Professor Paul J Thornalley (PhD Biochemistry, University of Oxford, UK). He is a leading researcher in studies of pathogenesis of hyperglycemia leading to the development of insulin resistance, beta-cell glucotoxicity, type 2 diabetes and vascular complication of diabetes. He is considered founding investigator of the reactive glucose-derived metabolite, methylglyoxal, and its metabolism by glyoxalase 1 (Glo1) of the glyoxalase system. He developed the “Hexokinase-linked glycolytic overload and unscheduled glycolysis” hypothesis of hyperglycemia-induced pathogenesis in insulin resistance, beta-cell glucotoxicity and diabetic vascular complications. He also originated the strategy for development of small molecule inducers of Glo1 expression or “Glo1 inducer” therapeutics for treatment of insulin resistance and microvascular complications of diabetes – proven effective in clinical trial. His h-index is 111 with ca 46,000 citations of his work.