Agricultural activities are essential for sustaining the global population, yet they exert considerable pressure on the environment. A major challenge we face today is agricultural pollution, much of which is diffuse in nature, lacking a clear point of origin for chemical discharge. Modern agricultural practices, which often depend on substantial applications of fertilizers, pesticides, and irrigation water, are key contributors to this form of pollution. These activities lead to downstream contamination through mechanisms such as surface runoff, leaching, soil erosion, wind dispersal, and sedimentation. The environmental and human health consequences of diffuse pollution are profound and cannot be ignored. Accurate assessment of the risks posed by agricultural pollutants is crucial for ensuring the production of safe, high-quality food while safeguarding the environment. This requires systematic monitoring and evaluation of agricultural practices, including soil testing and nutrient management. Furthermore, the development and implementation of best management practices (BMPs) are critical in reducing the levels of agricultural pollution. Such measures are essential for mitigating the negative impacts on ecosystems and public health. Therefore, the adoption of preventive strategies aimed at minimizing pollution and its associated risks is highly recommended to ensure long-term environmental sustainability and human well-being.

Purpose of Review: The synergistic effects of microplastics (MPs) and heavy metals are becoming major threats to aquatic life and human well-being. Therefore, understanding synergistic interactions between MPs and heavy metals is crucial to comprehend their environmental impacts. Recent Findings: The mechanisms such as electrostatic attraction, surface interactions, ion exchange, hydrogen bonding, hydrophobic forces, and π–π interactions behind the synergistic effects of MPs and heavy metals were critically reviewed and justified. In addition, the roles of surface chemistry in these interactions were also emphasized. Finally, efficient remediation techniques aligning with a circular economy-based initiative to promote sustainable solutions were recommended to mitigate plastic-heavy metal pollution to achieve a cleaner environment. Summary: This review examines the combined impact of MPs and heavy metals in aquatic ecosystems, detailing their mechanistic interactions, and consequences with proposed sustainable solutions. Additionally, this review highlights the MP-heavy metal contamination risks and emphasizes the need for further research to safeguard aquatic life and human health.