Alberto Izzotti has managed several research projects devoted to (a) developing drugs for cancer prevention; (b) developing, in preclinical models, molecular tools applicable in a clinic; (c) shedding light on cancer ethio-pathogenesis; and (d) evaluating intermediate molecular biomarkers in clinical trials. In the last 10 years, he has mainly been involved in personalized medicine and postgenomic analyses using a microarray for the evaluation of the expression of genes and proteins. Since 2008, his research activity has been devoted to the study of microRNA, cancer chemo-preventive agents, and gene transfer methods. He has also managed several grants for national and international projects.