK2 channel is induced to be closed from the open state and the Kir2.1 channel is unaffected by the intracellular inactivation of CaM. This strategy gives a noninvasive and effective approach to remotely control the activities of potassium channels, offering an alternative for the development of optogenetics.
Ran Chai; Chengfen Xing; Ng Gao; Hongbo Yuan; Yong Zhan; Shu Wang. Remote‐Controlling Potassium Channels in Living Cells through Photothermal Inactivation of Calmodulin. Advanced Healthcare Materials 2018, 7, e1800674 .
AMA StyleRan Chai, Chengfen Xing, Ng Gao, Hongbo Yuan, Yong Zhan, Shu Wang. Remote‐Controlling Potassium Channels in Living Cells through Photothermal Inactivation of Calmodulin. Advanced Healthcare Materials. 2018; 7 (19):e1800674.
Chicago/Turabian StyleRan Chai; Chengfen Xing; Ng Gao; Hongbo Yuan; Yong Zhan; Shu Wang. 2018. "Remote‐Controlling Potassium Channels in Living Cells through Photothermal Inactivation of Calmodulin." Advanced Healthcare Materials 7, no. 19: e1800674.
The synthetic control over pore structure and multi-functionality remain highly desirable for conjugated microporous polymers (CMPs). Here, we demonstrate that the 1,10-phenanthroline-like S,N-heteroacenes are ideal building blocks to construct a new kind of CMPs by Sonogashira polymerization. The enlarged conjugation and rigidity of the repeating units played a vital role in the formation of permanent micropores with large specific surface areas. The versatility of these CMPs for applications as fluorescent sensors and highly efficient anti-microbial carriers were explored. These fluorescent and electron rich conjugated frameworks exhibit optical sensing performance toward nitroaromatic explosives with good selectivity and sensitivity. Moreover, for the first time, CMPs were used as heterogeneous anti-microbial carriers. The high micro-porosity, as well as the heterogeneous features of these CMPs, with specific interaction sites with silver, allow them efficient loading of silver nanoparticles with well controlled size for effective anti-microbial activity.
Mengjiao Wu; Yi Han; Bo Wang; Yuan Yuan; Chengfen Xing; Yulan Chen. S,N-Heteroacene-Based Conjugated Microporous Polymers as Fluorescent Sensors and Effective Antimicrobial Carriers. ACS Applied Bio Materials 2018, 1, 473 -479.
AMA StyleMengjiao Wu, Yi Han, Bo Wang, Yuan Yuan, Chengfen Xing, Yulan Chen. S,N-Heteroacene-Based Conjugated Microporous Polymers as Fluorescent Sensors and Effective Antimicrobial Carriers. ACS Applied Bio Materials. 2018; 1 (2):473-479.
Chicago/Turabian StyleMengjiao Wu; Yi Han; Bo Wang; Yuan Yuan; Chengfen Xing; Yulan Chen. 2018. "S,N-Heteroacene-Based Conjugated Microporous Polymers as Fluorescent Sensors and Effective Antimicrobial Carriers." ACS Applied Bio Materials 1, no. 2: 473-479.