José Manuel García-Aznar

Prof. José Manuel García-Aznar

Multiscale in Mechanical and Biological Engineering (M2BE), Mechanical Engineering Department, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Maria de Luna 7, Campus Rio Ebro, Edificio "Agustín de Betancourt" 50018 Zaragoza, Spain
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Research Focus & Metrics

Academic Career Length

26Years (2001-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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9 September 2016 in Science
Verified
Journal Article
Open access
PDF file
RSRaimon Sunyer
Raimon Sunyer
VCVito Conte
Vito Conte
JEJorge Escribano
Jorge Escribano
AEAlberto Elosegui-Artola
Alberto Elosegui-Artola
ALAnna Labernadie
Anna Labernadie
XTXavier Trepat
Xavier Trepat
The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cells did not. This emergent mode of directed collective cell migration applied to a variety of epithelial cell types, required the action of myosin motors, and originated from supracellular transmission of contractile physical forces. To explain the observed phenomenology, we developed a generalized clutch model in which local stick-slip dynamics of cell-matrix adhesions was integrated to the tissue level through cell-cell junctions. Collective durotaxis is far more efficient than single-cell durotaxis; it thus emerges as a robust mechanism to direct cell migration during development, wound healing, and collective cancer cell invasion.

1 September 2004 in Engineering Fracture Mechanics
Verified
Journal Article
Closed access
MDM. Doblaré
M. Doblaré
José Manuel García-AznarJosé Manuel García-Aznar
José Manuel García-Aznar
MGM.J. Gómez
M.J. Gómez

1 January 2002 in Journal of Biomechanics
Verified
Journal Article
Closed access
MDM. Doblaré
M. Doblaré
José Manuel García-AznarJosé Manuel García-Aznar
José Manuel García-Aznar

1 January 2009 in Acta Biomaterialia
Verified
Journal Article
Closed access
Jose Sanz-HerreraJose Sanz-Herrera
Jose Sanz-Herrera
José Manuel García-AznarJosé Manuel García-Aznar
José Manuel García-Aznar
MDM Doblare
M Doblare

1 July 2005 in Journal of Theoretical Biology
Verified
Journal Article
Closed access
MGM.J. Gómez-Benito
M.J. Gómez-Benito
José Manuel García-AznarJosé Manuel García-Aznar
José Manuel García-Aznar
JKJ.H. Kuiper
J.H. Kuiper
MDM. Doblaré
M. Doblaré

8 June 2005 in Biomechanics and Modeling in Mechanobiology
Verified
Journal Article
Closed access
PDF file
José Manuel García-AznarJosé Manuel García-Aznar
José Manuel García-Aznar
TRT. Rueberg
T. Rueberg
Manuel DoblaréManuel Doblaré
Manuel Doblaré