Upon completion of his medical degree and urology residency at St Radboud University Hospital in Nijmegen, the Netherlands he worked there as a urologist from 1992–2002. He was appointed Professor and Chair at the Department of Urology at Amsterdam UMC, Amsterdam, the Netherlands from 2002 to 2018. He has held the position of Professor in Urology at Istanbul Medipol University in Istanbul, Turkiye since 2018 and the position of Professor in Urology at Bashkir State Medical University in Ufa, Russia, since 2025. His main fields of interest are minimally invasive urological surgery, endourology, ablative treatments, and urological imaging. He is the founding co-chairman of the EAU Section of Uro-Technology (ESUT) and the founding chairman of the European Association of Urology (EAU) BPH guidelines committee. He served as a board member of the Society of Endourology during 1996–2016. He is strongly committed to research and is the founding chair of the CROES (Clinical Research Office of the Endourology Society). From 2016 to 2022 he held the position of General Secretary of the Societe International d'Urologie and has been the President of the Societe International d'Urologie since 2024. Dr de la Rosette is (co)author of over 750 peer-reviewed publications, has authored many book chapters, and has an H-index of 113.