Central nervous system diseases (CNSDs) lead to significant disability worldwide. Mobile app interventions have recently shown the potential to facilitate monitoring and medical management of patients with CNSDs. In this direction, the characteristics of the mobile apps used in research studies and their level of clinical effectiveness need to be explored in order to advance the multidisciplinary research required in the field of mobile app interventions for CNSDs. A systematic review of mobile app interventions for three major CNSDs, i.e., Parkinson’s disease (PD), multiple sclerosis (MS), and stroke, which impose significant burden on people and health care systems around the globe, is presented. A literature search in the bibliographic databases of PubMed and Scopus was performed. Identified studies were assessed in terms of quality, and synthesized according to target disease, mobile app characteristics, study design and outcomes. Overall, 21 studies were included in the review. A total of 3 studies targeted PD (14%), 4 studies targeted MS (19%), and 14 studies targeted stroke (67%). Most studies presented a weak-to-moderate methodological quality. Study samples were small, with 15 studies (71%) including less than 50 participants, and only 4 studies (19%) reporting a study duration of 6 months or more. The majority of the mobile apps focused on exercise and physical rehabilitation. In total, 16 studies (76%) reported positive outcomes related to physical activity and motor function, cognition, quality of life, and education, whereas 5 studies (24%) clearly reported no difference compared to usual care. Mobile app interventions are promising to improve outcomes concerning patient’s physical activity, motor ability, cognition, quality of life and education for patients with PD, MS, and Stroke. However, rigorous studies are required to demonstrate robust evidence of their clinical effectiveness.

The enforcement of fine-grained access control policies in constrained dynamic networks can become a challenging task. The inherit constraints present in those networks, which result from the limitations of the edge devices in terms of power, computational capacity and storage, require an effective and efficient access control mechanism to be in place to provide suitable monitoring and control of actions and regulate the access over the resources. In this article, we present RESPOnSE, a framework for the specification and enforcement of security policies within such environments, where the computational burden is transferred to high-tier nodes, while low-tier nodes apply risk-aware policy enforcement. RESPOnSE builds on a combination of two widely used access control models, Attribute-Based Access Control and Role-Based Access Control, exploiting the benefits each one provides. Moreover, the proposed mechanism is founded on a compensatory multicriteria decision-making algorithm, based on the calculation of the Euclidean distance between the run-time values of the attributes present in the security policy and their ideal values, as those are specified within the established policy rules.