An efficient and metal free methodology for the synthesis of bis(indolyl)methanes (BIMs) and bis(aryl)alkanes derivatives in the presence of B(C₆F₅)₃ by the condensation of primary amines with pyruvates with good to high yields have been successfully developed. Some BIMs derivatives displayed good in vitro antitumor activity, screened by MTT assay. Compound 3b show the best anti-cancer activity against lung carcinoma cell A549 cells with IC50 of 4.52 µM.

An efficient metal free high yield method of synthesis of bis(indolyl)methanes (BIMs) and bis(aryl)alkanes analogs in the presence of B(C₆F₅)₃ by condensation of primary amines with pyruvates has been successfully developed. Some analogs of BIMs display good in vitro antitumor activity, screened by MTT assay. Compound 3b demonstrates the best anti-cancer activity against lung carcinoma cell A549 cells with IC₅₀ of 4.52 µM.